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ANGPTL3 encodes a member of a family of secreted proteins that function in angiogenesis. Additionally we are shipping ANGPTL3 Antibodies (162) and ANGPTL3 Kits (55) and many more products for this protein.
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Human ANGPTL3 Protein expressed in HEK-293 Cells - ABIN2180588
Conklin, Gilbertson, Taft, Maurer, Whitmore, Smith, Walker, Chen, Wattler, Nehls, Lewis: Identification of a mammalian angiopoietin-related protein expressed specifically in liver. in Genomics 2000
Human ANGPTL3 Protein expressed in Human - ABIN1344368
Broxmeyer, Srour, Cooper, Wallace, Hangoc, Youn: Angiopoietin-like-2 and -3 act through their coiled-coil domains to enhance survival and replating capacity of human cord blood hematopoietic progenitors. in Blood cells, molecules & diseases 2012
Knockdown of Angptl3 decreases liver size in developing zebrafish.
The ANGPTL3 gene lies within DOCK7, although the variant is within non-coding regions outside of ANGPTL3, within DOCK7, suggesting complex long-range regulatory effects on gene expression in coronary artery disease.
ANGPTL3 levels were associated with fasting insulin (show INS Proteins) and the homeostasis model assessment of insulin (show INS Proteins) resistance in Korean children.
An ANGPTL3-4-8 model was proposed to explain the variations of lipoprotein lipase (LPL (show LPL Proteins)) activity during the fed-fast cycle. Feeding induces ANGPTL8, activating the ANGPTL8-ANGPTL3 pathway, which inhibits LPL (show LCP1 Proteins) in cardiac and skeletal muscles to direct circulating triglycerides (TG) to white adipose tissue; the reverse is true during fasting, which suppresses ANGPTL8 but induces ANGPTL4 (show ANGPTL4 Proteins), thereby directing TG to muscles.
Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion
Novel mutation Y344S found in ANGPTL3 gene in two diabetic patients with familial hypobetalipoproteinemia.
Data suggest that silencing of ANGPTL 3 (angiopoietin-like protein 3) improves insulin (show INS Proteins) sensitivity.
HCV core represses ANGPTL-3 expression through loss of HNF-1alpha binding activity and blockage of LXR/RXR transactivation
Data suggest that genetic polymorphisms in ANGPTL3 (angiopoietin-like 3 protein), TIMD4 (show TIMD4 Proteins) (T cell immunoglobulin mucin-4 (show MUC4 Proteins)), and apolipoproteins A5 and B are among the genetic determinants of hypertriglyceridemia in Amerindian populations. [REVIEW]
ANGPTL3 is positively associated with low-density lipoprotein cholesterol and high-density lipoprotein cholesterol and not with metabolic syndrome traits including triglycerides.
Identification of loss-of-function ANGPTL3 mutation is shedding light on a possible role of ANGPTL3 at the crossroads of lipoproteins, fatty acids, and glucose metabolism. [Review]
This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 and Angptl4 (show ANGPTL4 Proteins) at different nutritional statuses.
The deletion of ANGPTL3 tremendously attenuates proteinuria and protects podocytes from injury in a mouse model of adriamycin-induced nephropathy.
ANGPTL3 has a role in regulating white adipose tissue energy homeostasis but not in liver
Data indicate that expression of Angptl3 in hematopoietic stem cell (HSC (show FUT1 Proteins)) through lentiviral transduction promoted HSC (show FUT1 Proteins) expansion.
Angptl3 could induce actin filament rearrangement, mainly in lamellipodia formation, and that this process was mediated by integrin alpha(V)beta-mediated FAK and PI3K phosphorylation and Rac1 activation.
Furin (show FURIN Proteins) has a role as the primary in vivo convertase of ANGPTL3 and endothelial lipase (show LIPG Proteins) in hepatocytes
ANGPTL8, a paralog of ANGPTL3 that arose through duplication of an ancestral DOCK gene, regulates postprandial TAG and fatty acid metabolism by controlling activation of its progenitor, and perhaps other ANGPTLs
Angptl3, as an extrinsic factor, thus supports the stemness of hematopoietic stem cells in the bone marrow niche.
ANGPTL3 expression is upregulated in puromycin-induced podocyte damage and is associated with the reduction of perlecan (show HSPG2 Proteins) and agrin (show AGRN Proteins) expression
First report of molecular cloning and characterization of ANGPTL3 in pigs, which will be helpful for a better understanding of the role of ANGPTLs in lipid metabolism.
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2.
, WITHDRAWN: zgc:111943
, angiopoietin-related protein 3-like
, angiopoietin 5
, angiopoietin-related protein 3
, angiopoietin-like protein 3