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Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Additionally we are shipping ANGPTL2 Antibodies (71) and ANGPTL2 Kits (47) and many more products for this protein.
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Results reveal a novel cascade comprising sequential P. gingivalis lipopolysaccharide --> ANGPTL2 --> integrin alpha5beta1 --> inflammatory cytokine induction, which might be responsible for inducing potent periodontal disorganization activity in gingival epithelial cells. Via this pathway, ANGPTL2 functions in the pathogenesis of periodontitis and contributes to prolonging chronic inflammation in patients with systemi...
In patients with type 2 diabetes, serum ANGPTL2 concentrations were independently associated with death and MACE.
Elevated serum ANGPTL2 levels are a novel risk factor for the development of CVD in the general population. This association is partially mediated by metabolic disorders and inflammation.
Increased ANGPTL2 expression contributes to proliferation and invasion of gastric cancer cells.
Aberrant expression of ANGPTL2 in cumulus cells is potentially associated with impaired oocyte developmental competence in polycystic ovary syndrome.
Reduced leukocyte DNA methylation (show HELLS Proteins) in the promoter region of ANGPTL2 is associated with the pro-inflammatory environment that characterizes patients with post-ACS (show PLA2G15 Proteins) differently from age-matched healthy controls. Methylation of different CpGs in ANGPTL2 gene may prove to be a reliable biomarker of coronary disease
At 11-13 weeks in pregnancies that develop GDM, the serum concentration of ANGPTL2 is increased, and it can be combined with maternal factors to provide effective early screening for GDM.
ANGPTL2 and TGF-beta1 (show TGFB1 Proteins) positively regulate each other as renal fibrosis progresses.
signaling involving ANGPTL2 and LILRB2 (show LILRB2 Proteins) is important for lung cancer development
ANGPTL2 may be a useful marker for detecting early postoperative recurrence in patients with gastric cancer.
These results support the importance of ANGPTL2 in the stem cell niche in regulating stemness and epithelial wound healing in the intestine.
we provide the first evidence for ANGPTL2 function in the acute ischemic brain. Infiltrated macrophage-derived ANGPTL2 enhanced inflammatory responses and was associated with severe brain tissue damage in the acute phase of ischemic stroke.
Angptl2 deficiency in lung epithelial cells and resident alveolar macrophages causes severe lung fibrosis seen following bleomycin treatment, suggesting that ANGPTL2 derived from these cell types plays a protective role against fibrosis in lung.
Angptl2 regulates not only adipose tissue metabolism but also bone metabolism
findings suggest that macrophage-derived ANGPTL2 promotes an innate immune response in those cells by enhancing proinflammatory activity and NO production required to fight infection.
Angptl2 might therefore represent a multistep regulator of CNV pathogenesis and serve as a new therapeutic target for age-related macular degeneration.
ANGPTL2 promotes adipose tissue macrophage and T lymphocyte accumulation and leads to insulin (show INS Proteins) resistance.
Angptl2 induces proinflammatory responses in peritoneal macrophages and monocytes.
In angptl2 knockdown mice, ACh (show FGFR3 Proteins)-mediated endothelium-dependent vasodilation was greater than in WT mice. Lack of angptl2 expression limits the metabolic stress induced by a high-fat diet and maintains endothelial function in mice.
knockdown of angptl2 may be protective against ANG II (show AGT Proteins)-induced cerebral endothelial dysfunction; it favors the production of NO increasing endothelial cell resistance to stress.
Data show that angiopoietin-like proteins zangptl1 and 2 are required for definitive HSPCs formation, and genetically interact with notch (show NOTCH1 Proteins) receptor.
developmental expression of Angptl1 (show ANGPTL1 Proteins), 2 and 6 in zebrafish
Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action.
angiopoietin-like protein 2
, angiopoietin-related protein 2
, angiopoietin related protein 2
, angiopoietin-like 2
, angiopoietin-related protein-2
, fibrinogen-like protein
, angiopoietin-like 2 a
, angiopoietin-related protein 2-like