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The protein encoded by ACE2 belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme.
ollectrin, an ACE2 homolog with no catalytic activity, regulates blood pressure through an NO-dependent mechanism. Large body of experimental data confirmed sustained beneficial effects of ACE2/Ang-(1 (show ANGPT1 Antibodies)-7)/Mas (show MAS1 Antibodies) receptor axis activation on hypertension and vascular injury.
The potential contribution of the ACE2 to cardiovascular disease progression was addressed.
Serum ACE2 activity was significantly lower in acute ischemic stroke as compared to both control and stroke-alert patients, followed by an increase to control levels at three days.
Here, we review the role and effects of ACE2, ACE2 activators, Ang-(1 (show ANGPT1 Antibodies)-7) and synthetic Mas (show MAS1 Antibodies) receptor agonists in the control of inflammation and fibrosis in cardiovascular and renal diseases and as counter-regulators of the ACE (show ACE Antibodies)-Ang II (show AGT Antibodies)-AT1 (show AGTR1 Antibodies) axis.
ACE2 overexpression inhibited cell growth.
Downregulation of ACE2/Ang-(1 (show ANGPT1 Antibodies)-7)/Mas (show MAS1 Antibodies) axis stimulates breast cancer metastasis through the activation of store-operated calcium entry and PAK1 (show PAK1 Antibodies)/NF-kappaB (show NFKB1 Antibodies)/Snail1 (show SNAI1 Antibodies) pathways.
The circulating ACE2 and Ang-(1 (show ANGPT1 Antibodies)-7) levels were related to neither rs4646155 nor rs879922 in female or male patients.In conclusion, the rs2106809 polymorphism of the ACE2 gene may be a determinant of the circulating Ang-(1 (show ANGPT1 Antibodies)-7) level in female patients with hypertension, suggesting a genetic association between circulating Ang-(1 (show ANGPT1 Antibodies)-7) levels and ACE2 gene polymorphisms in patients with hypertension.
These results indicated that angiotensin-(1-7)/ACE2/Mas (show MAS1 Antibodies) axis may reduce liver lipid accumulation partly by regulating lipid-metabolizing genes through ATP/P2 receptor/CaM (show CALM1 Antibodies) signaling pathway.
ACE-2 significantly increased when IMR-90 were hypoxic prior to hyperoxic exposure with no recovery.
Imbalanced down-regulation of ACE (show ACE Antibodies) and ACE2 mRNA expression levels may play an important role in the development and progression of thoracic aortic aneurysmal dilatation and subsequently dissection.
These findings demonstrate that ACE2 plays a critical role in preventing RSV-induced lung injury, and suggest that ACE2 is a promising potential therapeutic target in the management of RSV-induced lung disease.
ACE2 overexpression significantly reduced the myocardial infarction-induced increase in apoptosis, macrophage infiltration, and HMGB1 (show HMGB1 Antibodies) and proinflammatory cytokine expression.
ACE2 regulates vascular function by modulating nitric oxide release.
MAS (show MAS1 Antibodies) receptors mediate vasoprotective and atheroprotective effects of candesartan upon the recovery of vascular ACE2-angiotensin-(1-7)-MAS (show MAS1 Antibodies) axis functionality
ACE2 plays a novel role in heart disease associated with obesity wherein ACE2 negatively regulates obesity-induced epicardial adipose tissue inflammation and cardiac insulin (show INS Antibodies) resistance.
a Mas (show MAS1 Antibodies) receptor-mediated mechanism may stimulate pancreatic cell development
ACE2 deficiency exacerbates kidney inflammation, oxidative stress and adverse renal injury in the ApoE (show APOE Antibodies)-mutant mice through modulation of the nephrin (show NPHS1 Antibodies), NOX4 (show NOX4 Antibodies) and TNF-alpha (show TNF Antibodies)-TNFRSF1A (show TNFRSF1A Antibodies) signaling.
Hydronephrosis led to an increase of ACE (show ACE Antibodies) level and a decrease of ACE2 and Mas (show MAS1 Antibodies) receptor in the heart.
Overexpression of ADAM17 (show ADAM17 Antibodies) increases shed ACE2 and decreases cellular ACE2 levels in pancreatic islets. Whereas ADAM17 (show ADAM17 Antibodies) has the ability to shed ACE2, ADAM17 (show ADAM17 Antibodies) does not deplete ACE2 from pancreatic islets in diabetic db/db (show LEPR Antibodies) mice.
ACE2 and Ang-(1 (show ANGPT1 Antibodies)-7) significantly inhibit early atherosclerotic lesion formation via protection of endothelial function and inhibition of inflammatory response.
The objective of this study was to characterize the profiles of Ang-(1-7), MAS receptor, ACE(2), NEP and PEP during the ovulatory process in cattle.
sporadic non-synonymous substitutions reduced the level of rh-ACE2 protein expression and did not support severe acute respiratory syndrome coronavirus entry effectively
In a pig model of acute pulmonary embolism leading to cardiac arrest, captopril infusion was associated with less mean right ventricular pressure overload after resuscitation, compared with saline infusion. The reduction in systemic and pulmonary vascular resistance associated with captopril may be by inhibiting the ACE (show ACE Antibodies)-Ang II (show AGT Antibodies)-AT1R (show AGTR1 Antibodies) axis and activating the ACE2/Ang-(1 (show ANGPT1 Antibodies)-7)/Mas (show MAS1 Antibodies) axis.
This study produced the full-length porcine ACE2 cDNA sequence and found polyunsaturated fatty acids could downregulate the expression of ACE2.
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
, angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
, angiotensin-converting enzyme 2
, angiotensin-converting enzyme homolog
, metalloprotease MPROT15
, peptidyl-dipeptidase A
, angiotensin I converting enzyme 2
, anigotensin-converting enzyme-related carboxypeptidase
, renal angiotensin-converting enzyme 2