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AGTRAP encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. Additionally we are shipping Angiotensin II Receptor-Associated Protein Proteins (4) and Angiotensin II Receptor-Associated Protein Kits (3) and many more products for this protein.
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A role for AT1 receptor-associated proteins in blood pressure regulation
ATRAP, a directly interacting and functionally inhibiting molecule of AT1R (show AGTR1 Antibodies), plays a protective role against the development of systemic insulin (show INS Antibodies) resistance via regulatory effects on adipose tissue function.
The phosphatidylinositol transfer protein (show PITPNA Antibodies) RdgBbeta (show PITPNC1 Antibodies) binds 14-3-3 (show YWHAQ Antibodies) via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock.
CSF (show CSF2 Antibodies) angiotensin II, ACE (show ACE Antibodies), and ACE2 (show ACE2 Antibodies) levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 (show AQP4 Antibodies) antibody, reflecting severe destruction of perivascular astrocytes
Small interfering RNA significantly attenuates angiotensin II type 1 receptor (show AGTR1 Antibodies)-stimulated inositol phosphate formation.
cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein
isolation of a novel protein, ARAP1 (show ARAP1 Antibodies), which promotes recycling of angiotensin(1A) to the plasma membrane in HEK (show EPHA3 Antibodies)-293 cells
CAML (show CAMLG Antibodies) is an important signal transducer for the actions of Ang II (show AGT Antibodies) in regulating the calcineurin-NFAT (show NFATC1 Antibodies) pathway and the interaction of CAML (show CAMLG Antibodies) with ATRAP may mediate the Ang II (show AGT Antibodies) actions in vascular physiology
Renal ATRAP downregulation is involved in the onset and progression of blood pressure elevation caused by renal mass reduction, and implicates ATRAP as a therapeutic target for hypertension in chronic kidney disease.
These results implied that AngII could effectively induce EpiCs to differentiate into vascular smooth muscle-like cells through the AT1 receptor.
ATRAP expression in brown adipose tissue does not influence the pathogenesis of dietary obesity or metabolic disorders.
Identify Atrap as a novel regulatory protein (show TGFB1 Antibodies) of the cardiac Ca(2+)-ATPase SERCA2a (show CA-P60A Antibodies). Suggest that Atrap enhances the activity of SERCA2a (show ATP2A2 Antibodies) and, consequently, facilitates ventricular relaxation.
These results suggest that increased formation of AT1R-P2Y6R (show P2RY6 Antibodies) heterodimers with age may increase the likelihood of hypertension induced by Ang II (show AGT Antibodies).
although erythropoiesis and blood pressure are negatively controlled through the AT1 receptor inhibition in vivo, the pathways involved are complex and distinct
Distal tubule-dominant enhancement of ATRAP inhibits pathological renal sodium reabsorption and blood pressure elevation in response to high salt loading.
AT1R knockout mice were less vulnerable to controlled cortical impact-induced injury.
The inhibition of degradation of angiotensin II type 1 receptor (show AGTR1 Antibodies)-associated protein (show BCAP31 Antibodies) (ATRAP) and inactivation of AT1R-mediated p38 MAPK (show MAPK14 Antibodies) and STAT3 (show STAT3 Antibodies) signaling pathways, are involved cardiac hypertrophy.
Activation of aortic vascular ATRAP partially inhibits the Nox4 (show NOX4 Antibodies)/p22(phox (show CYBA Antibodies))-ROS (show ROS1 Antibodies)-p38MAPK (show MAPK14 Antibodies)/JNK (show MAPK8 Antibodies) pathway and pathological aortic hypertrophy provoked by Ang II (show AGT Antibodies)-mediated hypertension.
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
angiotensin II receptor-associated protein
, type-1 angiotensin II receptor-associated protein
, Type-1 angiotensin II receptor-associated protein
, AT1 receptor-associated protein
, ATI receptor-associated protein
, angiotensin II, type I receptor-associated protein
, AT1 receptor
, angiotensin II receptor, type I