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AGTRAP encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. Additionally we are shipping Angiotensin II Receptor-Associated Protein Antibodies (49) and Angiotensin II Receptor-Associated Protein Proteins (4) and many more products for this protein.
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A role for AT1 receptor-associated proteins in blood pressure regulation
ATRAP, a directly interacting and functionally inhibiting molecule of AT1R (show AGTR1 ELISA Kits), plays a protective role against the development of systemic insulin (show INS ELISA Kits) resistance via regulatory effects on adipose tissue function.
The phosphatidylinositol transfer protein (show PITPNA ELISA Kits) RdgBbeta (show PITPNC1 ELISA Kits) binds 14-3-3 (show YWHAQ ELISA Kits) via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein).
the GG genotype of the AGTRAP rs11121816 T/G single nucleotide polymorphism was associated with increased mortality in two cohorts of patients who had septic shock.
CSF (show CSF2 ELISA Kits) angiotensin II, ACE (show ACE ELISA Kits), and ACE2 (show ACE2 ELISA Kits) levels are decreased in neuromyelitis optica/NMO spectrum disorder patients with anti-AQP4 (show AQP4 ELISA Kits) antibody, reflecting severe destruction of perivascular astrocytes
Small interfering RNA significantly attenuates angiotensin II type 1 receptor (show AGTR1 ELISA Kits)-stimulated inositol phosphate formation.
cloned a new human gene cDNA that codes for a homolog of the murine Agtrap protein
isolation of a novel protein, ARAP1 (show ARAP1 ELISA Kits), which promotes recycling of angiotensin(1A) to the plasma membrane in HEK (show EPHA3 ELISA Kits)-293 cells
CAML (show CAMLG ELISA Kits) is an important signal transducer for the actions of Ang II (show AGT ELISA Kits) in regulating the calcineurin-NFAT (show NFATC1 ELISA Kits) pathway and the interaction of CAML (show CAMLG ELISA Kits) with ATRAP may mediate the Ang II (show AGT ELISA Kits) actions in vascular physiology
Renal ATRAP downregulation is involved in the onset and progression of blood pressure elevation caused by renal mass reduction, and implicates ATRAP as a therapeutic target for hypertension in chronic kidney disease.
These results implied that AngII could effectively induce EpiCs to differentiate into vascular smooth muscle-like cells through the AT1 receptor.
ATRAP expression in brown adipose tissue does not influence the pathogenesis of dietary obesity or metabolic disorders.
Identify Atrap as a novel regulatory protein (show TGFB1 ELISA Kits) of the cardiac Ca(2+)-ATPase SERCA2a (show CA-P60A ELISA Kits). Suggest that Atrap enhances the activity of SERCA2a (show ATP2A2 ELISA Kits) and, consequently, facilitates ventricular relaxation.
These results suggest that increased formation of AT1R-P2Y6R (show P2RY6 ELISA Kits) heterodimers with age may increase the likelihood of hypertension induced by Ang II (show AGT ELISA Kits).
although erythropoiesis and blood pressure are negatively controlled through the AT1 receptor inhibition in vivo, the pathways involved are complex and distinct
Distal tubule-dominant enhancement of ATRAP inhibits pathological renal sodium reabsorption and blood pressure elevation in response to high salt loading.
AT1R knockout mice were less vulnerable to controlled cortical impact-induced injury.
The inhibition of degradation of angiotensin II type 1 receptor (show AGTR1 ELISA Kits)-associated protein (show BCAP31 ELISA Kits) (ATRAP) and inactivation of AT1R-mediated p38 MAPK (show MAPK14 ELISA Kits) and STAT3 (show STAT3 ELISA Kits) signaling pathways, are involved cardiac hypertrophy.
Activation of aortic vascular ATRAP partially inhibits the Nox4 (show NOX4 ELISA Kits)/p22(phox (show CYBA ELISA Kits))-ROS (show ROS1 ELISA Kits)-p38MAPK (show MAPK14 ELISA Kits)/JNK (show MAPK8 ELISA Kits) pathway and pathological aortic hypertrophy provoked by Ang II (show AGT ELISA Kits)-mediated hypertension.
This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms.
angiotensin II receptor-associated protein
, type-1 angiotensin II receptor-associated protein
, Type-1 angiotensin II receptor-associated protein
, AT1 receptor-associated protein
, ATI receptor-associated protein
, angiotensin II, type I receptor-associated protein
, AT1 receptor
, angiotensin II receptor, type I