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ANK2 encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Additionally we are shipping ANK2 Kits (21) and and many more products for this protein.
Showing 10 out of 98 products:
Human Monoclonal ANK2 Primary Antibody for FM, ELISA - ABIN967633
Scotland, Zhou, Benveniste, Bennett: Nervous system defects of AnkyrinB (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB in premyelinated axons. in The Journal of cell biology 1999
Show all 5 references for ABIN967633
Human Monoclonal ANK2 Primary Antibody for ICC, IF - ABIN2485095
Bennett, Baines: Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. in Physiological reviews 2001
The identification and characterization of two functionally distinct ankyrin-B isoforms in heart provide compelling evidence that alternative splicing of the ANK2 gene regulates the fidelity of ankyrin-B interactions with proteins
Taken together, these observations reveal that AnkB (show ANKH Antibodies) is required for Prx (show PRX Antibodies) membrane anchoring and for maintenance of lens fiber cell hexagonal geometry, membrane skeleton organization, and biomechanics.
that ankyrin-B deficiency results in a metabolic syndrome that combines primary pancreatic beta cell insufficiency with peripheral insulin (show INS Antibodies) resistance
Functional relationships between PIK3C3 (show PIK3C3 Antibodies), dynactin (show DCTN1 Antibodies), and AnkB (show ANKH Antibodies) promote axonal transport of organelles and are required for normal axon length.
These findings identify an interaction between ankyrin-B and both Cav2.1 (show CACNA1A Antibodies) and Cav2.2 (show CACNA1B Antibodies) at the amino acid level that is necessary for proper Cav2.1 (show CACNA1A Antibodies) and Cav2.2 (show CACNA1B Antibodies) targeting in vivo.
Ankyrin-B protein (show LEPREL2 Antibodies) in heart failure: identification of a new component of metazoan cardioprotection.
AnkB (show ANKH Antibodies) reduction alters cardiac Na and Ca transport and enhances the coupled RyR (show RYR1 Antibodies) openings, resulting in more frequent Ca sparks and waves although the total SR Ca leak is unaffected.
Ankyrin-B then interacts with dynactin-4 (show DCTN5 Antibodies) and dystrophin (show DMD Antibodies), whereas dynactin-4 (show DCTN5 Antibodies) collaborates with dystrophin (show DMD Antibodies) in coordinating costamere-aligned microtubules
Ankyrin-B regulates Kir6.2 (show KCNJ11 Antibodies) membrane expression and function in heart.
Findings highlight the importance of the functional anatomy of the entire atrial distributed pacemaker complex and clearly demonstrate the role of AnkB (show ANKH Antibodies) in cardiac automaticity.
VariousANK2mutations are associated with a wide range of phenotypes, including aLQTS, especially with ventricular fibrillation, representing "ankyrin-B" syndrome.
Rare Variants in ANK2 Associated With Various Inherited Arrhythmia Syndromes.
the structures of ANK (show ANK1 Antibodies) repeats in complex with an inhibitory segment from the C-terminal regulatory domain and with a sodium channel Nav1.2 (show SCN2A Antibodies) peptide, are reported.
Gankyrin (show PSMD10 Antibodies) plays an essential role in estrogen-driven and GPR30 (show GPER Antibodies)-mediated endometrial carcinoma cell proliferation via the PTEN (show PTEN Antibodies)/PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling pathway.
ankyrin-B linker suppresses activity of the ANK (show ANK1 Antibodies) repeat domain through an intramolecular interaction, likely with a groove on the surface of the ANK (show ANK1 Antibodies) repeat solenoid, thereby regulating the affinities between ankyrin-B and its binding partners
Residues 63-73 of cdB3 is also essential for ankyrin binding.
Reduced ankyrin-B expression or mutations in ankyrin 2 are associated with atrial fibrillation.
Data show that DAnk2-binding is critical for beta spectrin function in vivo.
This gene encodes a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats\; a central region with a highly conserved spectrin binding domain\; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. The protein encoded by this gene is required for targeting and stability of Na/Ca exchanger 1 in cardiomyocytes. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome. Multiple transcript variants encoding different isoforms have been described.
ankyrin 2, neuronal
, ankyrin repeat and zinc finger domain containing protein 1
, brain ankyrin
, ankyrin B
, ankyrin, brain
, ankyrin-2, nonerythrocytic
, non-erythroid ankyrin
, ankyrin 2, brain
, ankyrin 3, epithelial