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Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains.
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Human Monoclonal Ankyrin G Primary Antibody for WB - ABIN2482474
Bennett, Baines: Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. in Physiological reviews 2001
Interaction of Ankyrin-G with EB1 (show MAPRE1 Antibodies) protein drives axon initial segment formation and neuronal polarity.
Ank3 is subject to complex alternative splicing regulation resulting in a diverse population of ankyrin-G isoforms in heart.
This study found that ankyrin-G regulates canonical Wnt (show WNT2 Antibodies) signaling by altering the subcellular localization and availability of beta-catenin (show CTNNB1 Antibodies) in proliferating cells.
The data support a model where ankyrinG-binding is required for preferential Nav1.6 (show SCN8A Antibodies) insertion into the axon initial segment plasma membrane during development.
CK2 (show CSNK2A1 Antibodies)-regulated IQJC-SCHIP-1 association with AnkG contributes to axon initial segment maintenance.
the structures of ANK (show ANKH Antibodies) repeats in complex with an inhibitory segment from the C-terminal regulatory domain and with a sodium channel Nav1.2 (show SCN2A Antibodies) peptide, are reported.
The giant exon of AnkG is required for assembly of the AIS (show AR Antibodies) and nodes of Ranvier and was a transformative innovation in evolution of the vertebrate nervous system that now is a potential target in neurodevelopmental disorders.
giant ankyrin-G promotes GABAergic synapse stability through opposing endocytosis of GABAA (show GABRg1 Antibodies) receptors, and requires a newly described interaction with GABARAP (show GABARAP Antibodies), a GABAA receptor-associated protein (show GABARAP Antibodies).
In embryonic mouse axons, AnkG is expressed at the beginning of axonogenesis at E9.5 and initially distributed homogeneously along the entire growing axon. From E11.5 the protein progressively becomes restricted to the proximal axon.
Ankyrin-G targets Nav1.5 (show SCN5A Antibodies) to the intercalated disc. Ank3 KO mice display conduction defects and arrhythmias.
Whole-exome sequencing in ASD (show ARSD Antibodies) patients from each family identified a second rare inherited genetic variant, affecting either the ANK3 genes encoding NLGN4X (show NLGN4X Antibodies) interacting proteins expressed in inhibitory or in excitatory synapses.
we investigated the association of CACNA1C (show CACNA1C Antibodies) and ANK3 with SZ using meta-analytic techniques.
ankyrin-G associates with and inhibits the endocytosis of VE-cadherin (show CDH5 Antibodies) cis (show CISH Antibodies) dimers.
ANK3 rs10761482 showed a significant association with bipolar disorder
ANK3 bipolar-risk polymorphisms are associated with hyperactivation in the ventral anterior cingulate cortex in bipolar disorder.
Phosphorylation of KCNQ2 (show KCNQ2 Antibodies) and KCNQ3 (show KCNQ3 Antibodies) anchor domains by protein kinase CK2 (show CSNK2A1 Antibodies) augments binding to AnkG.
Data suggest that death domain of ankyrin G (ANK3-DD; located near C-terminus) exhibits C-terminal tail that curves back so that aromatic ring of a phenylalanine residue anchors flexible tail onto core domain; ANK3-DD exists as monomer in solution.
Here, we show that ANK3 gene expression in blood is significantly increased in bipolar disorder and schizophrenia compared with healthy controls.
Kidney AE1 (show SLC4A1 Antibodies) actually associates with epithelial ankyrin-G and renal ammonium transporter RhBG, which also binds ankyrin-G.
This study demonistrated that ANK3 Bipolar disorder-associated variant rs139972937, responsible for an asparagine to serine. change (p = 0.042).
Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats\; a central region with a highly conserved spectrin binding domain\; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.
, ankyrin 3, node of Ranvier (ankyrin G)
, ankyrin 3, node of Ranvier (ankyrin G)-like
, brain-specific ankyrin-G
, ankyrin G119