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ANKRD26 encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Additionally we are shipping ANKRD26 Kits (1) and and many more products for this protein.
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Human Polyclonal ANKRD26 Primary Antibody for IHC, ELISA - ABIN1534639
Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: The DNA sequence and comparative analysis of human chromosome 10. ... in Nature 2004
Deletion of the C-terminus of the protein encoded by Ankrd26 leads to changes in primary cilia in the brain, resulting in the disruption of the function of the melanocortin pathway and the HPA (show HPSE Antibodies) axis and leading to excessive food intake and obesity.
Data indicate that Ankrd26 is involved in regulation of food intake and in regulation of insulin/insulin (show INS Antibodies) receptor (show INSR Antibodies) signaling in white adipose tissue; partial inactivation of Ankrd26 leads to obesity and, thus, to diabetes type 2.
conclude that Ankrd26 gene disruption promotes adipocyte differentiation at both the progenitor commitment and differentiation steps and that ERK (show EPHB2 Antibodies) activation plays a role in this process
obesity and gigantism may be caused by a disruption of the Ankrd26 gene
Molecular analysis identified a mutation located in the promoter of the ankyrin repeat domain 26 (ANKRD26) gene, c.-127A>T in normocytic thrombocytopenia.
thrombocytopenia with 5'UTR (show UTS2R Antibodies) ANKRD26 gene mutation must be considered in case of a constitutional isolated thrombocytopenia, with a low bleeding tendency, associated with autosomal dominant transmission and normal platelet volume.
WASP (show WASL Antibodies), RUNX1 (show RUNX1 Antibodies), and ANKRD26 genes are important for normal TPO (show THPO Antibodies) signaling and the network underlying thrombopoiesis.
The study supports the association of ANKRD26 mutations with thrombocytopenia 2 and a predisposition to myeloid malignancies.
ANKRD26 regulatory region mutations induce MAPK (show MAPK1 Antibodies) hyperactivation in familial thrombocytopenia
Studies indicate that ANKRD26-RT is an insidious form of inherited thrombocytopenias that exposes patients to a low risk of bleeding but predisposes them to hematologic myeloid malignancies.
Ubiquitin/proteasome-rich particulate cytoplasmic structures are a characteristic feature of ANKRD26-related thrombocytopenia platelets and megakaryocytes.
The ANKRD26-related thrombocytopenia has to be taken into consideration in the differential diagnosis of isolated thrombocytopenias.
mutations in the 5' UTR (show UTS2R Antibodies) of ANKRD26 are implicated in thrombocytopenia 2.
This gene encodes a protein containing N-terminal ankyrin repeats which function in protein-protein interactions. Mutations in this gene are associated with autosomal dominant thrombocytopenia-2. Pseudogenes of this gene are found on chromosome 7, 10, 13 and 16. Multiple transcript variants encoding different isoforms have been found for this gene.
, ankyrin repeat domain 26
, ankyrin repeat domain-containing protein 26