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May be a Rab21 guanine exchange factor and regulate endosome dynamics.. Additionally we are shipping ANKRD27 Antibodies (23) and ANKRD27 Proteins (3) and many more products for this protein.
VARP regulates endosomal trafficking and and retromer-mediated endosome-to-plasma membrane sorting of transmembrane proteins by binding to rab (show HRB ELISA Kits) GTP-Binding (show RND2 ELISA Kits) Proteins and R-SNARE (show YKT6 ELISA Kits) VAMP7 (show VAMP7 ELISA Kits) [review].
Eosinophilic esophagitis was associate with increased expression of ANKRD27.
VAMP7 (show VAMP7 ELISA Kits)-SNARE (show NAPA ELISA Kits) motif is trapped between Varp and the VAMP7 (show VAMP7 ELISA Kits) longin domain, and hence Varp kinetically inhibits the ability of VAMP7 (show VAMP7 ELISA Kits) to form SNARE (show NAPA ELISA Kits) complexes
Varp physically interacts with Rab38, and preferentially binds to the active GTP-bound form of Rab38 both in vitro and in vivo.
show that TI-VAMP (show VAMP7 ELISA Kits) interacts with the Vps9 domain and ankyrin-repeat-containing protein Varp, a guanine nucleotide exchange factor (show RASGRF1 ELISA Kits) of the small GTPase (show RACGAP1 ELISA Kits) Rab21 (show RAB21 ELISA Kits), through a specific domain herein called the interacting domain.
RACK1 (show GNB2L1 ELISA Kits) competes with Rab40C for binding to the ANKR2 domain of Varp and regulates dendrite outgrowth through stabilization of Varp in mouse melanocytes
both the Rab32 (show RAB32 ELISA Kits)/38 binding activity and VAMP7 (show VAMP7 ELISA Kits) binding activity of Varp are essential for trafficking of Tyrp1 (show TYRP1 ELISA Kits) in melanocytes but activation of Rab21 (show RAB21 ELISA Kits) by the VPS9 domain is not necessary for Tyrp1 (show TYRP1 ELISA Kits) trafficking
Varp is a potential Rab21 (show RAB21 ELISA Kits) guanine nucleotide exchange factor (show ARHGEF12 ELISA Kits) and might regulate endosome dynamics in vivo
Varp functions as the Rab32 (show RAB32 ELISA Kits)/38 effector that controls trafficking of Tyrp1 (show TYRP1 ELISA Kits) in melanocytes.
May be a Rab21 guanine exchange factor and regulate endosome dynamics.
VPS9 domain-containing protein
, VPS9-ankyrin-repeat protein
, Vps9 domain and ankyrin-repeat-containing protein
, ankyrin repeat domain-containing protein 27
, VPS9-ankyrin repeat-containing protein
, mFLJ00040 protein