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ANKHD1 encodes a protein with multiple ankyrin repeat domains and a single KH-domain. Additionally we are shipping ANKHD1 Antibodies (45) and ANKHD1 Proteins (2) and many more products for this protein.
ANKHD1 may be an oncogene (show RAB1A ELISA Kits) and participate in the leukemia cell phenotype.
Data suggest an association of ANKHD1 (Ankyrin repeat and KH domain-containing protein 1) protein with p21 (WAF1/CIP1 (show CDKN1A ELISA Kits)) promoter region.
ANKHD1 is a positive regulator of YAP1 (show YAP1 ELISA Kits) and promotes cell growth and cell cycle progression through Cyclin A (show CCNA2 ELISA Kits) upregulation.
These data suggest that ANKHD1 might have a role in multiple myeloma cell proliferation and cell cycle progression by regulating expression of p21 (show CDKN1A ELISA Kits).
VBARP is a novel splice variant of ANKHD1 and may play a role in cellular apoptosis (antiapoptotic) and cell survival pathway(s
These findings suggest a role for ANKHD1 as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells.
This gene encodes a protein with multiple ankyrin repeat domains and a single KH-domain. The protein is thought to function as a scaffolding protein, and it may be involved in the regulation of caspases and thereby play an antiapoptotic role in cell survival. Alternative splicing results in multiple transcript variants, one of which generates a fusion transcript (MASK-BP3) with the downstream eIF4E-binding protein 3 (EIF4EBP3) gene, resulting in a protein comprised of the ANKHD1 sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.
ankyrin repeat and KH domain-containing protein 1
, multiple ankyrin repeats, single KH-domain homolog
, HIV-1 Vpr-binding ankyrin repeat protein