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The protein encoded by ASB11 is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. Additionally we are shipping ASB11 Kits (22) and ASB11 Antibodies (20) and many more products for this protein.
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d-Asb11 is a component in the regulation of Delta-Notch (show NOTCH1 Proteins) signalling, important in fine-tuning the lateral inhibition gradients between DeltaA and Notch (show NOTCH1 Proteins) through a cell non-autonomous mechanism.[d-Asb11]
We conclude that d-Asb11 is a novel regulator of the neuronal progenitor compartment size by maintaining the neural precursors in the proliferating undifferentiated state possibly through the control of SoxB1 transcription factors.
Zebrafish homozygous for a hypomorphic Asb11 mutation are impaired in muscle progenitor expansion and myotome formation.
Data show that the d-Asb11 cullin box is required for both canonical Notch (show NOTCH1 Proteins) signaling and proper neurogenesis.
ASB11 is a novel endoplasmic reticulum-associated ubiquitin ligase with the ability to interact and promote the ubiquitination of Ribophorin 1 (show RPN1 Proteins), an integral protein of the oligosaccharyltransferase (OST (show DDOST Proteins)) glycosylation complex.
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ankyrin repeat and SOCS box-containing 11
, ankyrin repeat and SOCS box-containing protein 11
, ankyrin repeat and SOCS box containing protein a
, ankyrin repeat and SOCS box protein 9
, Ankyrin repeat and SOCS box protein 11
, ankyrin repeat and SOCS box protein 11
, ankyrin repeat domain-containing SOCS box protein ASB11