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Ankyrin Repeat and SOCS Box-Containing 2 Proteins (ASB2)

ASB2 encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. Additionally we are shipping ASB2 Antibodies (45) and ASB2 Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ASB2 51676 Q96Q27
ASB2 65256 Q8K0L0
ASB2 299266 Q5U2S6
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Top ASB2 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,835.33
Details

ASB2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Ankyrin Repeat and SOCS Box-Containing 2 (ASB2) Interaction Partners

Human Ankyrin Repeat and SOCS Box-Containing 2 (ASB2) interaction partners

  1. Using ASB2 conditional knockout mice.

  2. Phosphorylation of serine 323 of ASB2 alpha by Erk (show EPHB2 Proteins) kinases is critical for ASB2alpha-mediated degradation of FLNA (show FLNA Proteins).

  3. data therefore reveal ubiquitin acceptor sites in FLNa (show FLNA Proteins) and establish that ASB2alpha-mediated effects on cell spreading are due to loss of filamins.

  4. Data show that neither endogenous nor exogenously expressed ASB2alpha induces degradation of JAK (show JAK3 Proteins) proteins in hematopoietic cells

  5. A model whereby ASB2 contributes to hematopoietic differentiation, in part, through MLL (show MLL Proteins) degradation and HOX (show MSH2 Proteins) gene down-regulation.

  6. By shifting monomeric E3 ligase complexes to dimeric forms through activation of Asb2 transcription, Notch (show NOTCH1 Proteins) could effectively control the turnover of a variety of substrates and it exerts diverse effects on cell proliferation and differentiation.

  7. ASB2 may regulate hematopoietic cell differentiation by modulating cell spreading and actin remodeling through targeting of filamins A and B for degradation.

Mouse (Murine) Ankyrin Repeat and SOCS Box-Containing 2 (ASB2) interaction partners

  1. This study identifies desmin (show DES Proteins) as a new Asb2b target for proteasomal degradation in cardiomyocytes and suggests that accumulation of desmin (show DES Proteins) could contribute to UPS impairment in Hypertrophic cardiomyopathy mice and patients

  2. ASB2(-/-) immature dendritic cells exhibit reduced matrix-degrading function leading to defective migration.

  3. ASB2beta is part of an active E3 ubiquitin ligase (show MUL1 Proteins) complex and targets the actin-binding protein (show PFN1 Proteins) filamin B (show FLNB Proteins) for proteasomal degradation.

ASB2 Protein Profile

Protein Summary

This gene encodes a member of the ankyrin repeat and SOCS box-containing (ASB) protein family. These proteins play a role in protein degradation by coupling suppressor of cytokine signalling (SOCS) proteins with the elongin BC complex. The encoded protein is a subunit of a multimeric E3 ubiquitin ligase complex that mediates the degradation of actin-binding proteins. This gene plays a role in retinoic acid-induced growth inhibition and differentiation of myeloid leukemia cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with ASB2

  • ankyrin repeat and SOCS box containing 2 (ASB2)
  • ankyrin repeat and SOCS box-containing 2 (ASB2)
  • ankyrin repeat and SOCS box-containing 2 (Asb2)
  • 1110008E15Rik protein
  • ASB-2 protein
  • ASB2 protein

Protein level used designations for ASB2

ankyrin repeat and SOCS box-containing 2 , ankyrin repeat and SOCS box protein 2-like , ankyrin repeat and SOCS box protein 2 , ankyrin repeat and SOCS box-containing protein 2a , ASB-2 , ankyrin repeat and SOCS box-containing protein 2 , ankyrin repeat-containing SOCS box protein 2

GENE ID SPECIES
100064381 Equus caballus
423428 Gallus gallus
467538 Pan troglodytes
490836 Canis lupus familiaris
699882 Macaca mulatta
100227715 Taeniopygia guttata
100385735 Callithrix jacchus
100451651 Pongo abelii
51676 Homo sapiens
539244 Bos taurus
65256 Mus musculus
299266 Rattus norvegicus
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