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ANXA8 encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. Additionally we are shipping Annexin VIII Antibodies (33) and Annexin VIII Proteins (17) and many more products for this protein.
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Annexin A8 controls leukocyte recruitment to activated endothelial cells via cell surface delivery of CD63 (show CD63 ELISA Kits).
High ANXA8 (show ANXA8L2 ELISA Kits) expression is associated with pancreatic cancer.
Claudin 18 (show CLDN18 ELISA Kits) and annexin A8 are frequently highly overexpressed in infiltrating ductal adenocarcinomas.
Define a distinct bone-dependent genetic program associated with terminal osteoclast differentiation and identified Anxa8 as a gene strongly induced late in osteoclast differentiation, regulating formation of the cell's characteristic actin ring.
Annexin A8 is involved in mouse mammary gland involution and progression of human breast cancer
binds Ca2+-dependently and with high specificity to phosphatidylinositol (4,5)-bisphosphate (PtdIns(4,5)P2) and is also capable of interacting with F-actin
Data suggest that defective transport through the late endocytic pathway and imbalanced signaling in the absence of annexin A8 results from disturbed association of late endosomal membranes with actin and impaired endosome motility.
Annexin A8 identifies a subpopulation of transiently quiescent c-kit (show KIT ELISA Kits) positive luminal progenitor cells of the ductal mammary epithelium.
ANXA8 protein is most abundant in stratified epithelia of the postnatal mouse. Its location in the suprabasal layers suggests that ANXA8 may be associated with the terminal differentiation of epithelial cells in these tissues.
Annexin VIII was expressed by growth plate, not epiphyseal, chondrocytes. In osteoarthritic cartilage, it was seen in a subset of mid- to deep zone chondrocytes & the matrix around them; none was detected in normal articular cartilage.
This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10.
annexin A8-like 1
, annexin A8-like 2
, annexin A8
, annexin VIII
, vascular anticoagulant-beta
, annexin 8
, annexin A8-like protein 1