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Acts as a calcium-activated chloride channel. Additionally we are shipping ANO1 Proteins (8) and ANO1 Kits (1) and many more products for this protein.
Showing 10 out of 339 products:
Human Monoclonal ANO1 Primary Antibody for IHC (p) - ABIN1689062
Michelucci, Chiappetta, Cacciotti, Veccia, Astri, Leopizzi, Prosperi Porta, Petrozza, Della Rocca, Bevilacqua, Cavazzana, Di Cristofano: The KIT Exon 11 Stop Codon Mutation in Gastrointestinal Stromal Tumors: What Is the Clinical Meaning? in Gut and liver 2013
Show all 26 Pubmed References
Human Monoclonal ANO1 Primary Antibody for IHC, IHC (fro) - ABIN4305778
Namkung, Yao, Finkbeiner, Verkman: Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011
Show all 2 Pubmed References
Cow (Bovine) Polyclonal ANO1 Primary Antibody for WB - ABIN2775453
Katoh, Katoh: Identification and characterization of TMEM16E and TMEM16F genes in silico. in International journal of oncology 2004
Show all 3 Pubmed References
Human Polyclonal ANO1 Primary Antibody for IHC, WB - ABIN4305781
Li, Wang, Chen, Jiang, Tu, Li, Yin: TMEM16A contributes to angiotensin II-induced cerebral vasoconstriction via the RhoA/ROCK signaling pathway. in Molecular medicine reports 2016
Human Polyclonal ANO1 Primary Antibody for ELISA, ICC - ABIN4305784
Banga, Flaig, Lewis, Winfree, Blazer-Yost: Epinephrine stimulation of anion secretion in the Calu-3 serous cell model. in American journal of physiology. Lung cellular and molecular physiology 2014
TMEM16A expression was enhanced by 24-h treatment of IL-4 (show IL4 Antibodies) in human nasal epithelial cells.
findings demonstrate that Ca2 (show CA2 Antibodies)+ influx via store-operated CRAC channels is essential for CaCC (show CLCA1 Antibodies) activation, chloride secretion, and sweat production in humans and mice.
TMEM16A activation as a sequential, direct, and Vm-dependent binding.
Ano1(0) without EAVK [Ano1(0)DeltaEAVK] has reduced sensitivity for intracellular calcium, attributable to slower kinetics. Differential expression of EAVK may function as a calcium-sensitive switch in the human stomach.
Gains of ANO1 is associated with oropharyngeal squamous cell carcinoma.
DOG1 is a novel marker for identifying intercellular canaliculi and is a potential immunomarker of myoepithelial cells specific to mammary glands, anogenital mammary-like glands and tumors originating therein.
Increase in TMEM16A activity occurred within minutes of exposure to CLCA1 (show CLCA1 Antibodies) or after a short treatment with nocodazole, consistent with the hypothesis that CLCA1 (show CLCA1 Antibodies) stabilizes TMEM16A at the cell surface by preventing its internalization.
These results suggest that ANO1 Cl(-) channels may function as a transcriptional regulator of HER2 (show ERBB2 Antibodies), and ANO1 inhibitors have potential in the treatment of BCA (show BLNK Antibodies) patients with resistance to HER2 (show ERBB2 Antibodies)-targeted therapy.
Endogenous ANO1 was associated with COPB1 (show COPB1 Antibodies) in U251 glioblastoma cells, and silencing of COPB1 (show COPB1 Antibodies) enhanced surface expression and whole-cell currents of ANO1 in these cells. Taken together, these data suggest that COPB1 (show COPB1 Antibodies) negatively regulates ANO1 surface expression.
targeting TMEM16A improves response to biological therapies targeting EGFR (show EGFR Antibodies)/HER family members
ANO1 immunoreactivity was observed in the presynaptic terminals of various retinal neurons, including photoreceptors
In this work we demonstrate that increasing the extracellular proton concentration from 10-10 to 10-5.5 m enabled TMEM16A activation. Furthermore, we show that this effect is voltage independent, caused by changes in the apparent open probability of the channel, and due to protonation of extracellular residue E623
The present study shows that ANO1 and CavL play a central role in the generation of slow waves, phasic contractions and tone in the internal anal sphincter and that this pathway can occur in the absence of stretch
We knocked out Ano1 to varying degrees in interstitial cells of Cajal (ICC) of adult mice. Partial knockout of Ano1 shortened the widths of electrical slow waves and Ca(2 (show CA2 Antibodies)+) transients in myenteric ICC but Ca(2 (show CA2 Antibodies)+) transient synchronicity was preserved. Near-complete knockout was necessary for transient desynchronization and loss of slow waves, indicating a large functional reserve of Ano1 in ICC.
Phosphorylation levels of P38 (show CRK Antibodies) and JNK (show MAPK8 Antibodies) in siRNA-TMEM16A group were lower than that of the Model group. Thus, TMEM16A is one of the critical components of a signal transduction pathway that links renal injury to podocyte apoptosis in DN.
To determine the role of ANO1 in physiological functions.
ANO1/TMEM16A is a significant pathway in pancreatic acinar cells for HCO3 (-) secretion into the lumen.
TMEM16A is a positive regulator of endothelial reactive oxygen species generation via Nox2 (show CYBB Antibodies)-containing NADPH oxidase (show NOX1 Antibodies), which induces endothelial dysfunction and hypertension.
Data indicate that anoctamin channel proteins ANO1 and ANO2 (show ANO2 Antibodies) are expressed in the cerebellum.
Acts as a calcium-activated chloride channel. Required for normal tracheal development (By similarity).
anoctamin 1, calcium activated chloride channel
, Ca-activated chloride channel Tmem16A
, discovered on gastrointestinal stromal tumors protein 1
, oral cancer overexpressed 2
, transmembrane protein 16A (eight membrane-spanning domains)
, tumor-amplified and overexpressed sequence 2
, transmembrane protein 16A