Anoctamin 1, Calcium Activated Chloride Channel Proteins (ANO1)

Acts as a calcium-activated chloride channel. Additionally we are shipping ANO1 Antibodies (341) and ANO1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ANO1 55107 Q5XXA6
ANO1 101772 Q8BHY3
Rat ANO1 ANO1 309135  
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Top ANO1 Proteins at antibodies-online.com

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 60 to 65 Days
$6,052.17
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Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 60 to 65 Days
$8,623.45
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HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

ANO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine) ,
, ,

More Proteins for Anoctamin 1, Calcium Activated Chloride Channel (ANO1) Interaction Partners

Guinea Pig Anoctamin 1, Calcium Activated Chloride Channel (ANO1) interaction partners

Human Anoctamin 1, Calcium Activated Chloride Channel (ANO1) interaction partners

  1. TMEM16A expression was enhanced by 24-h treatment of IL-4 (show IL4 Proteins) in human nasal epithelial cells.

  2. findings demonstrate that Ca2 (show CA2 Proteins)+ influx via store-operated CRAC channels is essential for CaCC (show CLCA1 Proteins) activation, chloride secretion, and sweat production in humans and mice.

  3. TMEM16A activation as a sequential, direct, and Vm-dependent binding.

  4. Ano1(0) without EAVK [Ano1(0)DeltaEAVK] has reduced sensitivity for intracellular calcium, attributable to slower kinetics. Differential expression of EAVK may function as a calcium-sensitive switch in the human stomach.

  5. Gains of ANO1 is associated with oropharyngeal squamous cell carcinoma.

  6. DOG1 is a novel marker for identifying intercellular canaliculi and is a potential immunomarker of myoepithelial cells specific to mammary glands, anogenital mammary-like glands and tumors originating therein.

  7. Increase in TMEM16A activity occurred within minutes of exposure to CLCA1 (show CLCA1 Proteins) or after a short treatment with nocodazole, consistent with the hypothesis that CLCA1 (show CLCA1 Proteins) stabilizes TMEM16A at the cell surface by preventing its internalization.

  8. These results suggest that ANO1 Cl(-) channels may function as a transcriptional regulator of HER2 (show ERBB2 Proteins), and ANO1 inhibitors have potential in the treatment of BCA (show BLNK Proteins) patients with resistance to HER2 (show ERBB2 Proteins)-targeted therapy.

  9. Endogenous ANO1 was associated with COPB1 (show COPB1 Proteins) in U251 glioblastoma cells, and silencing of COPB1 (show COPB1 Proteins) enhanced surface expression and whole-cell currents of ANO1 in these cells. Taken together, these data suggest that COPB1 (show COPB1 Proteins) negatively regulates ANO1 surface expression.

  10. targeting TMEM16A improves response to biological therapies targeting EGFR (show EGFR Proteins)/HER family members

Mouse (Murine) Anoctamin 1, Calcium Activated Chloride Channel (ANO1) interaction partners

  1. findings demonstrate that Ca2 (show CA2 Proteins)+ influx via store-operated CRAC channels is essential for CaCC (show CLCA1 Proteins) activation, chloride secretion, and sweat production in humans and mice.

  2. We knocked out Ano1 to varying degrees in interstitial cells of Cajal (ICC) of adult mice. Partial knockout of Ano1 shortened the widths of electrical slow waves and Ca(2 (show CA2 Proteins)+) transients in myenteric ICC but Ca(2 (show CA2 Proteins)+) transient synchronicity was preserved. Near-complete knockout was necessary for transient desynchronization and loss of slow waves, indicating a large functional reserve of Ano1 in ICC.

  3. Phosphorylation levels of P38 (show CRK Proteins) and JNK (show MAPK8 Proteins) in siRNA-TMEM16A group were lower than that of the Model group. Thus, TMEM16A is one of the critical components of a signal transduction pathway that links renal injury to podocyte apoptosis in DN.

  4. To determine the role of ANO1 in physiological functions.

  5. ANO1/TMEM16A is a significant pathway in pancreatic acinar cells for HCO3 (-) secretion into the lumen.

  6. TMEM16A is a positive regulator of endothelial reactive oxygen species generation via Nox2 (show CYBB Proteins)-containing NADPH oxidase (show NOX1 Proteins), which induces endothelial dysfunction and hypertension.

  7. Data indicate that anoctamin channel proteins ANO1 and ANO2 (show ANO2 Proteins) are expressed in the cerebellum.

  8. Ano1 may play a role in the pathophysiological processes during ischaemia in heart, and therefore, Ano1 might be a potential therapeutic target to prevent ischaemic damage

  9. Thegenetic ablation of TMEM16A did not seem to affect the maturation of olfactory sensory neurons and their ciliary layer.

  10. Suggest Ca(2 (show CA2 Proteins)+)-dependent push-pull conformational change as a key electromechanical movement for gating the ANO1 channel.

ANO1 Protein Profile

Protein Summary

Acts as a calcium-activated chloride channel. Required for normal tracheal development (By similarity).

Gene names and symbols associated with ANO1

  • anoctamin 1, calcium activated chloride channel (Ano1)
  • anoctamin 1, calcium activated chloride channel (ANO1)
  • DOG1 protein
  • ORAOV2 protein
  • TAOS2 protein
  • Tmem16a protein

Protein level used designations for ANO1

anoctamin 1, calcium activated chloride channel , Ca-activated chloride channel Tmem16A , anoctamin-1 , discovered on gastrointestinal stromal tumors protein 1 , oral cancer overexpressed 2 , transmembrane protein 16A (eight membrane-spanning domains) , tumor-amplified and overexpressed sequence 2 , transmembrane protein 16A

GENE ID SPECIES
100529098 Cavia porcellus
55107 Homo sapiens
423144 Gallus gallus
532126 Bos taurus
101772 Mus musculus
309135 Rattus norvegicus
611698 Canis lupus familiaris
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