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ANO6 encodes a multi-pass transmembrane protein that belongs to the anoctamin family. Additionally we are shipping Anoctamin 6 Antibodies (32) and Anoctamin 6 Proteins (6) and many more products for this protein.
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ANO6 produces volume-regulated anion currents and controls cell volume in four unrelated cell types.
deficiency in Ano6 resulted in reduced viability with increased bleeding time
Although broadly expressed, Ano6 has no role in intestinal cholinergic Cl- secretion.
Ano6 mediates effects essential for innate immunity downstream of P2X7 (show P2RX7 ELISA Kits) receptors in macrophages.
TMEM16F is required for phosphatidylserine exposure and microparticle release in activated mouse platelets.
Ano6 and Ano2 (show ANO2 ELISA Kits) proteins co-localize in the ciliary membrane microdomains, which indicates a role for Ano6 in olfactory signaling.
human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 requi (show SLC8A1 ELISA Kits)res Ano6 to efficiently translocate Ca(2+) out (show CA2 ELISA Kits) of osteoblasts into the calcifying bone matrix
Ano6 plays an essential role in C2C12 myoblast proliferation
findings show TMEM16A (show ANO1 ELISA Kits) and TMEM16F have an important function in cell migration-TMEM16A (show ANO1 ELISA Kits) in directional migration, TMEM16F in determination of speed of migration; conclude that TMEM16A (show ANO1 ELISA Kits) and TMEM16F channels have a distinct impact on steering and motor mechanisms of migrating ELA cells
TMEM16A (show ANO1 ELISA Kits) and -16F use a similar mechanism for sorting to plasma membrane and protein stabilization, but their functional domains significantly differ
TMEM16F modifies viability of Human Embryonic Kidney cells via its function as a phospholipid scramblase and activation of AKT (show AKT1 ELISA Kits) signaling pathways.
Ion channel and lipid scramblase activity associated with expression of TMEM16F/ANO6 isoforms
ANO6 is highly expressed in apoptotic cyst epithelial cells of human polycystic kidneys.
Homology modeling shows that the scramblase domain forms an unusual hydrophilic cleft that faces the lipid bilayer and may function to facilitate translocation of phospholipid between membrane leaflets.
using human osteoblasts and osteoblasts from Ano6(-/-) and WT mice, we demonstrate that NCX1 (show SLC8A1 ELISA Kits) requires Ano6 to efficiently translocate Ca(2 (show CA2 ELISA Kits)+) out of osteoblasts into the calcifying bone matrix
Anoo6 induces a chloride ion conductance along with a smaller nonselective cation conductance that is activated either calcium ion dependently (ionomycin) or calcium independently(fas receptor (show FAS ELISA Kits)), but not during mitochondrial apoptosis.
TMEM16F is an essential component of a divalent calcium ion-activated Cl- channel with a divalent calcium ion sensitivity that is distinct from that of TMEM16A (show ANO1 ELISA Kits)/B and not related to volume-sensitive outwardly rectifying Cl- channel (VSOR) activity.
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, transmembrane protein 16F
, abnormal X segregation-like
, Transmembrane protein 16F
, SCAN channel
, small-conductance calcium-activated nonselective cation channel