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Required for MUC2 post-transcriptional synthesis and secretion. Additionally we are shipping AGR2 Antibodies (237) and AGR2 Proteins (24) and many more products for this protein.
Showing 10 out of 25 products:
Human AGR2 ELISA Kit for Sandwich ELISA - ABIN415308
Kani, Malihi, Jiang, Wang, Wang, Ruderman, Agus, Mallick, Gross: Anterior gradient 2 (AGR2): blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype. in The Prostate 2013
Show all 7 references for ABIN415308
Agr2 is essential for terminal differentiation of intestinal goblet cells in zebrafish embryos
Both phylogenetic and syntenic analyses indicate that zebrafish agr2 is the orthologue of human AGR2 and mouse Agr2 genes.
Results show that AGR2 is O-glycosylated upon secretion from human and rat cell lines, and that this form of the protein is released from healthy cells and not as a result of cell lysis.
Nearly all NSCLC tumors show AGR2 expression. Lung cancer expression of AGR2 has prognostic value for younger patients.
These data together identify the single cysteine of AGR2 as an oxidant responsive moiety that regulates its propensity for oxidation and its monomeric-dimeric state.
The prognostic impact of AGR2 expression could be related to treatment outcome in estrogen receptor (show ESR1 ELISA Kits)-positive breast cancers and/or its metastasis-promoting effects.
analysis of molecular characteristics, function, and regulation of AGR2 in cancer[review]
AGR2 was higher in HNSCC than in normal oral mucosa. High levels were associated with the T category, pathological grade and lymphatic metastasis. AGR2 expression increased in recurring HNSCC after radiotherapy or cisplatin-based chemotherapy.
The mechanism linking the IGF-1 (show IGF1 ELISA Kits)/insulin (show INS ELISA Kits) signal and AGR2 promoter activation is important.
Data show the potential usability of anterior gradient homolog 3 (AGR3 (show AGR3 ELISA Kits)) and anterior gradient homolog 2 (AGR2) as biomarkers for blood-based early detection of breast cancer.
Our findings, for the first time, describe AGR2 as an important regulator in chemical hypoxia-induced doxorubicin resistance in breast cancer cells
Relying on available data and in silico analyses, study shows that AGR2 and AGR3 (show AGR3 ELISA Kits) proteins are co-expressed or uncoupled in context-dependent manners in diverse carcinomas and healthy tissues.
EGFR (show EGFR ELISA Kits)-mediated signaling in NCI-H460 cells is disrupted with reduced AGR2 expression.
AGR2 has both intracellular and extracellular effects in the intestine
Results indicate that DNA methylation (show HELLS ELISA Kits) within the AGR2 promoter modulates more aggressive cancer cell phenotypes.
It was concluded that: the expression of AGR2 protein was significantly higher in asthmatic mice as compared with their normal counterparts; the expression was obviously related to the expression of Muc5ac protein and IL-13 (show IL13 ELISA Kits).
Agr2 consequently serves to maintain the balance between proliferating and differentiated epithelial cells.
Agr2 facilitates normal lobuloalveolar development by regulating mammary epithelial cell proliferation; we found no effects on apoptosis in Agr2(-/-) mammary epithelial cells.
Loss of Foxp1 (show FOXP1 ELISA Kits)/4 in the developing lung and in postnatal secretory epithelium leads to ectopic activation of the goblet cell fate program, in part, through de-repression of the protein disulfide isomerase (show P4HB ELISA Kits) anterior gradient 2 (Agr2).
studies implicate Agr2 in intestinal homeostasis and ER stress and suggest a role in the etiology of inflammatory bowel disease
AGR2 may be important for the growth and development of the intestine as well as esophageal adenocarcinomas.
Overexpression of Agr2 is associated with asthma.
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth (By similarity).
anterior gradient 3
, anterior gradient 2 homolog
, anterior gradient homolog 2
, anterior gradient protein 2 homolog
, protein disulfide isomerase family A, member 17
, secreted cement gland homolog
, secreted cement gland protein XAG-2 homolog
, protein Gob-4
, anterior gradient 2 homologue