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Required for MUC2 post-transcriptional synthesis and secretion. Additionally we are shipping AGR2 Kits (28) and AGR2 Proteins (25) and many more products for this protein.
Showing 10 out of 183 products:
Human Monoclonal AGR2 Primary Antibody for ELISA, WB - ABIN564604
Zhao, Lee, Brown, Molloy, Marx, Pavlakis, Boyer, Stockler, Kaplan, Breit, Sutherland, Henshall, Horvath: Identification of candidate biomarkers of therapeutic response to docetaxel by proteomic profiling. in Cancer research 2009
Show all 9 Pubmed References
Polyclonal AGR2 Primary Antibody for IHC (p) - ABIN540789
Petek, Windpassinger, Egger, Kroisel, Wagner: Localization of the human anterior gradient-2 gene (AGR2) to chromosome band 7p21.3 by radiation hybrid mapping and fluorescencein situ hybridisation. in Cytogenetics and cell genetics 2000
Show all 2 Pubmed References
Polyclonal AGR2 Primary Antibody for IHC (p) - ABIN540424
Fletcher, Patel, Tyson, Adam, Schenker, Loader, Daviet, Legrain, Parekh, Harris, Terrett: hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. in British journal of cancer 2003
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Human Monoclonal AGR2 Primary Antibody for ELISA, WB - ABIN523969
Bergström, Berg, Rodríguez-Piñeiro, Stecher, Johansson, Hansson: AGR2, an endoplasmic reticulum protein, is secreted into the gastrointestinal mucus. in PLoS ONE 2014
Agr2 is essential for terminal differentiation of intestinal goblet cells in zebrafish embryos
Both phylogenetic and syntenic analyses indicate that zebrafish agr2 is the orthologue of human AGR2 and mouse Agr2 genes.
The authors conclude that extracellular AGR2 plays an extracellular role independent of its endoplasmic reticulum function and elucidate this gain-of-function as a novel and unexpected critical extracellular matrix microenvironmental pro-oncogenic regulator of epithelial morphogenesis and tumorigenesis.
High AGR2 expression is associated with ovarian cancer.
This study demonstrates that AGR2, which is overexpressed in a variety of human cancers and provides a poor prognosis, up-regulates DUSP10 (show DUSP10 Antibodies) which subsequently inhibits p38 MAPK (show MAPK14 Antibodies) and prevents p53 (show TP53 Antibodies) activation by phosphorylation.
A direct impact of mTOR (show FRAP1 Antibodies) signalling on AGR2 3'UTR (show UTS2R Antibodies) shortening associated with increased protein synthesis was found, which led to the identification of a novel molecular mechanism involved in upregulation of AGR2 levels in mTOR (show FRAP1 Antibodies)-activated cells via modulating the 3'UTR (show UTS2R Antibodies) length of AGR2 mRNA.
Suggest elevated AGR2 as a candidate tamoxifen-dependent mechanism of action responsible for increased incidence of endometrial cancer.
AGR2 could also be upregulated in hormone-independent manner. AGR2 expression was shown to be significantly increased in HER2 (show ERBB2 Antibodies) positive breast tumors on both the mRNA and the protein level.
Our findings demonstrated recombinant human endostatin (show COL18A1 Antibodies)-gold nanoparticles might normalize vessels by interfering anterior gradient 2-mediated angiogenesis in metastatic colorectal cancer.
AGR2, through interaction with ER-alpha (show ESR1 Antibodies), enhances fulvestrant resistance and IGF-1 (show IGF1 Antibodies)-induced carcinogenesis in breast cancer cells.
AGR2 inhibits TNF-alphainduced Caco-2 cell hyperpermeability by regulating TJ and that this protective mechanism may be promoted by inhibition of NF-kappaB p65-mediated activation of the MLCK/p-MLC signaling pathway.
our study showed the important role of AGR2 in regulating EMT (show ITK Antibodies) of glioblastoma. SDF-1 (show CXCL12 Antibodies) signaling induced the expression of AGR2 to control the progress of EMT (show ITK Antibodies) in the progression of glioblastoma.
AGR2 accelerates skin wound healing through regulation of cell migration.
AGR2 induced in ER-stressed and inflammatory pre-neoplastic pancreas is a potential marker of cancer progenitor cells with an important functional role in PDAC initiation.
impact of AGR2 expression and EGFR (show EGFR Antibodies) signaling on tissue regeneration
EGFR (show EGFR Antibodies)-mediated signaling in NCI-H460 cells is disrupted with reduced AGR2 expression.
AGR2 has both intracellular and extracellular effects in the intestine
Results indicate that DNA methylation (show HELLS Antibodies) within the AGR2 promoter modulates more aggressive cancer cell phenotypes.
It was concluded that: the expression of AGR2 protein was significantly higher in asthmatic mice as compared with their normal counterparts; the expression was obviously related to the expression of Muc5ac protein and IL-13 (show IL13 Antibodies).
Agr2 consequently serves to maintain the balance between proliferating and differentiated epithelial cells.
Agr2 facilitates normal lobuloalveolar development by regulating mammary epithelial cell proliferation; we found no effects on apoptosis in Agr2(-/-) mammary epithelial cells.
Loss of Foxp1 (show FOXP1 Antibodies)/4 in the developing lung and in postnatal secretory epithelium leads to ectopic activation of the goblet cell fate program, in part, through de-repression of the protein disulfide isomerase (show P4HB Antibodies) anterior gradient 2 (Agr2).
Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells. Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth (By similarity).
anterior gradient 3
, anterior gradient 2 homolog
, anterior gradient homolog 2
, anterior gradient protein 2 homolog
, protein disulfide isomerase family A, member 17
, secreted cement gland homolog
, secreted cement gland protein XAG-2 homolog
, protein Gob-4
, anterior gradient 2 homologue