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ANTXR2 encodes a receptor for anthrax toxin. Additionally we are shipping ANTXR2 Proteins (14) and ANTXR2 Kits (9) and many more products for this protein.
Showing 10 out of 49 products:
Cow (Bovine) Polyclonal ANTXR2 Primary Antibody for EIA, WB - ABIN498028
Deuquet, Abrami, Difeo, Ramirez, Martignetti, van der Goot: Systemic hyalinosis mutations in the CMG2 ectodomain leading to loss of function through retention in the endoplasmic reticulum. in Human mutation 2009
blood pressure measured under anesthesia in Antxr2 siRNA-injected mice rose significantly compared with that of the controls, suggesting that ANTXR2 is a causative gene in the human 4q21 GWAS-blood pressure locus.
Silencing CMG2 using targeted siRNAs provided almost complete protection against anthrax lethal toxin-induced cytotoxicity and death in murine and human macrophages.
we have discovered that ANTXR1 (show ANTXR1 Antibodies) and ANTXR2 function as positive regulators of MT1-MMP (show MMP14 Antibodies) activity.
these results demonstrate that CMG2 is not required for normal mouse embryonic development but is indispensable for murine parturition
This work demonstrates that anthrax toxin uptake through CMG2 and the resulting impairment of myeloid cells are essential to anthrax infection.
ANTXR2/CMG2 functions to promote endothelial proliferation and morphogenesis during sprouting angiogenesis, consistent with the endothelial expression of ANTXR2/CMG2 in several vascular beds.
Cytoplasmic delivery of lethal factor by anthrax toxin receptor 2 was mediated by cathepsin B (show CTSB Antibodies).
because protective antigen binds to CMG2 with much higher affinity than it does to TEM8 (show ANTXR1 Antibodies), a lower pH is needed to attenuate CMG2 binding to allow pore formation; toxin can form pores at different points in the endocytic pathway
The mRNA transcripts of both receptors, ANTXR1 (show ANTXR1 Antibodies) and ANTXR2 were detected in J774A.1 cells and mouse tissues suggesting that anthrax edema toxin and B. anthracis Sterne spore are involved in the ANTXR mRNA regulation in host cells.
Data show that the lethality of anthrax toxin for mice is mostly mediated by CMG2 and that TEM8 (show ANTXR1 Antibodies) plays only a minor role.
The disulfide bond Cys255-Cys279 in the immunoglobulin-like domain of ANTXR2 is required for membrane insertion of anthrax protective antigen pore.
CMG2 glycosylation provides a buffer towards genetic variation by promoting folding of the protein in the ER lumen.
Results show that CMG2 has been shown to be able to regulate the proliferation and tubule formation of endothelial cells, but not the migration.
Ankylosing spondylitis is associated with the anthrax toxin receptor 2 gene.
data suggested that cellular cholesterol regulated ANTXR2-dependent activation of MMP-2 (show MMP2 Antibodies) via ERK1/2 (show MAPK1/3 Antibodies) phosphorylation in neuroglioma U251 cell.
Fused the ANTXR2 ectodomain to the C-terminus of bacterial Trigger Factor (TF), and the fusion protein was overly expressed as a dominant soluble protein in E coli.
Loss of CMG2 expression is associated with breast cancer progression.
A protective antigen mutation increases the pH threshold of anthrax toxin receptor 2-mediated pore formation
Investigated the kinetics of binding as a function of pH to the full-length monomeric anthrax protective antigen(PA)and to two variants to CMG2. Results suggest that for the full-length PA, low pH increases the binding affinity.
This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene.
anthrax toxin receptor 2
, capillary morphogenesis gene 2 protein
, capillary morphogenesis protein 2