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The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Additionally we are shipping Anti-Soluble Liver Antigen Antibodies (37) and Anti-Soluble Liver Antigen Kits (15) and many more products for this protein.
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Epileptic encephalopathy with burst suppression without brain malformations is associated with pathogenic variation in SEPSECS.
The progression of clinical symptoms in these families is evidently slower than in previously reported cases, and the cerebellar atrophy milder by brain MRI, indicating that SEPSECS mutations are also involved in milder late-onset cerebellar atrophy.
results suggest SEPSECS as a candidate gene for progressive encephalopathies with lactate elevation.
Data suggest SEPSECS silencing in placental trophoblasts inhibits proliferation, induces apoptosis, and reduces production of progesterone/chorionic gonadotropin (P/hCG (show CGA Proteins)); SEPSECS over-expression promotes cell proliferation and secretion of P/hCG (show CGA Proteins).
Three SNPs in SEPSECS and SEPHS1 (show SEPHS1 Proteins) were found to significantly interact with serum selenium level and Crohn's Disease.
The human SepSecS protein is also known as soluble liver antigen/liver pancreas (SLA/LP), which represents one of the antigens of autoimmune hepatitis.
SepSecS mutations cause autosomal-recessive progressive cerebellocerebral atrophy in Jews of Iraqi and Moroccan ancestry.
crystal structure of tRNA(Sec) in complex with SepSecS, phosphoserine, and thiophosphate, together with in vivo and in vitro enzyme assays, supports a pyridoxal phosphate-dependent mechanism of Sec-tRNA(Sec) formation
SECp43 and SLA (show HEPH Proteins) have roles in selenoprotein synthesis [soluble liver antigen]
The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).
O-phosphoseryl-tRNA(Sec) selenium transferase
, SLA/LP autoantigen
, UGA suppressor tRNA-associated protein
, liver-pancreas antigen
, soluble liver antigen
, soluble liver antigen/liver pancreas antigen
, tRNA(Ser/Sec)-associated antigenic protein
, sec synthase
, selenocysteine synthase
, selenocysteinyl-tRNA(Sec) synthase
, sep-tRNA:Sec-tRNA synthase
, uncharacterized protein LOC679383