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Apelin Proteins (APLN)

APLN encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. Additionally we are shipping Apelin Antibodies (89) and Apelin Kits (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
APLN 30878 Q9R0R4
APLN 8862 Q9ULZ1
APLN 58812 Q9R0R3
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Top Apelin Proteins at

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag,MBP tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rat His tag,S tag   100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Synthetic Human Un-conjugated   100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 16 Days

APLN Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
Rat (Rattus)

More Proteins for Apelin (APLN) Interaction Partners

Zebrafish Apelin (APLN) interaction partners

  1. Apelin signaling regulates lymphatic development by promoting serine-threonine kinase Akt/protein kinase B (show AKT1 Proteins) activity in a VEGF-C (show VEGFC Proteins)/VEGF receptor (show FLT1 Proteins) 3-independent manner during zebrafish embryogenesis.

  2. Apelin knockdown inhibits both hypoxia-induced endothelial cell proliferation in vitro and hypoxia-induced vessel regeneration in the caudal fin regeneration of zebrafish.

Mouse (Murine) Apelin (APLN) interaction partners

  1. miR (show MLXIP Proteins)-503 promotes cardiac fibrosis via miR (show MLXIP Proteins)-503-Apelin-13-TGF-beta (show TGFB1 Proteins)-CTGF (show CTGF Proteins)-collagen production pathway.

  2. Apelin directly interferes with thrombin-mediated signaling pathways and platelet activation, secretion, and aggregation, but not with ADP and thromboxane A2-mediated pathways.

  3. Apelin regulates inflammatory response, diminishes inflammatory remote organ damage and improves survival in an experimental model of burn sepsis, which is at least partly mediated by a phosphatidylinositol 3-kinase/protein kinase B (show AKT1 Proteins) dependent pathway.

  4. apelin is a potential activator of inflammation factors through the PI3K/Akt (show AKT1 Proteins) and Erk (show EPHB2 Proteins) signaling pathway and is potential therapeutically relevant to inflammatory responses of microglia cells

  5. we showed the effect of Apelin on RAW264.7 macrophage under normal and hypoxic condition, which could further influence the angiogenesis and inflammation process that promoted by macrophages.

  6. PDL- and Cer-induced CP resulted in increased production of the pancreatic BMP2, apelin, and PTHrP signaling systems and that significant cross talk occurred among pancreatic BMP2, apelin, and PTHrP

  7. Therapeutic potential of apelin to prevent myocardial metabolic abnormalities in heart failure paired with obesity.

  8. Data suggest that CTRP3 (cartducin) up-regulates expression and secretion of adipokines (adiponectin, leptin, visfatin, and apelin) in adipocytes; these responses to CTRP3 are down-regulated by insulin resistance or inhibition of AMPK signaling.

  9. apelin is produced by arterial endothelial cells (ECs) during embryogenesis, induces chemotaxis of venous ECs, and promotes the production of secreted Frizzled-related protein 1 (show SFRP1 Proteins) by apelin receptor (show APLNR Proteins)(+) ECs

  10. Findings demonstrate a stimulatory role for the islet cell apelin-APJ (show APLNR Proteins) signaling axis in regulation of pancreatic islet homeostasis and in metabolic induced beta-cell hyperplasia.

Cow (Bovine) Apelin (APLN) interaction partners

  1. APJ receptor (show APLNR Proteins) in granulosa cells and both apelin and the APJ receptor (show APLNR Proteins) in theca tissues are expressed in bovine ovary.

  2. The data suggest that apelin/APJ (show APLNR Proteins) system is involved in the mechanism regulating angiogenesis during follicle maturation as well as during corpora lutea formation and function in the bovine ovary.

Human Apelin (APLN) interaction partners

  1. Lower apelin and higher visfatin (show NAMPT Proteins) plasma levels in high normal blood pressure subjects compared to normal or optimal BP individuals could partially explain the higher cardiovascular risk of the high normal BP group.

  2. apelin 13 levels are elevated in patients with PE. These results suggest that apelin may be a novel biomarker and a potential therapeutic target in patients with acute PE in the future.

  3. Up-regulation of apelin and APJ (show APLNR Proteins) expression plays an important role in cardioprotection from myocardial ischemia/reperfusion injury.

  4. There was no significant change in plasma apelin levels in acute pulmonary embolism.

  5. The concentrations of gastric peptide(Ghrelin (show GHRL Proteins) and obestatin)and adipocytokines(omentin (show ITLN1 Proteins) and Apelin ) across all subgroups were lower than in the control group. The differences were statistically significant (p < 0.0001), which may be of importance in the development of the disease complications

  6. Resequencing of the apelin gene in subjects stratified by low or high apelin levels identified five APLN variants in an European population. No association was found between the most frequent variant, diabetes, and metabolic parameters.

  7. These findings suggested that Apelin/APLNR (show APLNR Proteins) signaling may be used as a potential therapeutic target for hypoxic/ischemic injury.

  8. apelin attenuates the osteoblastic differentiation of aortic valve interstitial cells via the ERK (show EPHB2 Proteins) and PI3-K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway

  9. Genetic variants in the apelin gene are significantly associated with the risk of coronary artery disease in the Turkish population.

  10. Apelin could activate multiple protective mechanisms to prevent heart, brain, liver and kidney ischemia/reperfusion injury. [Review]

Pig (Porcine) Apelin (APLN) interaction partners

  1. Pig Apelin mRNA was sequenced.

Apelin (APLN) Protein Profile

Protein Summary

This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.

Gene names and symbols associated with Apelin Proteins (APLN)

  • apelin (apln)
  • apelin (APLN)
  • apelin (apln-b)
  • apelin (Apln)
  • apelin-like (LOC100625006)
  • apelin-like (LOC100346492)
  • 6030430G11Rik protein
  • APEL protein
  • APLN protein
  • preproapelin protein
  • Xapelin protein
  • XNPEP2 protein

Protein level used designations for Apelin Proteins (APLN)

apelin , apelin, AGTRL1 ligand , preproapelin , preproapelin-b , APJ endogenous ligand , apelin; peptide ligand for APJ receptor , AGTRL1 ligand

798375 Danio rerio
611497 Canis lupus familiaris
741949 Pan troglodytes
100037057 Xenopus laevis
100038188 Xenopus (Silurana) tropicalis
30878 Mus musculus
282143 Bos taurus
8862 Homo sapiens
58812 Rattus norvegicus
101747811 Gallus gallus
100625006 Sus scrofa
100346492 Oryctolagus cuniculus
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