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APLNR encodes a member of the G protein-coupled receptor gene family. Additionally we are shipping Apelin Receptor Kits (14) and Apelin Receptor Proteins (5) and many more products for this protein.
Showing 10 out of 117 products:
Human Polyclonal Apelin Receptor Primary Antibody for IF, ELISA - ABIN1535565
ODowd, Heiber, Chan, Heng, Tsui, Kennedy, Shi, Petronis, George, Nguyen: A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. in Gene 1994
Human Polyclonal Apelin Receptor Primary Antibody for IF (p), IHC (p) - ABIN740160
Ustunel, Acar, Gemici, Ozbey, Edizer, Soylu, Tepekoy, Izgut-Uysal: The effects of water immersion and restraint stress on the expressions of apelin, apelin receptor (APJR) and apoptosis rate in the rat heart. in Acta histochemica 2014
APJ receptor in granulosa cells and both apelin (show APLN Antibodies) and the APJ receptor in theca tissues are expressed in bovine ovary.
The data suggest that apelin (show APLN Antibodies)/APJ system is involved in the mechanism regulating angiogenesis during follicle maturation as well as during corpora lutea formation and function in the bovine ovary.
Endothelial CXCR4 (show CXCR4 Antibodies) is negatively regulated by miR (show MLXIP Antibodies)-139-5p, whose transcription is in turn induced by laminar flow and APLN (show APLN Antibodies)/APLNR signalling.
apelin (show APLN Antibodies) is produced by arterial endothelial cells (ECs) during embryogenesis, induces chemotaxis of venous ECs, and promotes the production of secreted Frizzled-related protein 1 (show SFRP1 Antibodies) by apelin receptor(+) ECs
Findings demonstrate a stimulatory role for the islet cell apelin (show APLN Antibodies)-APJ signaling axis in regulation of pancreatic islet homeostasis and in metabolic induced beta-cell hyperplasia.
ERG (show ERG Antibodies) and APLNR are essential for endothelial homeostasis in venules in the lung and that perturbation in ERG (show ERG Antibodies)-APLNR signaling is crucial for the development of pulmonary veno-occlusive disease.
These findings suggest that apelin (show APLN Antibodies)-APJ signaling is a potential therapeutic target in the treatment of vasculogenic erectile dysfunction.
regulates the Nodal/Bone Morphogenetic Protein antagonist Cerberus (show CER1 Antibodies) and the Baf60c/Smarcd3 (show SMARCD3 Antibodies) subunit of the Brg1 (show SMARCA4 Antibodies)/Brm (show SMARCA2 Antibodies)-associated factors (BAF (show BANF1 Antibodies)) chromatin-remodelling complex
In obese and insulin (show INS Antibodies)-resistant mice, plasma apelin (show APLN Antibodies) concentration after fasting was not modified but, the gene-expression level of the APL (show FASL Antibodies)/APJ system was augmented in the white adipose tissue and reduced in the brown adipose tissue, liver and in kidneys.
These findings imply that the pancreatic apelin (show APLN Antibodies)-APJ system functions to curb the inflammatory and fibrosis responses during pancreatitis, and that apelin (show APLN Antibodies) reduces inflammation and fibrosis by reducing neutrophil recruitment and PSC activity.
More than half of the expected Apj-/- embryos died in utero because of cardiovascular developmental defects. Apelin (show APLN Antibodies)-APJ signaling plays a novel role as a potent regulator of endothelial MEF2 (show MEF2C Antibodies) function in the developing cardiovascular system.
Apelin (show APLN Antibodies)-APJ signalling may promote Fas (show FAS Antibodies)-induced liver injury at least partially via JNK (show MAPK8 Antibodies) activation.
The expressions of apelin (show APLN Antibodies) and APJ are significantly augmented by hypoxia through the hypoxia-inducible factor-1 alpha (HIF-1alpha (show HIF1A Antibodies)) signaling pathway.
obese (especially diabese) youngsters demonstrated lower serum apelin (show APLN Antibodies) levels; the G212A polymorphism of the APLNR gene was found to exert a favourable effect on circulating apelin (show APLN Antibodies) levels in childhood obesity
Apelin (show APLN Antibodies)-APJ system is a novel neurohormonal pathway, with studies to date suggesting that it may be of pathophysiologic relevance in Heart failure.
There was a significant correlation between APJ expression in myocardium resected after 10 min with both oxygen extraction ratio and mixed venous oxygen saturation in children undergoing surgical repair.
built 3 homology 3-D models of the ApelinR and revealed the conservation at the bottom of the apelin (show APLN Antibodies) binding site of a hydrophobic cavity in which the C-terminal Phe of pE13F was embedded
AGTRL1 genetic polymorphisms might contribute to the development of hypertension independently and/or through complex interaction.
serine 348 on the apelin receptor is a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling
APJ and B1R (show BDKRB1 Antibodies) can form heterodimers in transfected HEK293 cells and activations of APJ and B1R (show BDKRB1 Antibodies) could up-regulate eNOS (show NOS3 Antibodies) phosphorylation
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
angiotensin II receptor-like 1
, G-protein coupled receptor APJ
, angiotensin receptor-like 1
, angiotensin receptor-related protein
, apelin receptor
, APJ (apelin) receptor
, APJ receptor
, G protein-coupled receptor APJ
, G-protein coupled receptor HG11
, HG11 orphan receptor