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APLNR encodes a member of the G protein-coupled receptor gene family. Additionally we are shipping Apelin Receptor Antibodies (166) and Apelin Receptor Kits (16) and many more products for this protein.
Showing 5 out of 5 products:
APJ receptor in granulosa cells and both apelin (show APLN Proteins) and the APJ receptor in theca tissues are expressed in bovine ovary.
The data suggest that apelin (show APLN Proteins)/APJ system is involved in the mechanism regulating angiogenesis during follicle maturation as well as during corpora lutea formation and function in the bovine ovary.
the ELABELA (ELA)-APJ signaling axis is only required for sinus venosus-derived progenitors.
These results demonstrate a new pharmacologic property of protamine-blockade of APJ-that could explain some adverse effects observed in protamine-treated patients, and that the established antiangiogenic activity of protamine would rely on APJ antagonism.
Apelin (show APLN Proteins)-36-[L28C(30kDa (show TAF10 Proteins)-PEG (show PAEP Proteins))] provides a starting point for the development of diabetes therapeutics that are devoid of the blood pressure effects associated with canonical APJ activation
Results show that obese mice had significantly lower mRNA and protein expressions of apelin (show APLN Proteins)/ APJ in skeletal muscles than the normal body weight mice.
These results demonstrate that overexpression of APJ in cardiomyocytes has adverse effects on cardiac function in male and non-pregnant mice and that lactation contributes to the development of postpartum cardiomyopathy in the heart with APJ overexpression.
Endothelial CXCR4 (show CXCR4 Proteins) is negatively regulated by miR (show MLXIP Proteins)-139-5p, whose transcription is in turn induced by laminar flow and APLN (show APLN Proteins)/APLNR signalling.
apelin (show APLN Proteins) is produced by arterial endothelial cells (ECs) during embryogenesis, induces chemotaxis of venous ECs, and promotes the production of secreted Frizzled-related protein 1 (show SFRP1 Proteins) by apelin receptor(+) ECs
Findings demonstrate a stimulatory role for the islet cell apelin (show APLN Proteins)-APJ signaling axis in regulation of pancreatic islet homeostasis and in metabolic induced beta-cell hyperplasia.
ERG (show ERG Proteins) and APLNR are essential for endothelial homeostasis in venules in the lung and that perturbation in ERG (show ERG Proteins)-APLNR signaling is crucial for the development of pulmonary veno-occlusive disease.
These findings suggest that apelin (show APLN Proteins)-APJ signaling is a potential therapeutic target in the treatment of vasculogenic erectile dysfunction.
The apelin (show APLN Proteins)/APLNR axis regulates cholangiocarcinoma cell proliferation and tumor angiogenesis.
Data suggest that the differential expression of Apelin (show APLN Proteins) and Apelin receptor APJ yields a "self-generated" gradient mechanisms that accelerates the extension of the sprout.
The aim of this study was to evaluate if polymorphisms of APLN (show APLN Proteins) and APLNR genes may play a role as susceptibility markers for hypertension in a group of Mexican-Mestizo patients.
review of the important role of the Apelin (show APLN Proteins)/APJ system in pathological angiogenesis
The optimal gene-gene interaction model for both males and females with regard to hypertension was apelin (show APLN Proteins) rs3761581-apelin (show APLN Proteins) rs3115757-APJ rs7119375. In conclusion, gene polymorphisms of the apelin (show APLN Proteins)-APJ system are associated with susceptibility to hypertension.
Up-regulation of apelin (show APLN Proteins) and APJ expression plays an important role in cardioprotection from myocardial ischemia/reperfusion injury.
These findings suggested that Apelin (show APLN Proteins)/APLNR signaling may be used as a potential therapeutic target for hypoxic/ischemic injury.
The expressions of apelin (show APLN Proteins) and APJ are significantly augmented by hypoxia through the hypoxia-inducible factor-1 alpha (HIF-1alpha (show HIF1A Proteins)) signaling pathway.
obese (especially diabese) youngsters demonstrated lower serum apelin (show APLN Proteins) levels; the G212A polymorphism of the APLNR gene was found to exert a favourable effect on circulating apelin (show APLN Proteins) levels in childhood obesity
This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the pressure action of angiotensin II by exerting hypertensive effect. It functions in the cardiovascular and central nervous systems, in glucose metabolism, in embryonic and tumor angiogenesis and as a human immunodeficiency virus (HIV-1) coreceptor. Two transcript variants resulting from alternative splicing have been identified.
angiotensin II receptor-like 1
, G-protein coupled receptor APJ
, angiotensin receptor-like 1
, angiotensin receptor-related protein
, apelin receptor
, APJ (apelin) receptor
, APJ receptor
, G protein-coupled receptor APJ
, G-protein coupled receptor HG11
, HG11 orphan receptor