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Probable C to U editing enzyme whose physiological substrate is not yet known. Additionally we are shipping APOBEC2 Antibodies (85) and many more products for this protein.
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APOBEC2, a member of the cytidine deaminase (show CDA Proteins) family of DNA/RNA editing enzymes, is induced by TGFbeta (show TGFB1 Proteins) signaling, and that its activity is necessary to specify the left-right axis in Xenopus and zebrafish embryos.
Hepatocellular carcinoma developed in 2 of 20 APOBEC2 transgenic mice at 72 weeks of age.
Data show that APOBEC2 is preferentially associated with slow-twitch muscle, with its abundance being considerably greater in soleus compared with gastrocnemius muscle and, within soleus muscle, in slow as opposed to fast muscle fibers.
both APOBEC2 (despite being an ancestral member of the family with no obvious redundancy in muscle) and APOBEC3 (despite its proposed role in restricting endogenous retrotransposition) are inessential for mouse development, survival, or fertility
Findings indicate that aberrant APOBEC2 expression causes nucleotide alterations in the transcripts of the specific target gene and could be involved in the development of human hepatocellular carcinoma through hepatic inflammation.
Studies indicate the APOBEC family consists of 11 members: APOBEC-1 (Apo1), APOBEC-2 (Apo2), activation induced cytidine deaminase (AID), APOBEC- 3A, -3B, -3C, -3DE, -3F, -3H (Apo3A-H) and APOBEC- 4 (Apo4).
The APOBEC2 was confirmed to be elevated in the tonsils with IgAN patients, and the gene expression level was negatively related with serum IgG level in overall patients.
crystal structure of APOBEC2
Probable C to U editing enzyme whose physiological substrate is not yet known. Does not display detectable apoB mRNA editing. Has a low intrinsic cytidine deaminase activity. May play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation (By similarity).
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
, apolipoprotein B editing complex 2
, probable C->U-editing enzyme APOBEC-2
, apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
, apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 2