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Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3A Proteins (APOBEC3A)

APOBEC3A is a member of the cytidine deaminase gene family. Additionally we are shipping APOBEC3A Antibodies (63) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
APOBEC3A 200315 P31941
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Top APOBEC3A Proteins at antibodies-online.com

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

APOBEC3A Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,

More Proteins for Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A) Interaction Partners

Human Apolipoprotein B MRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A) interaction partners

  1. Germline variant and deletion polymorphism in APOBEC3A gene are not associated with breast cancer risk.

  2. These results indicate that the mechanisms of APOBEC3 (show APOBEC3F Proteins) restriction of Koala Retro Virus by humanA3G and mouseA3 differ (deamination dependent vs. independent) and glyco-gag does not play a role in the restriction.

  3. The role of APOBEC3A in mediating this change was confirmed by A3A overexpression in Fujioka cells, which led to a significant increase in WT1 (show WT1 Proteins) c.1303G>A mRNA editing.

  4. This study demonstrates the cellular RNA editing activity of a member of the APOBEC3 (show APOBEC3F Proteins) family of innate restriction factors and expands the understanding of C>U RNA editing in mammals.

  5. Structural studies show that specific binding of single-stranded DNA is regulated by the cooperative dimerization of APOBEC3A.

  6. AFM image analyses reveal A3A binding to single-stranded DNA, and that this interaction becomes most evident ( approximately 80% complex yield) at high protein-to-DNA ratios (at least 100ratio1). A3A is predominantly monomeric when bound to single-stranded DNA.

  7. APOBEC3A-mediated mutagenesis is much more frequent than APOBEC3B (show APOBEC3B Proteins) because APOBEC3A itself is highly proficient at generating DNA breaks.

  8. data provide a mechanistic explanation of how the APOBEC3A cytidine deaminase (show CDA Proteins) protein can inhibit L1 retrotransposition

  9. Chimeric A3A mRNA resulting from DeltaA3B was more stable, resulting in higher intracellular A3A levels and greater DNA damage.

  10. Expression of APOBEC3A or 3C in 293FT cells reduced the infectivity of HPV16 pseudovirions. The reduced infectivity of virions assembled in the presence of APOBEC3A, but not 3C, was attributed to decreased copy number of the encapsidated reporter plasmid.

APOBEC3A Protein Profile

Protein Summary

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with APOBEC3A

  • apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (APOBEC3A)
  • similar to ARP10 protein (APOBEC3A)
  • A3A protein
  • APOBEC3A protein
  • APOBEC3Z1 protein
  • ARP3 protein
  • bK150C2.1 protein
  • PHRBN protein

Protein level used designations for APOBEC3A

DNA dC->dU-editing enzyme APOBEC-3A , phorbolin 1 , phorbolin-1 , probable DNA dC->dU-editing enzyme APOBEC-3A , apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A , similar to ARP10 protein

GENE ID SPECIES
200315 Homo sapiens
507162 Bos taurus
610077 Canis lupus familiaris
610245 Canis lupus familiaris
702708 Macaca mulatta
744498 Pan troglodytes
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