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APOBEC3A is a member of the cytidine deaminase gene family. Additionally we are shipping APOBEC3A Antibodies (64) and many more products for this protein.
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High APOBEC3A expression is associated with acute myelogenous leukemia.
SNPs in APOBEC3 (show APOBEC3F Proteins) alter expression of APOBEC3A/APOBEC3B (show APOBEC3B Proteins) to affect somatic APOBEC-signature mutations.
Steady-state kinetic analysis reveals that APOBEC3A (A3A) discriminates against all ox-mCs by 3700-fold, arguing that ox-mC deamination does not contribute substantially to demethylation. A3A is, by contrast, highly proficient at C/mC deamination.
a solution-state model of APOBEC3A interaction with its single-stranded DNA substrate obtained with the 'method of small changes', is reported.
exposures to relevant environmental factors might induce APOBEC3A or APOBEC3B (show APOBEC3B Proteins) expression above genotoxic levels and initiate tumorigenesis in a tissue-specific manner in the right cellular environment where ssDNA is available
Hyperthermia may induce regression of genital warts via APOBEC3A expression in patients diagnosed with genital warts.
APOBEC3A proteins were up regulated in genital warts cell cultures taken from patients diagnosed with human papillomavirus infections.
We have demonstrated that the APOBEC3A gene of primates displays sequence variation consistent with a role in host defense against a changing pathogen or set of pathogens. Our data suggest that though APOBEC3A potently restricts LINE-1 retroelements, the rapid evolution in APOBEC3A was likely not driven by LINE-1.
crystal structures of human APOBEC3A and a chimera of human APOBEC3B (show APOBEC3B Proteins) and APOBEC3A bound to ssDNA at 3.1-A and 1.7-A resolution, respectively.
By RNA sequencing, we show that specific inhibition of complex II (succinate dehydrogenase (show SDHA Proteins); SDH) by atpenin A5 in normoxic conditions mimics hypoxia and induces hypoxic transcripts as well as APOBEC3A-mediated RNA editing in human monocytes.
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.
DNA dC->dU-editing enzyme APOBEC-3A
, phorbolin 1
, probable DNA dC->dU-editing enzyme APOBEC-3A
, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
, similar to ARP10 protein