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APOL1 encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Additionally we are shipping APOL1 Kits (24) and APOL1 Proteins (5) and many more products for this protein.
Showing 10 out of 116 products:
Human Polyclonal APOL1 Primary Antibody for IHC, IHC (p) - ABIN4281231
Madhavan, OToole, Konieczkowski, Ganesan, Bruggeman, Sedor: APOL1 localization in normal kidney and nondiabetic kidney disease. in Journal of the American Society of Nephrology : JASN 2011
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Human Monoclonal APOL1 Primary Antibody for ELISA, WB - ABIN968963
Vanhollebeke, Nielsen, Watanabe, Truc, Vanhamme, Nakajima, Moestrup, Pays: Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum. in Proceedings of the National Academy of Sciences of the United States of America 2007
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Human Polyclonal APOL1 Primary Antibody for IHC (p), WB - ABIN391541
Li, Fan, Bai, Liu, Huang, Wang, Wu, Liu, Liu: Distribution and effect of apoL-I genotype on plasma lipid and apolipoprotein levels in Chinese normalipidemic and endogenous hypertriglyceridemic subjects. in Clinica chimica acta; international journal of clinical chemistry 2009
Human Polyclonal APOL1 Primary Antibody for ELISA, WB - ABIN449525
Pérez-Morga, Vanhollebeke, Paturiaux-Hanocq, Nolan, Lins, Homblé, Vanhamme, Tebabi, Pays, Poelvoorde, Jacquet, Brasseur, Pays: Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes. in Science (New York, N.Y.) 2005
Human Polyclonal APOL1 Primary Antibody for ELISA, WB - ABIN1534643
Page, Butlin, Lomthaisong, Lowry: The human apolipoprotein L gene cluster: identification, classification, and sites of distribution. in Genomics 2001
zApoL1 is essential for proper blood filtration in the zebrafish glomerulus and that zApoL1 affects the expression of nephrin (show NPHS1 Antibodies)
The proteomic profile of apoL1 is modified in HDLs (show CSF1R Antibodies) of high cardiovascular risk patients, and apoL1 plasma levels are significantly lower in serum and in HDL3 of patients that will suffer an adverse cardiac event within 3 years.
Relationships between APOL1 kidney risk variants and cardiovascular disease (CVD) susceptibility and CVD-related death remain controversial. Some studies detected an increased risk for CVD, whereas others support protection from death and subclinical CVD and cerebrovascular disease
mice with podocyte-specific expression of either APOL1 risk allele (G1 or G2), but not of the G0 allele, develop functional (albuminuria and azotemia), structural (foot-process effacement and glomerulosclerosis) and molecular (gene-expression) changes that closely resemble human kidney disease. Expression of the risk-variant APOL1 alleles interferes with endosomal trafficking and blocks autophagic flux.
APOL1 single nucleotide polymorphisms are associated with nephropathy.
We report an unadjusted incidence of 1.2 CKD cases/100 person-years (95% CI: 0.5 to 2.5) in PHIV youth carrying APOL1 high-risk genotypes, with important implications for sub-Saharan Africa
Overall, our results suggest podocyte depletion could predispose individuals with APOL1 risk genotypes to kidney disease in response to a second stressor, and add to other published evidence associating APOL1 expression with preeclampsia
This new Drosophila model uncovers a novel mechanism by which upregulated expression of APOL1-G1 could precipitate renal disease in humans.
Results suggest a pivotal role for mitochondrial dysfunction in APOL1-associated kidney disease
Among blacks, the APOL1 high-risk genotype associated only with higher risk of end-stage renal disease in a fully adjusted analysis. Black race and APOL1 high-risk status were associated with faster eGFR (show EGFR Antibodies) decline
GSTM1 (show GSTM1 Antibodies) null and APOL1 high-risk alleles deleteriously affect chronic kidney disease progression among blacks with hypertension, and subjects with both GSTM1 (show GSTM1 Antibodies) null and APOL1 high-risk genotypes had highest risk of adverse renal outcomes
This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.