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Apoptosis Inhibitor 5 Proteins (API5)

API5 encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. Additionally we are shipping Apoptosis Inhibitor 5 Antibodies (71) and Apoptosis Inhibitor 5 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
API5 8539 Q9BZZ5
API5 11800 O35841
Rat API5 API5 362170  
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Top Apoptosis Inhibitor 5 Proteins at

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days

API5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Apoptosis Inhibitor 5 (API5) Interaction Partners

Human Apoptosis Inhibitor 5 (API5) interaction partners

  1. Authors propose a proapoptotic role for NP in IAV pathogenesis, whereby it suppresses expression of antiapoptotic factor API5, thus potentiating the E2F1 (show E2F1 Proteins)-dependent apoptotic pathway and ensuring viral replication.

  2. Authors show that API5 increases the metastatic capacity of cervical cancer cells in vitro and in vivo via up-regulation of MMP-9 (show MMP9 Proteins).

  3. rs17684886 (ZNRF1 (show ZNRF1 Proteins)) and rs599019 (COLEC12 (show COLEC12 Proteins)) are associated with diabetic retinopathy and rs6427247 (SCYL1BP1 (show GORAB Proteins)) and rs899036 (API5) are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes

  4. API5 overexpression promoted cell proliferation and colony formation in CaSki cancer cells, whereas API5 knockdown inhibited the both properties in HeLa cells; API5 expression is associated with pERK1/2 in a subset of cervical cancer patients and its expression predicts poor overall survival.

  5. miR (show MLXIP Proteins)-143 and miR (show MLXIP Proteins)-145 and the predicted target proteins API5, ERK5 (show MAPK7 Proteins), K-RAS (show HRAS Proteins), and IRS-1 (show IRS1 Proteins) display regional differences in expression in the colon

  6. Negative regulation of API-5 expression by miR-1 was demonstrated to promote apoptosis of HepG2 cells.

  7. API5 acts as an immune escape gene in tumors by rendering them resistant to apoptosis triggered by tumor antigen-specific T cells.

  8. Low miR (show MLXIP Proteins)-224 and high API5 expression correlated with worse survival of glioblastoma patients.

  9. Api5, even if not physically interacting with E2F1 (show E2F1 Proteins), contributes positively to E2F1 (show E2F1 Proteins) transcriptional activity by increasing E2F1 (show E2F1 Proteins) binding to its target promoters.

  10. structure and function of API5

Apoptosis Inhibitor 5 (API5) Protein Profile

Protein Summary

This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with Apoptosis Inhibitor 5 Proteins (API5)

  • apoptosis inhibitor 5 (api5)
  • apoptosis inhibitor 5 (API5)
  • Apoptosis inhibitor 5 (api5)
  • apoptosis inhibitor 5 (LOC100228730)
  • apoptosis inhibitor 5 (Api5)
  • AAC-11 protein
  • AAC11 protein
  • AI196452 protein
  • API-5A protein
  • API5 protein
  • api5-A protein
  • api5l1 protein
  • MGC83290 protein
  • sr:nyz021 protein
  • wu:fb26c03 protein
  • zgc:66211 protein

Protein level used designations for Apoptosis Inhibitor 5 Proteins (API5)

apoptosis inhibitor 5 , Apoptosis inhibitor 5-A , Apoptosis inhibitor 5 , apoptosis inhibitor 5-like , FIF , antiapoptosis clone 11 protein , cell migration-inducing gene 8 protein , fibroblast growth factor 2-interacting factor 2 , migration-inducing protein MIG8 , API-5 , apoptosis inhibitory protein 5

321676 Danio rerio
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451131 Pan troglodytes
716346 Macaca mulatta
100010659 Monodelphis domestica
100050009 Equus caballus
100078170 Ornithorhynchus anatinus
100195317 Salmo salar
100345733 Oryctolagus cuniculus
100378651 Saccoglossus kowalevskii
100380157 Xenopus (Silurana) tropicalis
100228730 Taeniopygia guttata
8539 Homo sapiens
11800 Mus musculus
362170 Rattus norvegicus
483413 Canis lupus familiaris
100522006 Sus scrofa
538968 Bos taurus
100717249 Cavia porcellus
423168 Gallus gallus
100173613 Pongo abelii
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