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Aquaporin 2 (Collecting Duct) Proteins (AQP2)

AQP2 encodes a water channel protein located in the kidney collecting tubule. Additionally we are shipping AQP2 Antibodies (184) and AQP2 Kits (40) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AQP2 11827 P56402
AQP2 25386 P34080
AQP2 359 P41181
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Top AQP2 Proteins at

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Cow Un-conjugated   5 applications Log in to see 1 to 2 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days

AQP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Rat (Rattus)
Human , ,
, ,

More Proteins for Aquaporin 2 (Collecting Duct) (AQP2) Interaction Partners

Mouse (Murine) Aquaporin 2 (Collecting Duct) (AQP2) interaction partners

  1. analysis of phosphorylation-dependent interactions of AQP2 with 14-3-3theta; and -zeta

  2. the activation of CaSR (show CASR Proteins) in the collecting duct prevents the cyclic AMP (show TMPRSS5 Proteins)-dependent increase in AQP2-phosphorylation at S256 and water permeability, counteracting the short-term vasopressin (show AVP Proteins) response.

  3. Functional photoconvertible chimeric AQP-2 was successfully expressed in mpkCCD cells, in which forskolin induced apical trafficking and accumulation of chimeric AQP-2.

  4. Suggest ERalpha (show ESR1 Proteins) in mediates the inhibitory effect of estradiol on AQP2 expression in collecting ducts.

  5. Data suggest that the ability of prostaglandin E2 receptor EP4 (show PTGER4 Proteins) to promote aquaporin 2 (AQP2) membrane targeting and increase AQP2 abundance makes it a therapeutic target for the treatment of congenital diabetes insipidus.

  6. Odontoblast-lineage cell line have high-cell viability under xylitol-induced hypertonic stress, which may be associated with TRPV1 (show TRPV1 Proteins) and AQP2 expressions.

  7. The direct renin (show REN Proteins) inhibitor aliskiren increased water channel (show AQP4 Proteins) AQP2 expression in obstructed kidneys of UUO mice, at least partially by preventing NLRP3 (show NLRP3 Proteins) inflammasome activation in association with ureteral obstruction.

  8. role for PKA signaling in both short- and long-term regulation of AQP2, characterizing a novel mouse model of diabetes insipidus

  9. tankyrase likely to play an important role in vasopressin (show AVP Proteins)-induced AQP2 upregulation via beta-catenin (show CTNNB1 Proteins)-mediated transcription in the kidney collecting duct cells

  10. Studied the effect of the total tannins extract of rhubarb on expression od aquaporin 2 and auqaporin 3 in diarrhoea mice.

Human Aquaporin 2 (Collecting Duct) (AQP2) interaction partners

  1. AQP2 polymorphisms (rs461872, rs7305534) were correlated with gastrointestinal toxicity of platinum-based chemotherapy in lung cancer patients

  2. report a novel mutation of the AQP2 gene and highlight an important role of genetic testing for definite diagnosis

  3. The study demonstrated the abnormal expression pattern of AQP1 (show AQP1 Proteins), AQP2, AQP3 (show AQP3 Proteins), and AQP4 (show AQP4 Proteins) in the kidney tissues of patients with nephrotic syndrome, providing a basis for an improved understanding of the role of aquaporins in the pathogenesis of this disease.

  4. In most cases (90 %), inherited nephrogenic diabetes insipidus (NDI) is an X-linked disease, caused by mutations in the AVPR2 gene. * In rare occasions (10 %), it is caused by mutations in the AQP2 gene.

  5. Partial congenital nephrogenic diabetes insipidus in the Swedish family is caused by an AQP2 variation that seems to disable the encoded AQP2-R254W protein to reach the subapical vesicle population as well as impairing its phosphorylation at S256

  6. Taken together these results provide a possible molecular mechanism explaining the increased AQP2 membrane expression under RGZ treatment: in renal cells RGZ elicits Ca(2 (show CA2 Proteins)+) transients facilitating AQP2 exposure at the apical plasma membrane

  7. U-AQP2/P-AVP (show AVP Proteins) is a novel predictor of response to TLV in patients with decompensated HF. AQP-defined responders may have a better prognosis on TLV treatment

  8. In response to hypertonic saline, urinary AQP2 increased more in chronic kidney disease patients compared to controls.

  9. results further support the view that urinary calcium can modulate the vasopressin (show AVP Proteins)-dependent urine concentration through a down-regulation of AQP2 expression/trafficking

  10. AQP2 is subjected to S-glutathionylation, which is modulated by reactive oxygen species production.

Pig (Porcine) Aquaporin 2 (Collecting Duct) (AQP2) interaction partners

  1. Aquaporin 2 promotes cell migration and epithelial morphogenesis.

  2. Data provide evidence supporting the role of S256 and S269 in the maintenance of AQP2 at the cell surface.

AQP2 Protein Profile

Protein Summary

This gene encodes a water channel protein located in the kidney collecting tubule. It belongs to the MIP/aquaporin family, some members of which are clustered together on chromosome 12q13. Mutations in this gene have been linked to autosomal dominant and recessive forms of nephrogenic diabetes insipidus.

Gene names and symbols associated with AQP2

  • aquaporin 2 (Aqp2)
  • aquaporin 2 (LOC100352066)
  • aquaporin 2 (collecting duct) (Aqp2)
  • aquaporin 2 (collecting duct) (AQP2)
  • AQP-2 protein
  • AQP-CD protein
  • aquaporin-2 protein
  • cph protein
  • jpk protein
  • WCH-CD protein

Protein level used designations for AQP2

ADH water channel , AQP-2 , aquaporin-2 , aquaporin-CD , collecting duct water channel protein , water channel protein for renal collecting duct , AQP-CD , WCH-CD , water-channel aquaporin 2 , Aquaporin-2

11827 Mus musculus
100352066 Oryctolagus cuniculus
25386 Rattus norvegicus
431304 Gallus gallus
359 Homo sapiens
486552 Canis lupus familiaris
539870 Bos taurus
443024 Ovis aries
100147810 Sus scrofa
100722014 Cavia porcellus
100059758 Equus caballus
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