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ALOX5 encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. Additionally we are shipping ALOX5 Kits (57) and ALOX5 Proteins (12) and many more products for this protein.
Showing 10 out of 206 products:
Chicken Monoclonal ALOX5 Primary Antibody for IF, IP - ABIN968116
Hundley, Prasad, Beaven: Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38 mitogen-activated protein kinase. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 5 references for ABIN968116
Human Polyclonal ALOX5 Primary Antibody for WB - ABIN372586
Dwyer, Allayee, Dwyer, Fan, Wu, Mar, Lusis, Mehrabian: Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis. in The New England journal of medicine 2004
Show all 5 references for ABIN372586
Human Polyclonal ALOX5 Primary Antibody for IF (p), IHC (p) - ABIN669651
Wang, Wang, Gao, Qu: The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice. in Drug discoveries & therapeutics 2014
Show all 2 references for ABIN669651
Human Polyclonal ALOX5 Primary Antibody for IHC, ELISA - ABIN1532500
Mancini, Ortiz, Croxatto, Gallo: Retinal upregulation of inflammatory and proangiogenic markers in a model of neonatal diabetic rats fed on a high-fat-diet. in BMC ophthalmology 2013
Dog (Canine) Polyclonal ALOX5 Primary Antibody for WB - ABIN374732
Kalayci, Birben, Sackesen, Keskin, Tahan, Wechsler, Civelek, Soyer, Adalioglu, Tuncer, Israel, Lilly: ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. in Allergy 2005
Human Polyclonal ALOX5 Primary Antibody for ICC, IF - ABIN258593
Lin, Lin, Wu, Chiu, Tang, Hour, Liou, Tu, Yang, Fu: 5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts. in PLoS ONE 2014
This study identified a SNP (rs10507391) in ALOX5 gene as a novel genetic risk factor for Alzheimer's disease and body mass index.
ALOX5 gene variants do not appear to be related to clinical CHD (show CHDH Antibodies) events or subclinical atherosclerosis regardless of bioavailable enzyme substrate levels in multiethnic cohort.
our data suggest that the inhibition of both COX-2 (show COX2 Antibodies)/5-LOX may be an effective therapeutic approach for colon cancer management, particularly for those patients with high expression of COX-2 (show COX2 Antibodies)/5-LOX
we identified differences in the frequency distribution in the Tibetan population located in the ALOX5 , VKORC1 (show VKORC1 Antibodies) and PTGS2 (show PTGS2 Antibodies) genes
AF4 and AF4-MLL (show MLL Antibodies) mediate transcriptional elongation of 5-lipoxygenase mRNA by 1, 25-dihydroxyvitamin D3.
the Alox-5 gene (show GPD1 Antibodies) might play a role in the differentiation of multiple drug resistant and non-resistant erythroleukemic cell lines
These results suggest that COX-2 (show COX2 Antibodies) and 5-LO play roles in tumorigenesis and the progression of primary glioblastoma and that the co-expression pattern of COX-2 (show COX2 Antibodies)/5-LO may be used as an independent prognostic factor in this disease.
Increased PUFA Content and 5-lipoxygenase pathway expression are associated with subcutaneous adipose tissue inflammation in obese women with type 2 diabetes.
The study shows that 5-lipoxygenase (5-LO) in B cells is phosphorylated on Ser523 and demonstrates for the first time a chemical difference between 5-LO in myeloid cells and B cells.
Study identified a novel splice variant of 5-LO consisting of 139 amino acids due to premature stop. It was found to be expressed in HepG2 cells only, raising the possibility for putative role in liver cancer development.
Data suggest that miR (show MLXIP Antibodies)-674-5p (microRNA-674-5p) serves as a negative regulator in 5-LO (arachidonate 5-lipoxygenase) mediated autoimmune liver injury; miR (show MLXIP Antibodies)-674-5p represses expression of 5-LO in hepatocytes in the presence of IL-6 (interleukin-6 (show IL6 Antibodies)) or TNFa (tumor necrosis factor-alpha (show TNF Antibodies)).
Results establish a key role of 5-Lipoxygenase in the development of the tau pathology phenotype and demonstrate it to be a novel viable therapeutic target for the pharmacologic treatment of human tauopathy.
GSAP (show PION Antibodies) cleavage via caspase-3 (show CASP3 Antibodies) is regulated and depend upon the availability of 5-Lipoxygenase in Alzheimer's disease.
SHH (show SHH Antibodies)-responsive 5-lipoxygenase, 15-lipoxygenase and COX-2 (show COX2 Antibodies) modulate Dectin-1 (show CLEC7A Antibodies)-induced inflammatory cytokines.
involvement of lipoxygenase pathways in TNF-alpha (show TNF Antibodies)-induced production of cytokines and chemokines
explored the relationship between 5-LO and central and peripheral eosinophilia in an asthma model using PAS (show PASK Antibodies) or BALB/c mice and 5-LO-deficient mutants
ALOX5 deficiency prevents stress-induced memory deficits, synaptic dysfunction and tauopathy in a mouse model of Alzheimer's disease.
5-LO activation coordinates the inflammatory immune response involved in the control of visceral leishmaniasis.
5-LO(-/-) mice subjected to kidney insult presented lower macrophage infiltration and higher levels of IL-10 (show IL10 Antibodies) than wild-type mice.
Alox5 affects the osteogenic and adipogenic abilities of iPSCs in vivo and the effect of Cox2 (show COX2 Antibodies) inhibition in this system.
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, arachidonate 5-lipoxygenase
, Arachidonate 5-lipoxygenase
, arachidonic 5-lipoxygenase alpha-10 isoform
, arachidonic 5-lipoxygenase delta-10-13 isoform
, arachidonic 5-lipoxygenase delta-13 isoform
, arachidonic 5-lipoxygenase delta-p10 isoform
, arachidonic acid 5-lipoxygenase
, leukotriene A4 synthase
, 5 - Lipoxygenase