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ALOX5 encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. Additionally we are shipping ALOX5 Kits (64) and ALOX5 Proteins (12) and many more products for this protein.
Showing 10 out of 202 products:
Chicken Monoclonal ALOX5 Primary Antibody for IF, IP - ABIN968116
Hundley, Prasad, Beaven: Elevated levels of cyclooxygenase-2 in antigen-stimulated mast cells is associated with minimal activation of p38 mitogen-activated protein kinase. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 5 references for 968116
Human Polyclonal ALOX5 Primary Antibody for IF (p), IHC (p) - ABIN669651
Wang, Wang, Gao, Qu: The comparative study of acetyl-11-keto-beta-boswellic acid (AKBA) and aspirin in the prevention of intestinal adenomatous polyposis in APC(Min/+) mice. in Drug discoveries & therapeutics 2014
Show all 2 references for 669651
Human Polyclonal ALOX5 Primary Antibody for IHC, ELISA - ABIN1532500
Mancini, Ortiz, Croxatto, Gallo: Retinal upregulation of inflammatory and proangiogenic markers in a model of neonatal diabetic rats fed on a high-fat-diet. in BMC ophthalmology 2013
Human Polyclonal ALOX5 Primary Antibody for ICC, IF - ABIN258593
Lin, Lin, Wu, Chiu, Tang, Hour, Liou, Tu, Yang, Fu: 5-Lipoxygenase inhibitors attenuate TNF-α-induced inflammation in human synovial fibroblasts. in PLoS ONE 2014
Human Polyclonal ALOX5 Primary Antibody for ELISA, WB - ABIN185698
Kalayci, Birben, Sackesen, Keskin, Tahan, Wechsler, Civelek, Soyer, Adalioglu, Tuncer, Israel, Lilly: ALOX5 promoter genotype, asthma severity and LTC production by eosinophils. in Allergy 2005
The observation that the coexpression of FLAP (show ALOX5AP Antibodies) with a subset of the 5-LOX mutants restores 5-LOX-wild-type (wt)-like levels of products formed in intact cells suggests a physical protein-protein interaction, beyond colocalization, of 5-LOX and FLAP (show ALOX5AP Antibodies).
Polymorphisms in the 5-Lipoxygenase is associated with Incident Myocardial Infarction.
our results define Alox5 as a key genetic effector of JAK2V617F in driving polycythemia vera (show IGF2BP3 Antibodies)
Adipose tissue eicosapentaenoic acid and arachidonic acid and the ALOX-5 tandem repeat polymorphism did not significantly interact to affect the risk of myocardial infarction.
coexpression of the isoforms inhibited or stimulated 5-LO-WT expression in transiently and stably transfected HEK293T cells suggesting that the isoforms have other functions than canonical leukotriene biosynthesis
a novel putative protein isoform of human 5-LO that lacks exon 4, termed 5-LODelta4, was identified.
Oxidative stress decreased the levels of PNPLA2 (show PNPLA2 Antibodies) transcripts with no effect on ALOX5 expression. Exogenous additions of P1 peptide or overexpression of the PNPLA2 (show PNPLA2 Antibodies) gene decreased both LTB4 (show PTGR1 Antibodies) levels and death of RPE (show RPE Antibodies) cells undergoing oxidative stress.
Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (show YWHAZ Antibodies), lipoxygenase and cyclooxygenase.
Copy number variation in ALOX5 is associated with NSAIDs-induced urticaria and/or angioedema.
This study identified a SNP (rs10507391) in ALOX5 gene as a novel genetic risk factor for Alzheimer's disease and body mass index.
This study demonstrates that LTB4 (show PTGR1 Antibodies) promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 (show LTB4R2 Antibodies) can fulfill this role in the absence of BL
Homocysteine directly influences 5LO expression levels and establish a previously unknown cross talk between these two pathways.
Data suggest that miR (show MLXIP Antibodies)-674-5p (microRNA-674-5p) serves as a negative regulator in 5-LO (arachidonate 5-lipoxygenase) mediated autoimmune liver injury; miR (show MLXIP Antibodies)-674-5p represses expression of 5-LO in hepatocytes in the presence of IL-6 (interleukin-6 (show IL6 Antibodies)) or TNFa (tumor necrosis factor-alpha (show TNF Antibodies)).
Results establish a key role of 5-Lipoxygenase in the development of the tau pathology phenotype and demonstrate it to be a novel viable therapeutic target for the pharmacologic treatment of human tauopathy.
GSAP (show PION Antibodies) cleavage via caspase-3 (show CASP3 Antibodies) is regulated and depend upon the availability of 5-Lipoxygenase in Alzheimer's disease.
SHH (show SHH Antibodies)-responsive 5-lipoxygenase, 15-lipoxygenase and COX-2 (show COX2 Antibodies) modulate Dectin-1 (show CLEC7A Antibodies)-induced inflammatory cytokines.
involvement of lipoxygenase pathways in TNF-alpha (show TNF Antibodies)-induced production of cytokines and chemokines
explored the relationship between 5-LO and central and peripheral eosinophilia in an asthma model using PAS (show PASK Antibodies) or BALB/c mice and 5-LO-deficient mutants
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, arachidonate 5-lipoxygenase
, Arachidonate 5-lipoxygenase
, arachidonic 5-lipoxygenase alpha-10 isoform
, arachidonic 5-lipoxygenase delta-10-13 isoform
, arachidonic 5-lipoxygenase delta-13 isoform
, arachidonic 5-lipoxygenase delta-p10 isoform
, arachidonic acid 5-lipoxygenase
, leukotriene A4 synthase
, 5 - Lipoxygenase