Arachidonate 5-Lipoxygenase Proteins (ALOX5)

ALOX5 encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. Additionally we are shipping ALOX5 Antibodies (201) and ALOX5 Kits (64) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ALOX5 240 P09917
ALOX5 25290 P12527
ALOX5 11689 P48999
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Top ALOX5 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 15 to 18 Days
$630.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,956.33
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 15 to 18 Days
$672.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 18 Days
$640.00
Details
HOST_Baculovirus Human Un-conjugated   500 units Log in to see 6 to 8 Days
$595.36
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$866.25
Details

ALOX5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Rat (Rattus) ,

Mouse (Murine) ,

More Proteins for Arachidonate 5-Lipoxygenase (ALOX5) Interaction Partners

Human Arachidonate 5-Lipoxygenase (ALOX5) interaction partners

  1. ROS (show ROS1 Proteins) production induced by the 5-LO pathway mediates the anti-cancer effects of docosahexaenoyl ethanolamide and N-arachidonoyl-L-alanine on head and neck squamous cell carcinoma cells.

  2. Specific inhibitors of COX-2 and 5-LOX decreased formation of HKD2 and HKE2 (show PFDN6 Proteins) Platelets did not form HKs from exogenous 5S-hydroxyeicosatetraenoic acid, implying that COX-1 is not involved

  3. The observation that the coexpression of FLAP (show ALOX5AP Proteins) with a subset of the 5-LOX mutants restores 5-LOX-wild-type (wt)-like levels of products formed in intact cells suggests a physical protein-protein interaction, beyond colocalization, of 5-LOX and FLAP (show ALOX5AP Proteins).

  4. Polymorphisms in the 5-Lipoxygenase is associated with Incident Myocardial Infarction.

  5. our results define Alox5 as a key genetic effector of JAK2V617F in driving polycythemia vera (show IGF2BP3 Proteins)

  6. Adipose tissue eicosapentaenoic acid and arachidonic acid and the ALOX-5 tandem repeat polymorphism did not significantly interact to affect the risk of myocardial infarction.

  7. coexpression of the isoforms inhibited or stimulated 5-LO-WT expression in transiently and stably transfected HEK293T cells suggesting that the isoforms have other functions than canonical leukotriene biosynthesis

  8. a novel putative protein isoform of human 5-LO that lacks exon 4, termed 5-LODelta4, was identified.

  9. Oxidative stress decreased the levels of PNPLA2 (show PNPLA2 Proteins) transcripts with no effect on ALOX5 expression. Exogenous additions of P1 peptide or overexpression of the PNPLA2 (show PNPLA2 Proteins) gene decreased both LTB4 (show PTGR1 Proteins) levels and death of RPE (show RPE Proteins) cells undergoing oxidative stress.

  10. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (show YWHAZ Proteins), lipoxygenase and cyclooxygenase.

Mouse (Murine) Arachidonate 5-Lipoxygenase (ALOX5) interaction partners

  1. Findings demonstrate that the up-regulation of the ALOX5 gene pathway is responsible for the development of the biochemical and behavioral sequelae of high Hcy brain levels in the context of a neurodegenerative phenotype.

  2. This study demonstrates that LTB4 promotes macrophage phagocytosis of bacteria via BLT1, and that BLT2 can fulfill this role in the absence of BL

  3. our results define Alox5 as a key genetic effector of JAK2V617F in driving polycythemia vera (show IGF2BP3 Proteins)

  4. Homocysteine directly influences 5LO expression levels and establish a previously unknown cross talk between these two pathways.

  5. Dimethyl ester of bilirubin exhibits anti-inflammatory activity through inhibition of secretory phospholipase A2 (show YWHAZ Proteins), lipoxygenase and cyclooxygenase.

  6. Data suggest that miR (show MLXIP Proteins)-674-5p (microRNA-674-5p) serves as a negative regulator in 5-LO (arachidonate 5-lipoxygenase) mediated autoimmune liver injury; miR (show MLXIP Proteins)-674-5p represses expression of 5-LO in hepatocytes in the presence of IL-6 (interleukin-6 (show IL6 Proteins)) or TNFa (tumor necrosis factor-alpha (show TNF Proteins)).

  7. Results establish a key role of 5-Lipoxygenase in the development of the tau pathology phenotype and demonstrate it to be a novel viable therapeutic target for the pharmacologic treatment of human tauopathy.

  8. GSAP (show PION Proteins) cleavage via caspase-3 (show CASP3 Proteins) is regulated and depend upon the availability of 5-Lipoxygenase in Alzheimer's disease.

  9. SHH (show SHH Proteins)-responsive 5-lipoxygenase, 15-lipoxygenase and COX-2 modulate Dectin-1 (show CLEC7A Proteins)-induced inflammatory cytokines.

  10. involvement of lipoxygenase pathways in TNF-alpha (show TNF Proteins)-induced production of cytokines and chemokines

ALOX5 Protein Profile

Protein Summary

This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ALOX5

  • arachidonate 5-lipoxygenase (alox5)
  • arachidonate 5-lipoxygenase (AFUA_4G02770)
  • arachidonate 5-lipoxygenase (AOR_1_1362014)
  • Arachidonate 5-lipoxygenase (lox5)
  • arachidonate 5-lipoxygenase (ALOX5)
  • arachidonate 5-lipoxygenase (Alox5)
  • arachidonate 5-lipoxygenase (LOC100341714)
  • 5-LO protein
  • 5-LOX protein
  • 5LO protein
  • 5LPG protein
  • 5LX protein
  • AI850497 protein
  • F730011J02 protein
  • LOG5 protein
  • lox5 protein
  • LOX5A protein
  • si:dkey-194n13.2 protein

Protein level used designations for ALOX5

LOX2 , arachidonate 5-lipoxygenase , Arachidonate 5-lipoxygenase , LOX-5 , arachidonic 5-lipoxygenase alpha-10 isoform , arachidonic 5-lipoxygenase delta-10-13 isoform , arachidonic 5-lipoxygenase delta-13 isoform , arachidonic 5-lipoxygenase delta-p10 isoform , arachidonic acid 5-lipoxygenase , leukotriene A4 synthase , 5 - Lipoxygenase , 5-LO , 5-lipoxygenase

GENE ID SPECIES
567204 Danio rerio
3503886 Aspergillus fumigatus Af293
5994193 Aspergillus oryzae RIB40
100194803 Salmo salar
240 Homo sapiens
25290 Rattus norvegicus
477753 Canis lupus familiaris
11689 Mus musculus
100341714 Oryctolagus cuniculus
100718093 Cavia porcellus
100156205 Sus scrofa
404074 Bos taurus
423769 Gallus gallus
101117390 Ovis aries
101839970 Mesocricetus auratus
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