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ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 1 Proteins (ACAP1)

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface.. Additionally we are shipping ACAP1 Antibodies (57) and ACAP1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACAP1 9744 Q15027
ACAP1 216859 Q8K2H4
Rat ACAP1 ACAP1 287443  
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Top ACAP1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ACAP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 1 (ACAP1) Interaction Partners

Human ArfGAP with Coiled-Coil, Ankyrin Repeat and PH Domains 1 (ACAP1) interaction partners

  1. The serum lever of Alzheimer's disease were decrease and the expression of ACAP1 strongly correlated with the Mini-Mental State Examination scores of the AD patients

  2. ACAP1 and ARAP2 each colocalize with Arf6 (show ARF6 Proteins) but they did not colocalize with each other and have opposing effects on focal adhesions.

  3. CENTB1 was up-regulated in patients with active UC as compared to UC remission and healthy control groups suggesting that it is involved in the inflammatory process.

  4. phosphorylation of ACAP1 relieves a localized mechanism of autoinhibition in regulating cargo binding

  5. the oncogenic potential of USP6 is linked to its ability to integrate cell migration and cytokinesis by regulating Arf6 (show ARF6 Proteins)/ACAP1.

  6. ACAP1 promotes endocytic recycling by recognizing recycling sorting signals.

  7. CENTB1 selectively down-regulates NF-kappaB (show NFKB1 Proteins) activation via NODs pathways, creating a "feedback" loop and suggesting a novel role of CENTB1 in innate immune responses to bacteria and inflammatory responses

  8. Results suggest that two ARF6 (show ARF6 Proteins) downstream molecules, PIP5K (show PIKFYVE Proteins) and ACAP1, function together in endosomal tubulation and that phosphoinositide levels may regulate endosomal dynamics.

  9. Results suggest that ACAP1, a GTPase-activating protein (GAP) for ADP-ribosylation factor (show ARF1 Proteins) (ARF) 6 (show ARF6 Proteins), is part of a novel clathrin coat complex that is regulated by ARF6 (show ARF6 Proteins) for endocytic recycling in two key physiological settings.

  10. ACAP1 has robust, constitutive Arf6 (show ARF6 Proteins) GAP activity in vivo, with little activity toward Arf1 (show ARF1 Proteins).

ACAP1 Protein Profile

Protein Summary

GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface.

Gene names and symbols associated with ACAP1

  • ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 (ACAP1)
  • ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 (Acap1)
  • Centb1 protein

Protein level used designations for ACAP1

centaurin beta1 , centaurin, beta 1 , ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 , arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1-like , arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 , centaurin-beta-1 , cnt-b1 , Arf GAP with coiled coil, ANK repeat and PH domains 1

GENE ID SPECIES
455275 Pan troglodytes
721824 Macaca mulatta
100016342 Monodelphis domestica
100072970 Equus caballus
100359236 Oryctolagus cuniculus
100481518 Ailuropoda melanoleuca
100607184 Nomascus leucogenys
100623422 Sus scrofa
508582 Bos taurus
9744 Homo sapiens
216859 Mus musculus
287443 Rattus norvegicus
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