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GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).. Additionally we are shipping Centaurin beta 2 Antibodies (54) and many more products for this protein.
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Data suggest that Rab35 (show RAB35 Proteins), interacting with TBC1D10A (show TBC1D10A Proteins), functions in vascular endothelial cells as a negative regulator of histamine-evoked, Ca2 (show CA2 Proteins)+-dependent Weibel-Palade body exocytosis, most likely acting through the downstream effectors ACAP2 and Arf6 (show ARF6 Proteins). (Rab35 (show RAB35 Proteins) = rab (show HRB Proteins) GTP-binding protein 53 (show IGFBP3 Proteins); TBC1D10A (show TBC1D10A Proteins) = TBC1 domain family member 10A (show TBC1D10A Proteins); ACAP2 = centaurin beta2; Arf6 (show ARF6 Proteins) = ADP-ribosylation factor 6 (show ARF6 Proteins))
ACAP2 is a functional homolog of C. elegans CNT-1 and its inactivation or downregulation in human cells may contribute to cancer development
ACAP2 has robust, constitutive Arf6 (show ARF6 Proteins) GAP activity in vivo, with little activity toward Arf1 (show ARF1 Proteins).
Centaurin beta2/KIAA0041, is a member of the centaurin family of ADP-ribosylation factor (show ARF1 Proteins) directed GTPase (show RACGAP1 Proteins)-activating proteins. Binding of phosphoinositides to a pleckstrin (show PLEK Proteins) homology domain may regulate subcellular localisation and activity.
Rab35 (show RAB35 Proteins) regulates phagosome formation through recruitment of ACAP2 in macrophages during FcgammaR-mediated phagocytosis.
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
, centaurin, beta 2
, arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
, arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2-like
, Arf GAP with coiled coil, ANK repeat and PH domains 2