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binds inositol(1,3,4,5)tetrakisphosphate (InsP4) and phosphatidylinositol(3,4,5)trisphosphate (PtdInsP3)\;involved in inositol phosphate or inositol lipid signal transduction [RGD, Feb 2006].. Additionally we are shipping ADAP1 Antibodies (46) and ADAP1 Proteins (4) and many more products for this protein.
This review highlights the functions of the neuron-specific protein ADAP1 in neuronal differentiation and neurodegenerative diseases, with an overview of structural and biochemical properties of ADAP1. [review]
SH-SY5Y cells, stably transfected with GFP-tagged-p42 (show EPB42 ELISA Kits)(IP4), show an enhanced NRD (show PRDM1 ELISA Kits) protein expression already at an earlier time point after retinoic acid stimulation.
Tubulin (show TUBB ELISA Kits) potentiates the interaction of the metalloendopeptidase (show THOP1 ELISA Kits) nardilysin (show NRD1 ELISA Kits) with the neuronal scaffold protein (show HOMER1 ELISA Kits) p42IP4/centaurin-alpha1 (ADAP1).
Full-length KIF13B and CENTA1 form heterotetramers that can bind four phosphoinositide molecules in the vesicle and transport it along the microtubule.
The ARFGAP domain of p42IP4 is involved in the interaction and co-localization with RanBPM (show RANBP9 ELISA Kits) protein, without being the only interaction site.
the up-regulated p42 (show EPB42 ELISA Kits)(IP4) in Alzheimer's disease neurons may serve as a docking protein to recruit signaling molecules such as different subtypes of casein kinase I (show CSNK1D ELISA Kits) to the plasma membrane.
Results show that nucleolin (show NCL ELISA Kits) interacts with centaurin-alpha(1) protein, suggesting that centaurin-alpha(1) may be part of a ribonucleoprotein (show RBP31 ELISA Kits) complex.
centaurin-alpha1 negatively regulates ARF6 (show ARF6 ELISA Kits) activity by functioning as an in vivo PIP3-dependent ARF6 (show ARF6 ELISA Kits) GAP
p42IP4 receptor is expressed and distributed throughout the cell in HEK (show EPHA3 ELISA Kits) cell lines and is located on chromosome 7, position 7p22.3.
Authors propose alternative concepts of how elevated levels of p42IP4 might relate to its interaction with nucleolin (show NCL ELISA Kits) in the pathomechanisms of Alzheimer's disease.
binds inositol(1,3,4,5)tetrakisphosphate (InsP4) and phosphatidylinositol(3,4,5)trisphosphate (PtdInsP3)\;involved in inositol phosphate or inositol lipid signal transduction
centaurin, alpha 1
, ArfGAP with dual PH domains 1
, Centaurin-alpha2 protein
, arf-GAP with dual PH domain-containing protein 1-like
, arf-GAP with dual PH domain-containing protein 1
, inositol(1,3,4,5)tetrakisphosphate receptor
, putative MAPK-activating protein PM25