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ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 Proteins (AGAP2)

The protein encoded by AGAP2 belongs to the centaurin gamma-like family. Additionally we are shipping ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 Antibodies (101) and ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AGAP2 116986 Q99490
AGAP2 216439 Q3UHD9
Rat AGAP2 AGAP2 65218 Q8CGU4
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Top ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

AGAP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) Interaction Partners

Human ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) interaction partners

  1. Mutation of Fyn (show FYN Proteins) phosphorylation sites on PIKE-A, depletion of Fyn (show FYN Proteins), or pharmacological inhibition of Fyn (show FYN Proteins) blunts the association between PIKE-A and AMPK (show PRKAA1 Proteins), resulting in loss of its inhibitory effect on AMPK (show PRKAA1 Proteins).

  2. expression of PLC-gamma1 (show PLCG1 Proteins) and PIKE positively correlated with the tumor differentiation of oral squamous cell carcinoma.

  3. PIKE reduction rescued PI3K (show PIK3CA Proteins)-dependent and -independent neuronal defects in fragile X (show FMR1 Proteins) syndrome.

  4. In this review the CENTG1 gene is amplified in a variety of human cancers which lead to the enhancement of tumor invasion.

  5. AGAP2 plays a role in the signalling and recycling of beta2-adrenergic receptors.

  6. Fyn (show FYN Proteins) regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a (show STAT5A Proteins)) through enhancing its interaction with the GTPase (show RACGAP1 Proteins) phosphoinositide 3-kinase enhancer A (PIKE-A).

  7. PIKE is highly expressed in human squamous cell carcinoma and has a critical role in EGF (show EGF Proteins)-induced squamous cell carcinoma proliferation.

  8. The presence of heterogeneous missense mutations of GGAP2 in prostate cancer was associated with aggressive clinical behavior.

  9. PIKE is a critical factor in controlling synaptic AMPA (show GRIA3 Proteins) receptor insertion.

  10. Akt (show AKT1 Proteins)-phosphorylated PIKE-A inhibits UNC5B (show UNC5B Proteins)-induced apoptosis in cancer cell lines in a p53 (show TP53 Proteins)-dependent manner. [PIKE-A]

Mouse (Murine) ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) interaction partners

  1. PIKE plays pivotal roles to advance oligodendroglia development and myelinogenesis through Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) activation.

  2. Results demonstrate that the integrity of PIKE signaling is essential for protecting the neurons from excitotoxicity-stimulated damage both in vitro and in vivo.

  3. Fyn (show FYN Proteins) regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a (show STAT5A Proteins)) through enhancing its interaction with the GTPase (show RACGAP1 Proteins) phosphoinositide 3-kinase enhancer A (PIKE-A).

  4. PIKE is a critical factor in controlling synaptic AMPA (show GRIA3 Proteins) receptor insertion.

  5. data established the critical role of PIKE in regulating neuronal survival and development by substantiating the PI3K/Akt (show AKT1 Proteins) pathway.

  6. PIKE-A is required for prolactin (show PRL Proteins)-mediated STAT5a (show STAT5A Proteins) activation in mammary gland development.

  7. PIKE knockout mice show augmented lipid oxidation, which is accompanied by enhanced AMPK (show PRKAA1 Proteins) phosphorylation in muscle and adipose tissue and is implicated in obesity and diabetes development.

  8. PIKE-L acts as a downstream survival effector for netrin-1 (show NTN1 Proteins) through UNC5B (show UNC5B Proteins) in the nervous system

ArfGAP with GTPase Domain, Ankyrin Repeat and PH Domain 2 (AGAP2) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with AGAP2

  • ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (AGAP2)
  • ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (agap2)
  • ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (Agap2)
  • Centg1 protein
  • GGAP2 protein
  • mKIAA0167 protein
  • Pike protein
  • zgc:153779 protein

Protein level used designations for AGAP2

arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 , Arf GAP with GTP-binding protein-like, ANK repeat and PH domains 2 , GTP-binding and GTPase activating protein 2 , centaurin, gamma 1 , cnt-g1 , phosphatidylinositol 3-kinase enhancer , phosphatidylinositol-3-kinase enhancer , phosphoinositide 3-kinase enhancer , AGAP-2 , PIKE , centaurin-gamma-1 , nuclear GTPase PIKE

GENE ID SPECIES
504833 Bos taurus
565109 Danio rerio
116986 Homo sapiens
216439 Mus musculus
65218 Rattus norvegicus
100050853 Equus caballus
481130 Canis lupus familiaris
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