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ASAP1 encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. Additionally we are shipping ASAP1 Antibodies (84) and ASAP1 Kits (1) and many more products for this protein.
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results, specifically, the absence of associations of polymorphisms of ASAP1 with tuberculosis (TB) risk, suggest that ASAP1 may not be a susceptibility gene for TB in Western Chinese Han and Tibetan population
results support the hypothesis that ASAP1 is a positive regulator of NM2A.
Rab11-FIP3 coordinates the interactions of ASAP1 and Rab11a with Rabin8.
The activation of NF-kappaB (show NFKB1 Proteins) induced translocation of AMAP1 to cytoplasm from cell membrane and nucleus, which resulted in augmented interaction of AMAP1 and IKKbeta (show IKBKB Proteins)
High ASAP1 expression, that was reduced after Mycobacterium tuberculosis infection, and rs10956514, are associated with the level of reduction of ASAP1 expression.
ASAP1 appears to contribute to the malignant mechanism of LSCC and may represent a significant prognostic marker for laryngeal squamous cell carcinoma patients.
results indicated that elevated expression of ASAP1 plays an important role in the progression and metastasis of ovarian cancer
Data show that co-overexpression of GEP100 (show IQSEC1 Proteins) and AMAP1 (ASAP1) correlates with rapidity of the local recurrence.
found that AMAP1 had the ability to bind directly to PRKD2 (show PKD2 Proteins) and hence to make a complex with the cytoplasmic tail of the beta1 subunit
Data suggest that GEP100 (show IQSEC1 Proteins)-Arf6 (show ARF6 Proteins)-AMAP1-cortactin (show CTTN Proteins) pathway, activated by VEGFR2 (show KDR Proteins), appears to be common in angiogenesis and cancer invasion and metastasis, and provides their new therapeutic targets.
we demonstrate that Prox1 (show C16orf35 Proteins) and Asap1 behave as negative regulators of mammary stem/progenitor function. Both of these genes have also been implicated in oncogenesis.
ASAP1 is a scaffold bringing together the proteins needed for transport to the cilia including the GTP-binding protein Arf4 & the 2 G proteins of the Rab family--Rab11 & Rab8--linked by the Rab8 guanine nucleotide exchange factor Rabin8.
ASAP1 was suggested to negatively regulate lipopolysaccharide (LPS (show TLR4 Proteins))-induced proinflammatory mediators production through down-regulating LPS (show TLR4 Proteins) signaling
DEF-1 alters cell motility through the deactivation of ARF1 (show ARF1 Proteins). In contrast, the inhibition of cell spreading by DEF-1 was not dependent on GAP activity, indicating that spreading and motility are altered by DEF-1 through different pathways.
inhibited by tyrosine kinase (show TYRO3 Proteins) Pyk2 (show PTK2B Proteins), which also regulates Arf1 (show ARF1 Proteins)
Overexpression of ASAP1 inhibits cell spreading and alters paxillin (show PXN Proteins) localization to adhesions.
ASAP1 may function as a coincidence detector of simultaneous protein association through the ASAP1 SH3 domain and phosphorylation by Src (show SRC Proteins).
ASAP3 (show ASAP3 Proteins) functions nonredundantly with ASAP1 to control cell movement and may have a role in cancer cell invasion.
This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
, development and differentiation enhancing factor 1
, arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1-like
, 130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein
, 130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein
, ADP-ribosylation factor-directed GTPase-activating protein 1
, ARF GTPase-activating protein 1
, PIP2-dependent ARF1 GAP
, arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
, centaurin, beta 4
, development and differentiation-enhancing factor 1
, differentiation-enhancing factor 1
, ArfGAP with SH3 domain, ankyrin repeat and PH domain1