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ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 Proteins (ASAP2)

ASAP2 encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. Additionally we are shipping ASAP2 Antibodies (17) and ASAP2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ASAP2 8853 O43150
ASAP2 211914 Q7SIG6
Rat ASAP2 ASAP2 362719  
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Top ASAP2 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

ASAP2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2) Interaction Partners

Human ArfGAP with SH3 Domain, Ankyrin Repeat and PH Domain 2 (ASAP2) interaction partners

  1. regulates multiple cytokine and growth factor-activated signaling pathways by acting as a recruitment factor for adapter proteins

ASAP2 Protein Profile

Protein Summary

This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ASAP2

  • ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2)
  • ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (asap2)
  • ArfGAP with SH3 domain, ankyrin repeat and PH domain 1b (asap1b)
  • ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (Asap2)
  • 6530401G17Rik protein
  • AMAP2 protein
  • asap2 protein
  • CENTB3 protein
  • Ddef2 protein
  • Gm592 protein
  • Gm1523 protein
  • PAG3 protein
  • PAP protein
  • Pap-alpha protein
  • SHAG1 protein
  • si:dkey-37o8.2 protein

Protein level used designations for ASAP2

development and differentiation enhancing factor 2 , development- and differentiation-enhancing factor 2 , ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 , asap1 , PYK2 C terminus-associated protein , arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 , centaurin, beta 3 , development and differentiation-enhancing factor 2 , paxillin-associated protein with ARF GAP activity 3 , pyk2 C-terminus-associated protein

GENE ID SPECIES
768599 Gallus gallus
100072516 Equus caballus
431962 Xenopus laevis
459014 Pan troglodytes
475659 Canis lupus familiaris
565859 Danio rerio
618009 Bos taurus
699774 Macaca mulatta
100411588 Callithrix jacchus
100440164 Pongo abelii
100548947 Meleagris gallopavo
100560107 Anolis carolinensis
100604148 Nomascus leucogenys
8853 Homo sapiens
211914 Mus musculus
362719 Rattus norvegicus
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