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Arrestin, beta 1 Proteins (ARRB1)

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Additionally we are shipping beta Arrestin 1 Antibodies (118) and beta Arrestin 1 Kits (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ARRB1 109689 Q8BWG8
ARRB1 408 P49407
ARRB1 25387 P29066
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Top beta Arrestin 1 Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$721.60
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,138.67
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$3,138.67
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,162.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,162.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 5 Days
$385.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ARRB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

More Proteins for Arrestin, beta 1 (ARRB1) Interaction Partners

Mouse (Murine) Arrestin, beta 1 (ARRB1) interaction partners

  1. data suggest that beta-arr1 mediated nuclear signaling regulates the production of excretive factors derived from niche astrocytes and expansion of neural precursors in DG, thus maintaining homeostasis of adult hippocampal neurogenesis

  2. beta-arr1 (show SAG Proteins) has a critical role in modulating ERK (show EPHB2 Proteins), JNK (show MAPK8 Proteins) and p38 MAPK (show MAPK14 Proteins) pathways mediated by TNF-alpha (show TNF Proteins) in intestinal epithelial cells.

  3. COX-2-derived PGE2 inhibits IL-10 expression in brain microglia through a novel EP2- and beta-arrestin-dependent signaling pathway.

  4. A specific hyaluronan-blocking peptide (Pep-1 (show CNDP2 Proteins)) has confirmed the inflammatory role of degraded hyaluronan as a mediator of the IL-1beta (show IL1B Proteins)-induced activation of beta-arrestin-1.

  5. Data suggest that ARRB1 enhances hepatocellular carcinogenesis by inflammation-mediated Akt (show AKT1 Proteins) signaling.

  6. Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways.

  7. Data show that knockout or knockdown of beta-arrestin-2 (show ARRB2 Proteins) (betaarr-2), but not of beta-arrestin-1 (betaarr-1), augments beta adrenoceptor (betaAR)-stimulated cyclic AMP (show TMPRSS5 Proteins) (cAMP) production.

  8. a neuroprotective role for ARRB1, in the context of cerebral ischemia, centered on the regulation of BECN1 (show BECN1 Proteins)-dependent autophagosome formation

  9. results indicate that beta-arrestin1 plays a critical role in the assembly and activation of two major canonical inflammasomes

  10. our results reveal a novel and previously unrecognized negative regulatory role of the nonhematopoietic betaArr1 in sepsis-induced inflammation

Human Arrestin, beta 1 (ARRB1) interaction partners

  1. beta-arrestins regulate oxidative stress in a Nox4 (show NOX4 Proteins)-dependent manner and increase fibrosis in heart failure.

  2. These results indicated that b-arr1 regulated ER stress/PUMA-induced mucosal epithelial apoptosis through suppression of the TNF-a/p65/iNOS signaling pathway activation and that b-arr1 is a potential therapeutic target for Portal hypertensive gastropathy.

  3. The nuclear accumulation of beta-arrestin 1 following TLR2 activation promote H4 acetylation at specific target gene promoters and may thus affect transcription of target genes in BM CD34 (show CD34 Proteins)+ cells.

  4. The identified receptor-phospho-selective mechanism for arrestin (show SAG Proteins) conformation and the spacing of the multiple phosphate-binding sites in the arrestin (show SAG Proteins) enable arrestin (show SAG Proteins) to recognize plethora phosphorylation states of numerous GPCRs.

  5. Data suggest that ARRB1 enhances hepatocellular carcinogenesis by inflammation-mediated Akt (show AKT1 Proteins) signaling.

  6. We conclude that beta-arrestin1 had a high expression in lung adenocarcinoma and beta-arrestin1 may be a promising biomarker to identify individuals with poor prognosis for patients with lung adenocarcinoma.

  7. Bradykinin stimulates pro-contractile signalling mechanisms in human myometrial cells and arrestin (show SAG Proteins) proteins play key roles in their regulation.

  8. After eight and 12 weeks of treatment with mirtazapine, scores on the 21-item Hamilton Depression Rating Scale (HAMD21) were significantly lower in patients with MDD with ARRB1 haplotype 1 than in those without haplotype 1

  9. analysis of how NK1 receptor Gs versus Gq proteins and beta-arrestin signaling is determined by interactions in the water hydrogen bond network

  10. Multivariate analysis using the Cox (show COX8A Proteins) regression model confirmed that co-expression of nuclear beta-arrestin1 and p65 (show GORASP1 Proteins) was an independent prognostic factor for tumor progression (p = 0.008

Zebrafish Arrestin, beta 1 (ARRB1) interaction partners

  1. Using in vivo time-lapse imaging and three-dimensional morphology analysis of microglia in intact zebrafish larvae, study found that beta-arrestin1, a multifunctional protein involved in various signal transductions, cell-autonomously regulated the microglial morphology.

  2. Study demonstrated that beta-arrestin1 is critically involved in zebrafish primitive hematopoiesis, where beta-arrestin1 binds to and sequesters the PcG recruiter YY1 (show YY1 Proteins), thus relieving PcG-mediated repression of cdx4-hox (show MSH2 Proteins) pathway.

Cow (Bovine) Arrestin, beta 1 (ARRB1) interaction partners

  1. The identified receptor-phospho-selective mechanism for arrestin (show SAG Proteins) conformation and the spacing of the multiple phosphate-binding sites in the arrestin (show SAG Proteins) enable arrestin (show SAG Proteins) to recognize plethora phosphorylation states of numerous GPCRs.

  2. The presented functional map quantitatively connects critical interactions in the polar core and along the C tail of arrestin (show SAG Proteins).

  3. Reduced binding of arrestin-1 to the phospho-opsin form of G90D mutant likely contributes to night blindness caused by this mutation.

  4. 3.0 A crystal structure of the bovine arrestin-1 splice variant p44, in which the activation step is mimicked by C-tail truncation

  5. Conformational dynamics of helix 8 in the GPCR rhodopsin controls arrestin (show SAG Proteins) activation in the desensitization process

  6. similar to transducin activation, rhodopsin phosphorylation by GRK1 and high affinity arrestin-1 binding only requires a rhodopsin monomer

beta Arrestin 1 (ARRB1) Protein Profile

Protein Summary

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described.

Gene names and symbols associated with Arrestin, beta 1 Proteins (ARRB1)

  • arrestin, beta 1 (ARRB1)
  • arrestin, beta 1 (arrb1)
  • beta-arrestin 1 (CpipJ_CPIJ016988)
  • beta-arrestin 1 (CpipJ_CPIJ017114)
  • beta-arrestin 1 (Smp_122900)
  • beta-arrestin 1 (Smp_126080)
  • beta-arrestin 1 (Smp_176980)
  • beta-arrestin 1 (Smp_152290)
  • arrestin, beta 1 (Arrb1)
  • 1200006I17Rik protein
  • ARB1 protein
  • ARR1 protein
  • arrb1 protein
  • AW208571 protein
  • barr1 protein
  • BARRES protein
  • betaarr1 protein
  • G430100A01Rik protein
  • MGC83787 protein

Protein level used designations for Arrestin, beta 1 Proteins (ARRB1)

arrestin, beta 1 , arrestin 1 , beta-arrestin 1 , arrestin beta 1 , beta-arrestin-1-like , arrestin beta-1 , beta-arrestin-1 , beta-arrestin1 , arrestin 2 , arrestin-2

GENE ID SPECIES
100064657 Equus caballus
446401 Xenopus laevis
447732 Xenopus laevis
451424 Pan troglodytes
695250 Macaca mulatta
6050741 Culex quinquefasciatus
6051219 Culex quinquefasciatus
8343815 Schistosoma mansoni
8346946 Schistosoma mansoni
8351664 Schistosoma mansoni
8355068 Schistosoma mansoni
100470249 Ailuropoda melanoleuca
100598721 Nomascus leucogenys
109689 Mus musculus
408 Homo sapiens
25387 Rattus norvegicus
553266 Danio rerio
281637 Bos taurus
485189 Canis lupus familiaris
100521141 Sus scrofa
100731801 Cavia porcellus
100009235 Oryctolagus cuniculus
101108418 Ovis aries
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