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Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Additionally we are shipping Arrestin 3 Antibodies (85) and Arrestin 3 Kits (27) and many more products for this protein.
Showing 7 out of 8 products:
Human Arrestin 3 Protein expressed in Wheat germ - ABIN1345726
Quack, Woznowski, Potthoff, Palmer, Königshausen, Sivritas, Schiffer, Stegbauer, Vonend, Rump, Sellin: PKC alpha mediates beta-arrestin2-dependent nephrin endocytosis in hyperglycemia. in The Journal of biological chemistry 2011
Substance P (show TAC1 Proteins) enhances tissue factor (show F3 Proteins) release from granulocyte-macrophage colony-stimulating factor (show CSF2 Proteins)-dependent macrophages via the p22phox (show CYBA Proteins)/beta-arrestin 2/Rho A (show RHOA Proteins) signaling pathway.
beta-arrestins regulate oxidative stress in a Nox4 (show NOX4 Proteins)-dependent manner and increase fibrosis in heart failure.
Results demonstrate that betaArr2 signaling may be an important pathway for TAAR1 function and that the activation of the TAAR1-D2R complex negatively modulates GSK3b signaling
Role for engagement of BARR2 by the transactivated EGFR in agonist-specific regulation of delta receptor activation of ERK1/2
Data suggest that thrombin (show F2 Proteins) can directly activate PAR2 (show F2RL1 Proteins) vasorelaxation, signal transduction (stimulating both calcium and MAP kinase (show MAPK1 Proteins) responses), and triggering beta-arrestin recruitment (both beta-arrestin 1 (show ARRB1 Proteins) and 2).
a beta-arrestin signalling cycle that is catalytically activated by the GPCR and energetically coupled to the endocytic machinery
The rare variants in ARRB2 were significantly associated with smoking status.
analysis of the crystal structure of the rhodopsin-arrestin (show SAG Proteins) complex
In this study, we aimed to exploit an in vitro model system of BPH in order to better understand the mechanisms of alpha-AR signaling in prostatic hyperplasia.
interaction of beta-arrestin with GPCRs, and the beta-arrestin conformational changes in real time and in living human cells, using a series of fluorescence resonance energy transfer (FRET)-based beta-arrestin2 biosensors
The fraction of arrestin2 molecules found in clusters larger than 100nm correlates with the magnitude of ligand-induced CCR5 internalization.
K2A mutations in arrestin-1 (show SAG Proteins), -2, and -3 significantly reduced their binding to active phosphorhodopsin.
Results reveal that multiple intramolecular interactions coordinately regulate arrestin2 interaction with clathrin, highlighting this interaction as a critical step in regulating receptor trafficking.
Beta-arrestin-2 with beta-arrestin-1 shared common mechanisms to suppress podocyte autophagy by negative regulation of ATG12-ATG5 conjugation.
[beta]-arrestin2 regulates intestinal mucosal inflammation under both homeostatic and colitic conditions. Its mode of action involves negative regulation of T-cell activation and its requirement for induction of regulatory T cells.
Results suggest that the antipruritic effects of kappa opioid receptor (show OPRK1 Proteins) agonists may not require betaarrestin2
that pro- and anti-inflammatory activities of beta-arrestin2 are determined by beta-arrestin2 ubiquitination and that changes in USP20 (show USP20 Proteins) expression and/or activity can therefore regulate inflammatory responses
This shows that mood stabilizers lamotrigine, lithium and valproate can exert behavioral effects in mice by disrupting the beta-arrestin 2-mediated regulation of Akt/GSK3 signaling by D2 dopamine receptors.
findings show for the first time that Ang II (show AGT Proteins) receptor signaling to beta-arrestin regulates ARF6 (show ARF6 Proteins) activation. These proteins together control receptor endocytosis and ultimately cell migration.
These results reveal that the protective effect of deficiency of Arrb2 is due to loss of negative regulation of Akt (show AKT1 Proteins).
that Insulin-like growth factor-1 (show IGF1 Proteins) contributes to the mucosal repair by beta-arrestin2-mediated extracellular signal-regulated kinase signaling in experimental colitis
ARRB2 is not involved in hepatocellular carcinogenesis.
morphine activated JNK2 through an arrestin-independent Src- and PKC-dependent mechanism, whereas fentanyl activated JNK2 through a Src-GRK3/arrestin-2-dependent and PKC-independent mechanism.
Arrb2 physically interacts with the beta subunit (show POLG Proteins) of trimeric G-proteins and Dishevelled (show DVL2 Proteins), the interaction between arrb2 and Dishevelled (show DVL2 Proteins) is promoted by the beta/gamma subunits of trimeric G-proteins.
results suggest that a functional interaction between beta-arrestin 2 and Smoothened may be critical to regulate hedgehog (show SHH Proteins) signaling in zebrafish development
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
arrestin beta 2
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, beta-Arrestin 2
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, arrestin 3
, beta arr2
, beta-arrestin 2