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ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial) Proteins (ASNA1)

ASNA1 represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. Additionally we are shipping ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial) Antibodies (68) and ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial) Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ASNA1 439 O43681
ASNA1 56495 O54984
ASNA1 288919  
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Top ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial) Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$2,924.17
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,927.83
Details
Yeast Caenorhabditis elegans His tag   1 mg Log in to see 56 to 66 Days
$2,927.83
Details
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
$2,927.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,942.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
Details

ASNA1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial) Proteins

  1. Human ASNA1 Protein expressed in Escherichia coli (E. coli) - ABIN1098415 : Stefanovic, Hegde: Identification of a targeting factor for posttranslational membrane protein insertion into the ER. in Cell 2007 (PubMed)
    Show all 2 references for ABIN1098415

More Proteins for ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial) (ASNA1) Interaction Partners

Human ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial) (ASNA1) interaction partners

  1. Emerin (show EMD Proteins) interacts with TRC40 in situ.

  2. The repertoire of VAPB (show VAPB Proteins) interactors is more diverse than previously anticipated and link VAPB (show VAPB Proteins) to the function of ATPase complexes such as p97 (show EIF4G2 Proteins)/FAF1 (show FAF1 Proteins) and ASNA1/transmembrane-domain recognition complex.

  3. Proteins bind to TRC40 and can utilise this component for their delivery to the ER membrane.

  4. PEX19 (show PEX19 Proteins) formed a complex with the peroxisomal tail anchored protein PEX26 (show PEX26 Proteins) in the cytosol and translocated it directly to peroxisomes by a TRC40-independent class I pathway.

  5. Results indicate calcium-modulating cyclophilin ligand (CAML (show CAMLG Proteins)) and WRB (show WRB Proteins) as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells.

  6. Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2 (show CA2 Proteins)+ sensor calneurons requires the TRC40/Asna1 protein chaperone.

  7. The coiled-coil domain of WRB (show WRB Proteins) is the binding site for TRC40/Asna1.

  8. Asna1 is required for efficient histocompatibility (HLA) class I (show MICA Proteins) downregulation mediated by viral protein BNLF2a.

  9. Asna1 can mediate membrane insertion of RAMP4 and Sec61beta without the participation of other cytosolic proteins by a mechanism that depends on the presence of ATP or ADP and a protease-sensitive receptor in the endoplasmic reticulum membrane.

  10. Human ASNA1 is highly expressed in pancreatic beta cells, but not in other pancreatic endocrine cell types, and regulates insulin secretion in cultured cells.

Mouse (Murine) ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial) (ASNA1) interaction partners

  1. Asna1 ensures retrograde transport and ER and insulin (show INS Proteins) homeostasis in beta-cells. Asna1 KO mice develop hypoinsulinemia, impaired insulin (show INS Proteins) secretion, and glucose intolerance that rapidly progresses to overt diabetes.

  2. These findings indicate that Asna1 plays a crucial role during early embryonic development.

Caenorhabditis elegans (C. elegans) ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial) (ASNA1) interaction partners

  1. Data show that the parental gene, asna-1, was not targeted by miR (show MYLIP Proteins)-249, presumably because asna-1 is involved in insulin (show INS Proteins) secretion; the cleavage of the asna-1 mRNA might be so detrimental and could be under selective pressure to escape miR (show MYLIP Proteins)-249 targeting.

  2. findings show that worms lacking activity of the asna-1 gene arrest growth reversibly at the L1 stage even when food is abundant; proposed that ASNA1 is an evolutionarily conserved modulator of insulin (show INS Proteins) signaling

  3. As(III)- & Sb(III)-stimulated ArsA ATPase activities are not restricted to bacteria. asna-1 gene from C. elegans encodes functional ArsA ATPase whose activity is stimulated by As(III) & Sb(III), which is critical for As(III) & Sb(III) tolerance.

ArsA Arsenite Transporter, ATP-Binding, Homolog 1 (Bacterial) (ASNA1) Protein Profile

Protein Summary

This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion.

Gene names and symbols associated with ASNA1

  • arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) (ASNA1)
  • L-asparaginase (asnA1)
  • arsenical pump-driving ATPase (ATEG_04670)
  • arsenical pump-driving ATPase (arsA2)
  • arsenical pump-driving ATPase (arsA)
  • arsenical pump-driving ATPase (HCAG_00048)
  • arsenical pump-driving atpase (AaeL_AAEL011136)
  • arsenical pump-driving atpase (AaeL_AAEL012316)
  • arsenical pump-driving ATPase (CC1G_08655)
  • arsenical pump-driving ATPase (CpipJ_CPIJ005690)
  • arsenical pump-driving ATPase (PTRG_02265)
  • arsenical pump-driving ATPase (pKlebpneu12_p77)
  • arsenical pump-driving ATPase (UREG_07455)
  • arsenical pump-driving ATPase (BDBG_06308)
  • arsenical pump-driving ATPase (MCYG_00630)
  • arsenical pump-driving ATPase (MGYG_01332)
  • arsenical pump-driving ATPase (Tsp_06776)
  • arsenical pump-driving ATPase (LOC100284977)
  • arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) (asna1)
  • arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) (Asna1)
  • Protein ASNA-1 (asna-1)
  • 1810048H22Rik protein
  • ArsA protein
  • arsa-i protein
  • arsa1 protein
  • ASNA-I protein
  • asna1 protein
  • GET3 protein
  • hASNA-I protein
  • MGC146316 protein
  • TRC40 protein
  • wu:fd05d03 protein
  • zgc:56540 protein
  • zgc:86799 protein

Protein level used designations for ASNA1

arsA arsenite transporter, ATP-binding, homolog 1 (bacterial) , L-asparaginase , ATPase ASNA1-like , arsenical pump-driving ATPase , arsenical pump-driving atpase , arsA arsenite transporter, ATP-binding homolog 1 , arsenical resistance ATPase , arsenite-transporting ATPase , arsenite-translocating ATPase , ATPase ASNA1 , arsenite-stimulated ATPase , golgi to ER traffic 3 homolog , transmembrane domain recognition complex 40 kDa ATPase subunit , transmembrane domain recognition complex, 40kDa , ATPase Asna1 , arsA arsenite transporter, ATP-binding, homolog 1 , Arsenical pump-driving ATPase , Arsenical resistance ATPase , Arsenite-translocating ATPase , Arsenite-transporting ATPase , ATPase asna1

GENE ID SPECIES
455750 Pan troglodytes
476699 Canis lupus familiaris
6405192 Lactobacillus casei BL23
100009968 Monodelphis domestica
100063417 Equus caballus
100397739 Callithrix jacchus
100446918 Pongo abelii
4320480 Aspergillus terreus NIH2624
4713862 Yersinia enterocolitica subsp. enterocolitica 8081
4997018 Aeromonas salmonicida subsp. salmonicida A449
5451122 Ajellomyces capsulatus NAm1
5574421 Aedes aegypti
5576083 Aedes aegypti
6004933 Coprinopsis cinerea okayama7130
6037313 Culex quinquefasciatus
6339772 Pyrenophora tritici-repentis Pt-1C-BFP
6994023 Klebsiella pneumoniae
8444273 Uncinocarpus reesii 1704
8509224 Ajellomyces dermatitidis SLH14081
9225832 Arthroderma otae CBS 113480
10032576 Arthroderma gypseum CBS 118893
10911886 Trichinella spiralis
100284977 Zea mays
779794 Xenopus (Silurana) tropicalis
439 Homo sapiens
56495 Mus musculus
288919 Rattus norvegicus
504586 Bos taurus
325704 Danio rerio
444297 Xenopus laevis
176254 Caenorhabditis elegans
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