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AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008].. Additionally we are shipping AS3MT Antibodies (21) and AS3MT Kits (14) and many more products for this protein.
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Human AS3MT Protein expressed in Escherichia coli (E. coli) - ABIN1098286
Sumi, Fukushima, Miyataka, Himeno: Alternative splicing variants of human arsenic (+3 oxidation state) methyltransferase. in Biochemical and biophysical research communications 2011
Show all 2 references for ABIN1098286
genome-wide association study in population in United States (AZ, OK, SD, ND): Data suggest SNPs in AS3MT (rs17878846, rs10509760) partly explain inter-individual variability in susceptibility to arsenic poisoning (and urine arsenic species patterns).
The present study found that rs3740400 in As3MT and rs156697 in GSTO2 were strongly associated with the arsenic species (%iAs, %MMA and MMA/iAs and DMA/MMA ratios) in urine of the occupationally exposed workers and they may influence methylation capacity.
analysis of the functional roles of GSH and the crucial Cys (show DNAJC5 Proteins) residues in iAs3+ methylation catalyzed by hAS3MT
a strong signal of positive selection in the main arsenic methyltransferase AS3MT gene, which has been previously associated with lower concentrations of the most toxic product of arsenic metabolism monomethylarsonic acid.
This study's results provide preliminary evidence for the over-transmission of the A allele at the AS3MT rs11191454 polymorphism in Attention Deficit Hyperactivity Disorder.
Genetic variation in AS3MT gene is associated with arsenic metabolism and risk of basal cell carcinoma.
Two SNPs, AS3MT 12390 (rs3740393) and 14458 (rs11191439) were consistently related to arsenic methylation regardless of the populations examined for the analysis.
AS3MT SNPs were associated with arsenic metabolism efficiency and arsenic toxicity in exposed individuals.
Low-level arsenic exposure is associated with cognitive functioning; however, this association is modified by an AS3MT gene.
A hypomethylated region in the AS3MT promoter was associated with higher arsenic exposure.Arsenic exposure influences the epigenetic regulation of AS3MT.
Data, including date from studies in knockout mice, suggest that As3mt is involved in energy metabolism in a sex-specific manner, independent of inorganic arsenic poisoning; thus, As3mt may be involved in cellular processes beyond methylation of inorganic arsenic.
Oxidative damage and Ogg1 (show OGG1 Proteins) deficient background exacerbate repair deficiencies.. Overexpression of the arsenic metabolizing enzyme As3mt acts as adaptive mechanism.
Simple hyperplasia of the bladder epithelium was detected in all As3mt KO mice treated with sodium arsenite.
Rat, mouse and human are efficient methylators of inorganic arsenic. Findings suggest a role for AS3MT in the methylation of inorganic arsenic.
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002
arsenic (+3 oxidation state) methyltransferase
, arsenite methyltransferase
, arsenite methyltransferase-like
, S-adenosyl-L-methionine:arsenic(III) methyltransferase
, S-adenosylmethionine:arsenic (III) methyltransferase
, methylarsonite methyltransferase
, methyltransferase cyt19
, methyltransferase Cyt19