Arsenic (+3 Oxidation State) Methyltransferase Proteins (AS3MT)

AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008].. Additionally we are shipping AS3MT Antibodies (23) and AS3MT Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
AS3MT 57412 Q9HBK9
AS3MT 57344 Q91WU5
AS3MT 140925 Q8VHT6
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Top AS3MT Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
$319.00
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,010.33
Details
HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 11 to 12 Days
$313.60
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$382.86
Details

AS3MT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Arsenic (+3 Oxidation State) Methyltransferase (AS3MT) Interaction Partners

Human Arsenic (+3 Oxidation State) Methyltransferase (AS3MT) interaction partners

  1. this study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 (show NT5C2 Proteins) in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus

  2. AS3MT and N6AMT1 (show N6AMT1 Proteins) polymorphisms and urinary arsenic metabolites (%iAs, %MMA (show MMD Proteins), %DMA (show HLA-DMA Proteins)) in 722 subjects from an arsenic-cancer case-control study in a uniquely exposed area in northern Chile, were examined.

  3. Risk alleles spanning multiple genes across the 10q24.32 schizophrenia-related locus are associated in the human brain selectively with an increase in the expression of both BLOC-1 (show BLOC1S1 Proteins) related complex subunit 7 (show CCT7 Proteins) (BORCS7) and a previously uncharacterized, human-specific arsenite methyltransferase (AS3MT) isoform (AS3MTd2d3).

  4. A joint dose-response effect was identified for a AS3MT high-risk haplotype and inefficient arsenic methylation capacity on developmental delay.

  5. genome-wide association study in population in United States (AZ, OK, SD, ND): Data suggest SNPs in AS3MT (rs17878846, rs10509760) partly explain inter-individual variability in susceptibility to arsenic poisoning (and urine arsenic species patterns).

  6. The present study found that rs3740400 in As3MT and rs156697 in GSTO2 were strongly associated with the arsenic species (%iAs, %MMA and MMA/iAs and DMA/MMA ratios) in urine of the occupationally exposed workers and they may influence methylation capacity.

  7. analysis of the functional roles of GSH and the crucial Cys (show DNAJC5 Proteins) residues in iAs3+ methylation catalyzed by hAS3MT

  8. a strong signal of positive selection in the main arsenic methyltransferase AS3MT gene, which has been previously associated with lower concentrations of the most toxic product of arsenic metabolism monomethylarsonic acid.

  9. This study's results provide preliminary evidence for the over-transmission of the A allele at the AS3MT rs11191454 polymorphism in Attention Deficit Hyperactivity Disorder.

  10. Genetic variation in AS3MT gene is associated with arsenic metabolism and risk of basal cell carcinoma.

Mouse (Murine) Arsenic (+3 Oxidation State) Methyltransferase (AS3MT) interaction partners

  1. Data, including date from studies in knockout mice, suggest that As3mt is involved in energy metabolism in a sex-specific manner, independent of inorganic arsenic poisoning; thus, As3mt may be involved in cellular processes beyond methylation of inorganic arsenic.

  2. Oxidative damage and Ogg1 (show OGG1 Proteins) deficient background exacerbate repair deficiencies.. Overexpression of the arsenic metabolizing enzyme As3mt acts as adaptive mechanism.

  3. Simple hyperplasia of the bladder epithelium was detected in all As3mt KO mice treated with sodium arsenite.

  4. Rat, mouse and human are efficient methylators of inorganic arsenic. Findings suggest a role for AS3MT in the methylation of inorganic arsenic.

AS3MT Protein Profile

Protein Summary

AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002

Gene names and symbols associated with AS3MT

  • arsenic (+3 oxidation state) methyltransferase (AS3MT)
  • arsenic (+3 oxidation state) methyltransferase (as3mt)
  • arsenic (+3 oxidation state) methyltransferase (ABO_2182)
  • arsenic (+3 oxidation state) methyltransferase (As3mt)
  • 2310045H08Rik protein
  • AS3MT protein
  • Cyt19 protein
  • DKFZp469A1918 protein
  • zgc:136933 protein

Protein level used designations for AS3MT

arsenic (+3 oxidation state) methyltransferase , arsenite methyltransferase , arsenite methyltransferase-like , S-adenosyl-L-methionine:arsenic(III) methyltransferase , S-adenosylmethionine:arsenic (III) methyltransferase , methylarsonite methyltransferase , methyltransferase cyt19 , methyltransferase Cyt19

GENE ID SPECIES
423870 Gallus gallus
450703 Pan troglodytes
486865 Canis lupus familiaris
505482 Bos taurus
664699 Danio rerio
714122 Macaca mulatta
788389 Bos taurus
100157047 Sus scrofa
100173119 Pongo abelii
100216291 Xenopus (Silurana) tropicalis
100286452 Salmo salar
100341970 Oryctolagus cuniculus
100477280 Ailuropoda melanoleuca
4212516 Alcanivorax borkumensis SK2
100528174 Ictalurus punctatus
57412 Homo sapiens
57344 Mus musculus
140925 Rattus norvegicus
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