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AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002 [PubMed 11790780]).[supplied by OMIM, Mar 2008].. Additionally we are shipping AS3MT Antibodies (23) and AS3MT Kits (15) and many more products for this protein.
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The combined analysis confirmed evidence of genome-wide significant associations in the Han Chinese population for three loci, at 2p16.1 (rs1051061, in an exon of VRK2, P=1.14 x 10-12, odds ratio (OR)=1.17), 6p22.1 (rs115070292 in an intron of GABBR1, P=4.96 x 10-10, OR=0.77) and 10q24.32 (rs10883795 in an intron of AS3MT, P=7.94 x 10-10, OR=0.87; rs10883765 at an intron of ARL3, P=3.06 x 10-9, OR=0.87).
this study implicates altered neural expression of BORCS7, AS3MT, and NT5C2 (show NT5C2 Proteins) in susceptibility to schizophrenia arising from genetic variation at the chromosome 10q24 locus
AS3MT and N6AMT1 (show N6AMT1 Proteins) polymorphisms and urinary arsenic metabolites (%iAs, %MMA (show MMD Proteins), %DMA (show HLA-DMA Proteins)) in 722 subjects from an arsenic-cancer case-control study in a uniquely exposed area in northern Chile, were examined.
Risk alleles spanning multiple genes across the 10q24.32 schizophrenia-related locus are associated in the human brain selectively with an increase in the expression of both BLOC-1 (show BLOC1S1 Proteins) related complex subunit 7 (show CCT7 Proteins) (BORCS7) and a previously uncharacterized, human-specific arsenite methyltransferase (AS3MT) isoform (AS3MTd2d3).
A joint dose-response effect was identified for a AS3MT high-risk haplotype and inefficient arsenic methylation capacity on developmental delay.
genome-wide association study in population in United States (AZ, OK, SD, ND): Data suggest SNPs in AS3MT (rs17878846, rs10509760) partly explain inter-individual variability in susceptibility to arsenic poisoning (and urine arsenic species patterns).
The present study found that rs3740400 in As3MT and rs156697 in GSTO2 were strongly associated with the arsenic species (%iAs, %MMA and MMA/iAs and DMA/MMA ratios) in urine of the occupationally exposed workers and they may influence methylation capacity.
analysis of the functional roles of GSH and the crucial Cys (show DNAJC5 Proteins) residues in iAs3+ methylation catalyzed by hAS3MT
a strong signal of positive selection in the main arsenic methyltransferase AS3MT gene, which has been previously associated with lower concentrations of the most toxic product of arsenic metabolism monomethylarsonic acid.
This study's results provide preliminary evidence for the over-transmission of the A allele at the AS3MT rs11191454 polymorphism in Attention Deficit Hyperactivity Disorder.
Data, including date from studies in knockout mice, suggest that As3mt is involved in energy metabolism in a sex-specific manner, independent of inorganic arsenic poisoning; thus, As3mt may be involved in cellular processes beyond methylation of inorganic arsenic.
Oxidative damage and Ogg1 (show OGG1 Proteins) deficient background exacerbate repair deficiencies.. Overexpression of the arsenic metabolizing enzyme As3mt acts as adaptive mechanism.
Simple hyperplasia of the bladder epithelium was detected in all As3mt KO mice treated with sodium arsenite.
Rat, mouse and human are efficient methylators of inorganic arsenic. Findings suggest a role for AS3MT in the methylation of inorganic arsenic.
AS3MT catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to trivalent arsenical and may play a role in arsenic metabolism (Lin et al., 2002
arsenic (+3 oxidation state) methyltransferase
, arsenite methyltransferase
, arsenite methyltransferase-like
, S-adenosyl-L-methionine:arsenic(III) methyltransferase
, S-adenosylmethionine:arsenic (III) methyltransferase
, methylarsonite methyltransferase
, methyltransferase cyt19
, methyltransferase Cyt19