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Artemin Proteins (ARTN)

The protein encoded by ARTN is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. Additionally we are shipping ARTN Antibodies (86) and ARTN Kits (29) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ARTN 9048 Q5T4W7
ARTN 11876 Q9Z0L2
ARTN 362572 Q6AYE8
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Top ARTN Proteins at antibodies-online.com

Showing 10 out of 27 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 4 to 6 Days
$412.50
Details
HOST_Human Cells Mouse Fc Tag 100 μg Log in to see 16 Days
$492.80
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   1 mg Log in to see 2 to 3 Days
$4,173.75
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 7 to 9 Days
$328.21
Details
Yeast REACT_Brine Shrimp His tag   1 mg Log in to see 56 to 66 Days
$2,575.83
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$616.00
Details
HOST_Escherichia coli (E. coli) Rat His tag,HIS-T7 100 μg Log in to see 11 to 13 Days
$668.80
Details

ARTN Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
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Mouse (Murine) ,
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Rat (Rattus) ,
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More Proteins for Artemin (ARTN) Interaction Partners

Human Artemin (ARTN) interaction partners

  1. mRNA expression of Artemin (Artn) in the tongue mucosa of patients with burning mouth syndrome was significantly higher than that of control subjects.

  2. This is the first report of increased levels of a neurotrophic factor (show NTF3 Proteins) and of a glial cell line-derived neurotrophic factor (show GDNF Proteins) family member in GAD (show GAD1 Proteins) patients.

  3. conclude that ARTN is one mediator of acquired resistance to trastuzumab in HER2 (show ERBB2 Proteins)-positive mammary carcinoma cells

  4. The expression of GFRalpha1 (show GFRA1 Proteins) and/or GFRalpha3 (show GFRA3 Proteins), especially when combined with ARTN expression, may be useful predictors of disease progression and outcome in specific subtypes of mammary carcinoma.

  5. ARTEMIN promotes de novo angiogenesis in ER negative mammary carcinoma through activation of TWIST1 (show TWIST1 Proteins)-VEGF-A (show VEGFA Proteins) signaling.

  6. ARTN promotion of the cancer stem cell-like cell phenotype was mediated by TWIST1 (show TWIST1 Proteins) regulation of BCL-2 (show BCL2 Proteins) expression.

  7. High artemin promotes motility and invasiveness of pancreatic cancer.

  8. artemin lowers the threshold of temperature-dependent itch sensation.

  9. ARTN and TWIST1 (show TWIST1 Proteins) synergize to produce a worse outcome in ER-MC and combined inhibition of ARTN and phosphatidylinositol 3-kinase/protein kinase B (show AKT1 Proteins) (PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins)) may therefore provide a novel therapeutic strategy in this subtype of mammary carcinoma.

  10. Presenting an efficient method for the recombinant bacterial production of large quantities of highly pure, biologically active ARTN for in vitro and in vivo studies.

Mouse (Murine) Artemin (ARTN) interaction partners

  1. RET (show RET Proteins) coupling to ERK (show EPHB2 Proteins) and Akt (show AKT1 Proteins) depends strongly on artemin concentration, and it is highest at the low (~100 pM) artemin levels required for neurite outgrowth.

  2. We found that artemin, the specific GFRalpha3 (show GFRA3 Proteins) ligand that evokes heat hyperalgesia, robustly sensitized cold responses in a TRPM8 (show TRPM8 Proteins)-dependent manner in mice.

  3. artemin lowers the threshold of temperature-dependent itch sensation.

  4. a role for the glial-derived neurotrophic factor ARTN in mood disorders is suggested.

  5. Increase in levels of artemin and GFRalpha3 (show GFRA3 Proteins) regulates C-fiber recruitment after axotomy and regeneration.

  6. Artemin-deficient mice revealed abnormalities in the migration and axonal projection pattern of the sympathetic nervous system. Artemin guides sympathetic fibers in following blood vessels as they project toward their final targets.

  7. The level of artemin in the skin modulates gene expression and response properties of afferents that project to the skin and these changes lead to behavioral sensitivity to both hot and cold stimuli.

  8. These results suggest a potential role for artemin-responsive sensory afferents in mediating sensitivity associated with tissue injury

  9. Data report an autocrine/paracrine role of the artemin-GFRA3 (show GFRA3 Proteins) signaling system in regulating early embryonic development and apoptosis.

ARTN Protein Profile

Protein Summary

The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Artemin Proteins (ARTN)

  • artemin (ARTN)
  • artemin (Artn)
  • artemin-like (LOC100624603)
  • ARTN protein
  • ENOVIN protein
  • EVN protein
  • NBN protein
  • neublastin protein

Protein level used designations for Artemin Proteins (ARTN)

artemin , neurotrophic factor artemin , neublastin , neurotrophic factor

GENE ID SPECIES
469310 Pan troglodytes
701641 Macaca mulatta
9048 Homo sapiens
11876 Mus musculus
362572 Rattus norvegicus
100719457 Cavia porcellus
530812 Bos taurus
100857910 Gallus gallus
100624603 Sus scrofa
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