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AHR encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. Additionally we are shipping Aryl Hydrocarbon Receptor Antibodies (249) and Aryl Hydrocarbon Receptor Kits (46) and many more products for this protein.
Showing 8 out of 9 products:
Human Aryl Hydrocarbon Receptor Protein expressed in Wheat germ - ABIN1344642
van den Bogaard, Bergboer, Vonk-Bergers, van Vlijmen-Willems, Hato, van der Valk, Schröder, Joosten, Zeeuwen, Schalkwijk: Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis. in The Journal of clinical investigation 2013
Show all 2 references for ABIN1344642
Identified structural features of AHR1beta associated with low TCDD sensitivity. Substitution of the entire ligand binding domain with the corresponding sequence from mouse AHR(b-1) dramatically increased TCDD responsiveness in transactivation assays.
Transient AHR activation and cytochrome P450 1A (CYP1A) induction in livers occurred during ANIT-induced hepatobiliary impairment in medaka.
Oxidative stress induced (show SQSTM1 Proteins) by particulate matter, could up-regulates the expression of phase I and phase II metabolize enzymes. This up-regulation occurs by the activation of transcription factors (such as nuclear factor (erythroid-derived 2) -like 2 (show NFE2L2 Proteins)-related factor (Nrf2 (show GABPA Proteins)) and aryl hydrocarbon receptor (AhR)). [Review]
Data suggest that activation of the AhR/ARNT (show ARNT Proteins) (aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator (show ARNT Proteins)) signaling by AhR ligands (environmental carcinogens TCDD/3MC/PCB used here) represents novel mechanism for regulating the expression of ADH1B (alcohol dehydrogenase 1B (show ADH1B Proteins)) and other isoenzymes (ADH4 (show ADH4 Proteins), ADH6 (show ADH6 Proteins)) in hepatocytes.
AhR affects the transforming growth factor-beta signaling pathway by inducing Smad4 (show SMAD4 Proteins) degradation by the proteasome and suppressing tumor metastasis via epithelial to mesenchymal transition reduction in lung cancer cells.
Resveratrol and all its derivatives reduced also SULT1E1 (show SULT1E1 Proteins) mRNA transcript level. The reduced expression of AhR, CYP1A1 (show CYP1A1 Proteins), and 1B1 was also found as a result of treatment with these compounds.
results imply involvement of Ah receptor in regulation of CYP19A1 (show CYP19A1 Proteins), the gene-encoding aromatase (show CYP19A1 Proteins), and an enzyme responsible for a key step in the biosynthesis of estrogens.
Data show that aromatic hydrocarbon receptor (AHR) activation inhibits vascular endothelial growth factor (VEGF)-induced vasculogenesis of endothelial progenitor cells (EPCs) by hypoxia in PC-3 and LNCaP cells.
Ahr ligand aminoflavone targets breast cancer cells with stem cell-like properties, at least in part by abolishing alpha6-integrin expression.
Benzo[ghi]perylene activates the AhR pathway to exert its toxic effects on the NL-20 human bronchial cell line .
Mixed-ligand copper(II) complexes activate AhR and induce AhR-dependent CYP (show PPIG Proteins)!a1/2 genes in human hepatocytes.
the AhR inhibits lipid synthesis and involves in cell differentiation of human SZ95 sebocytes.
steroid hormones, AhR and estrogen receptor beta (show ESR2 Proteins) are affected by TCDD and genistein in granulosa cells of medium porcine follicles
AHR mRNA expression in follicular, theca, and granulosa cells suggest the involvement of AHR in the modulation of reproductive processes in the porcine ovary.
Disruption of the Ahr gene alters macrophage polarization when compared to WT macrophage
At a functional level, the loss of AhR in antigen presenting cells resulted in a dysfunctional epithelial barrier, associated with a more aggressive chemically induced colitis compared to wild type animals.
Activation of aryl hydrocarbon receptor ameliorated dextran sulfate sodium-induced acute colitis.
Results suggest that AhR activity plays a role in regulating granule neuron number and differentiation, possibly by coordinating this granule neuron precursor cell developmental transition
AhR plays an important role in myocardial ischaemic injury and inflammation promotion, and baicalin attenuates myocardial necrosis and remodeling though suppression of the inflammatory response by inhibiting AhR activation.
effects resulted from the activation of AhR as shown by RNA interference, chromatin immunoprecipitation and the use of several AhR ligands
Developmental AHR activation by pollutants, and other exogenous ligands, increases the likelihood that Gnaq knockout mice will develop autoimmune diseases later in life.
AhR and NF-kappaB/Rel protein binding profile within the 3'IghRR mediates the inhibitory effects of TCDD on Ig expression and therefore antibody levels.
AhR is a negative regulator of profibrotic signals in the gut (show GUSB Proteins).
This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.
aryl hydrocarbon receptor
, aryl hydrocarbon receptor 1
, aryl hydrocarbon receptor-like
, ah receptor
, aromatic hydrocarbon receptor
, class E basic helix-loop-helix protein 76
, Ah receptor
, dioxin receptor