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Ash1 (Absent, Small, Or Homeotic)-like Proteins (ASH1L)

ASH1L encodes a member of the trithorax group of transcriptional activators. Additionally we are shipping ASH1L Antibodies (36) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat ASH1L ASH1L 310638  
ASH1L 55870 Q9NR48
Mouse ASH1L ASH1L 192195 Q99MY8
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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag,DYKDDDDK Tag Recombinant ASH1L (2407-2579) protein gel. ASH1L (2407-2579) protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. 100 μg Log in to see 1 to 2 Days
$460.83
Details

ASH1L Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Ash1 (Absent, Small, Or Homeotic)-like (ASH1L) Interaction Partners

Human Ash1 (Absent, Small, Or Homeotic)-like (ASH1L) interaction partners

  1. Structural features were identified in ASH1L related to its' function and enzymatic activity.

  2. Both ASH1L and SETD2 are H3K36 specific methyltransferases but only SETD2 can trimethylate this mark.

  3. These data demonstrate that miR (show MLXIP Proteins)-142-3p downregulation has a role in thyroid tumorigenesis, by regulating ASH1L and MLL1.

  4. Our results uncover a novel regulatory cascade orchestrated by Ash1l with RAR (show RARA Proteins) and provide insights into mechanisms underlying the establishment of the transcriptional activation that counteracts Polycomb (show CBX2 Proteins) silencing

  5. all of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1, and NSD2 (show WHSC1 Proteins) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 Proteins), and Pr-Set7 (show SETD8 Proteins) were not affected by ubH2A.

  6. induction of Cdk5 (show CDK5 Proteins) activity is a novel mechanism through which hASH1 (show ASCL1 Proteins) may regulate migration in lung carcinogenesis

  7. Long Non-coding RNA, DBE-T recruits the Trithorax (show MLLT1 Proteins) group protein Ash1L to the FSHD locus, driving histone H3 (show HIST3H3 Proteins) lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription.

  8. ASH1 (show ASCL1 Proteins) and MLL1 synergize in activation of Hox (show MSH2 Proteins) genes.

  9. human ASH1L specifically methylates histone H3 (show HIST3H3 Proteins) Lys (show LYZ Proteins)-36.

  10. These data suggest that ASH1L occupies most, if not all, active genes and methylates histone H3 (show HIST3H3 Proteins) in a nonredundant fashion at a subset of genes.

Mouse (Murine) Ash1 (Absent, Small, Or Homeotic)-like (ASH1L) interaction partners

  1. Histone Methyltransferase Ash1l Is a Target of miR (show MLXIP Proteins)-291 and Regulates Hox (show MSH2 Proteins) Gene Expression.

  2. Ash1l is a novel key regulator of changes associated with the adaptation of HSCs to the BM niche at the fetal to adult transition or upon transplantation of HSCs into an adult recipient.

  3. all of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1, and NSD2 (show WHSC1 Proteins) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 Proteins), and Pr-Set7 (show SETD8 Proteins) were not affected by ubH2A.

  4. Ash1l-mediated H3K4 methylation at the Tnfaip3 (show TNFAIP3 Proteins) promoter is required for controlling innate IL-6 (show IL6 Proteins) production and suppressing inflammatory autoimmune diseases, providing mechanistic insight into epigenetic modulation of immune responses and inflammation

  5. ASH1 (show ASCL1 Proteins) mono- or di-methylates histone H3 (show HIST3H3 Proteins) K36 (show KRT36 Proteins) but not any other lysine residues of recombinant unmodified mammalian histones

  6. the C-terminal part of ASH1 (show ASCL1 Proteins) interacts with HDAC1 (show HDAC1 Proteins) repression complexes, suggesting that the PHD (show PDC Proteins) finger of ASH1 (show ASCL1 Proteins) may be involved in down-regulation of genes for normal development of alphabeta T cells.

ASH1L Protein Profile

Protein Summary

This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions.

Gene names and symbols associated with ASH1L

  • ash1 (absent, small, or homeotic)-like (Drosophila) (Ash1l)
  • ash1 (absent, small, or homeotic)-like (Drosophila) (ASH1L)
  • ash1 (absent, small, or homeotic)-like (Drosophila) (ash1l)
  • absent, small, or homeotic discs 1 homolog (ash1l)
  • Ash1l protein (CpipJ_CPIJ001203)
  • 8030453L17Rik protein
  • Ash1 protein
  • ASH1L protein
  • ASH1L1 protein
  • Ci-ZF(PHD)-13 protein
  • DKFZp468L0923 protein
  • E430018P19Rik protein
  • fi34d11 protein
  • Kmt2h protein
  • si:ch211-81a5.3 protein
  • wu:fi34d11 protein

Protein level used designations for ASH1L

probable histone-lysine N-methyltransferase ASH1L , ash1 (absent, small, or homeotic)-like (Drosophila) , zinc finger (PHD)-13 , Ash1l protein , absent, small, or homeotic 1-like , ASH1-like protein , absent small and homeotic disks protein 1 homolog , histone-lysine N-methyltransferase ASH1L , lysine N-methyltransferase 2H , absent, small, or homeotic discs 1 , chromatin remodeling factor

GENE ID SPECIES
310638 Rattus norvegicus
425064 Gallus gallus
480128 Canis lupus familiaris
540563 Bos taurus
457370 Pan troglodytes
563799 Danio rerio
778906 Ciona intestinalis
6032233 Culex quinquefasciatus
100017118 Monodelphis domestica
100057386 Equus caballus
100174377 Pongo abelii
100354541 Oryctolagus cuniculus
55870 Homo sapiens
192195 Mus musculus
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