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ASH1L encodes a member of the trithorax group of transcriptional activators. Additionally we are shipping ASH1L Proteins (2) and many more products for this protein.
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Our data suggest a role for ASH1L, a methyl transferase protein and member of the trithorax (show MLLT1 Antibodies) (Trx (show VAC14 Antibodies)) family, in regulation of the HBB (show HBB Antibodies) gene and as a potential modifier of beta-thalassaemia severity.
Structural features were identified in ASH1L related to its' function and enzymatic activity.
Both ASH1L and SETD2 (show SETD2 Antibodies) are H3K36 specific methyltransferases but only SETD2 (show SETD2 Antibodies) can trimethylate this mark.
These data demonstrate that miR (show MLXIP Antibodies)-142-3p downregulation has a role in thyroid tumorigenesis, by regulating ASH1L and MLL1.
Our results uncover a novel regulatory cascade orchestrated by Ash1l with RAR (show RARA Antibodies) and provide insights into mechanisms underlying the establishment of the transcriptional activation that counteracts Polycomb (show CBX2 Antibodies) silencing
all of the H3K36-specific methyltransferases, including ASH1L, HYPB (show SETD2 Antibodies), NSD1 (show NSD1 Antibodies), and NSD2 (show WHSC1 Antibodies) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 Antibodies), and Pr-Set7 (show SETD8 Antibodies) were not affected by ubH2A.
induction of Cdk5 (show CDK5 Antibodies) activity is a novel mechanism through which hASH1 (show ASCL1 Antibodies) may regulate migration in lung carcinogenesis
Long Non-coding RNA, DBE-T recruits the Trithorax (show MLLT1 Antibodies) group protein Ash1L to the FSHD locus, driving histone H3 (show HIST3H3 Antibodies) lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription.
ASH1 (show ASCL1 Antibodies) and MLL1 synergize in activation of Hox (show MSH2 Antibodies) genes.
human ASH1L specifically methylates histone H3 (show HIST3H3 Antibodies) Lys (show LYZ Antibodies)-36.
Histone Methyltransferase Ash1l Is a Target of miR (show MLXIP Antibodies)-291 and Regulates Hox (show MSH2 Antibodies) Gene Expression.
Ash1l is a novel key regulator of changes associated with the adaptation of HSCs to the BM niche at the fetal to adult transition or upon transplantation of HSCs into an adult recipient.
Ash1l-mediated H3K4 methylation at the Tnfaip3 (show TNFAIP3 Antibodies) promoter is required for controlling innate IL-6 (show IL6 Antibodies) production and suppressing inflammatory autoimmune diseases, providing mechanistic insight into epigenetic modulation of immune responses and inflammation
ASH1 (show ASCL1 Antibodies) mono- or di-methylates histone H3 (show HIST3H3 Antibodies) K36 (show KRT36 Antibodies) but not any other lysine residues of recombinant unmodified mammalian histones
the C-terminal part of ASH1 (show ASCL1 Antibodies) interacts with HDAC1 (show HDAC1 Antibodies) repression complexes, suggesting that the PHD (show PDC Antibodies) finger of ASH1 (show ASCL1 Antibodies) may be involved in down-regulation of genes for normal development of alphabeta T cells.
This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions.
probable histone-lysine N-methyltransferase ASH1L
, ash1 (absent, small, or homeotic)-like (Drosophila)
, zinc finger (PHD)-13
, Ash1l protein
, absent, small, or homeotic 1-like
, ASH1-like protein
, absent small and homeotic disks protein 1 homolog
, histone-lysine N-methyltransferase ASH1L
, lysine N-methyltransferase 2H
, absent, small, or homeotic discs 1
, chromatin remodeling factor