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ASH1L encodes a member of the trithorax group of transcriptional activators. Additionally we are shipping ASH1L Antibodies (40) and ASH1L Proteins (2) and many more products for this protein.
Epigenetic regulators play vital roles in cancer pathogenesis and represent a new frontier in therapeutic targeting. Our studies provide basic mechanistic insight into the role of H3K36me2 in transcription activation and MLL (show MLL ELISA Kits) leukemia pathogenesis and implicate ASH1L histone methyltransferase as a promising target for novel molecular therapy.
Our data suggest a role for ASH1L, a methyl transferase protein and member of the trithorax (Trx) family, in regulation of the HBB gene and as a potential modifier of beta-thalassaemia severity.
Structural features were identified in ASH1L related to its' function and enzymatic activity.
Both ASH1L and SETD2 are H3K36 specific methyltransferases but only SETD2 can trimethylate this mark.
These data demonstrate that miR (show MLXIP ELISA Kits)-142-3p downregulation has a role in thyroid tumorigenesis, by regulating ASH1L and MLL1.
Our results uncover a novel regulatory cascade orchestrated by Ash1l with RAR (show RARA ELISA Kits) and provide insights into mechanisms underlying the establishment of the transcriptional activation that counteracts Polycomb (show CBX2 ELISA Kits) silencing
all of the H3K36-specific methyltransferases, including ASH1L, HYPB, NSD1 (show NSD1 ELISA Kits), and NSD2 (show WHSC1 ELISA Kits) were inhibited by ubH2A, whereas the other histone methyltransferases, including PRC2, G9a (show EHMT2 ELISA Kits), and Pr-Set7 (show SETD8 ELISA Kits) were not affected by ubH2A.
induction of Cdk5 (show CDK5 ELISA Kits) activity is a novel mechanism through which hASH1 (show ASCL1 ELISA Kits) may regulate migration in lung carcinogenesis
Long Non-coding RNA, DBE-T recruits the Trithorax group protein Ash1L to the FSHD locus, driving histone H3 (show HIST3H3 ELISA Kits) lysine 36 dimethylation, chromatin remodeling, and 4q35 gene transcription.
ASH1 (show ASCL1 ELISA Kits) and MLL1 synergize in activation of Hox (show MSH2 ELISA Kits) genes.
Histone Methyltransferase Ash1l Is a Target of miR (show MLXIP ELISA Kits)-291 and Regulates Hox (show MSH2 ELISA Kits) Gene Expression.
Ash1l is a novel key regulator of changes associated with the adaptation of HSCs to the BM niche at the fetal to adult transition or upon transplantation of HSCs into an adult recipient.
Ash1l-mediated H3K4 methylation at the Tnfaip3 (show TNFAIP3 ELISA Kits) promoter is required for controlling innate IL-6 (show IL6 ELISA Kits) production and suppressing inflammatory autoimmune diseases, providing mechanistic insight into epigenetic modulation of immune responses and inflammation
ASH1 (show ASCL1 ELISA Kits) mono- or di-methylates histone H3 (show HIST3H3 ELISA Kits) K36 (show KRT36 ELISA Kits) but not any other lysine residues of recombinant unmodified mammalian histones
the C-terminal part of ASH1 (show ASCL1 ELISA Kits) interacts with HDAC1 (show HDAC1 ELISA Kits) repression complexes, suggesting that the PHD (show PDC ELISA Kits) finger of ASH1 (show ASCL1 ELISA Kits) may be involved in down-regulation of genes for normal development of alphabeta T cells.
This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions.
probable histone-lysine N-methyltransferase ASH1L
, ash1 (absent, small, or homeotic)-like (Drosophila)
, zinc finger (PHD)-13
, Ash1l protein
, absent, small, or homeotic 1-like
, ASH1-like protein
, absent small and homeotic disks protein 1 homolog
, histone-lysine N-methyltransferase ASH1L
, lysine N-methyltransferase 2H
, absent, small, or homeotic discs 1
, chromatin remodeling factor