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Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. Additionally we are shipping ASH2L Proteins (6) and many more products for this protein.
Showing 10 out of 64 products:
Human Polyclonal ASH2L Primary Antibody for ChIPSeq, ChIP - ABIN2668850
Cao, Chen, Cierpicki, Liu, Basrur, Lei, Dou: An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain. in PLoS ONE 2010
Show all 2 references for ABIN2668850
Human Polyclonal ASH2L Primary Antibody for WB - ABIN871691
Wysocka, Myers, Laherty, Eisenman, Herr: Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. in Genes & development 2003
Show all 2 references for ABIN871691
Cow (Bovine) Polyclonal ASH2L Primary Antibody for WB - ABIN2778326
Yokoyama, Wang, Wysocka, Sanyal, Aufiero, Kitabayashi, Herr, Cleary: Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression. in Molecular and cellular biology 2004
Dog (Canine) Polyclonal ASH2L Primary Antibody for WB - ABIN2787566
Lüscher-Firzlaff, Gawlista, Vervoorts, Kapelle, Braunschweig, Walsemann, Rodgarkia-Schamberger, Schuchlautz, Dreschers, Kremmer, Lilischkis, Cerni, Wellmann, Lüscher: The human trithorax protein hASH2 functions as an oncoprotein. in Cancer research 2008
the histone methyltransferase core enzyme ASH2L was bound at EGFR (show EGFR Antibodies) in the germinal matrix and in gliomas where levels of H3K4me3 are high, and the histone acetyltransferase P300 (show EP300 Antibodies) was bound in samples with H3K27ac enrichment
Ash2L acts in concert with P53 promoter occupancy to activate RNA Polymerase II by aiding formation of a stable transcription pre-initiation complex required for its activation.
ASH2L enhances ERalpha (show ESR1 Antibodies) expression as a coactivator of GATA3 (show GATA3 Antibodies) in breast cancers
Non active site mutations in the MLL1 SET domain render the protein defective for H3K4 dimethylation by the MLL1 core complex, which is associated with a loss of the ability of MLL1 to interact with WRAD or with the RbBP5 (show RBBP5 Antibodies)/Ash2L heterodimer.
Data indicate that MLL1 methylates Ash2L in the absence of histone H3 (show HIST3H3 Antibodies), but only when assembled within a complex with WDR5 (show WDR5 Antibodies) and RbBP5 (show RBBP5 Antibodies).
H2B dependent regulation of MLL (show MLL Antibodies) family histone methylatransferases depends on the N-terminal WH motif of ASH2L.
crystal structure of the C-terminal SPRY domain of human Ash2L
The structure shows that Ash2L contains an atypical PHD (show PDC Antibodies) finger that does not have histone tail-binding activity.
ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain.
NF-Y acts upstream of H3K4me3 deposition by recruiting Ash2L
Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells
Tbx1 (show TBX1 Antibodies) and Ash2l have overlapping mRNA and protein expression patterns during development.
Several candidate targets of complexes containing Ap2delta and Ash2l were identified that can be used to further elucidate their roles during development and showed that Fgfr3 (show FGFR3 Antibodies) is a novel direct target of these complexes.
Ap2delta associates with ASH2L and MLL2 (ALR (show MLL2 Antibodies)), forming a complex that methylates lysine 4 of histone H3 (show HIST3H3 Antibodies).
Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis (By similarity).
, hypothetical protein
, ASH2-like protein
, set1/Ash2 histone methyltransferase complex subunit ASH2