anti-Asp (Abnormal Spindle) Homolog, Microcephaly Associated (Drosophila) (ASPM) Antibodies

ASPM is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Additionally we are shipping ASPM Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Rat ASPM ASPM 289054  
ASPM 259266 Q8IZT6
ASPM 12316 Q8CJ27
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Top anti-ASPM Antibodies at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IHC 0.1 mL Log in to see 7 to 9 Days
$538.13
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-ASPM antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN960544 concentration 5 ug/ml. 50 μg Log in to see 7 to 9 Days
$595.83
Details
Human Rabbit Un-conjugated ICC, IF ASPM / MCPH5 antibody tested by immunofluorescence. Top right: HeLa cells stained with ASPM / MCPH5 antibody (2 µg/ml). Top left: Same cells stained with alpha Tubulin mAb (Clone 5-B-1-2). Bottom left: Stained with DAPI. Bottom right: Merge of all 3 images. ASPM / MCPH5 antibody tested by immunofluorescence. Top right: HeLa cells stained with ASPM / MCPH5 antibody (2 µg/ml). Top left: Same cells stained with alpha Tubulin mAb (Clone 5-B-1-2). Bottom left: Stained with DAPI. Bottom right: Merge of all 3 images. 100 μg Log in to see 1 to 2 Days
$495.83
Details
Human Rabbit Un-conjugated ICC, IHC   100 μL Log in to see 7 to 9 Days
$991.83
Details
Human Rabbit Un-conjugated IHC, ELISA   100 μg Log in to see 11 to 16 Days
$633.29
Details
Human Rabbit Un-conjugated ICC, IF   100 μL Log in to see 7 to 9 Days
$625.17
Details
Human Rabbit Un-conjugated ICC, IF   10 μg Log in to see 1 to 2 Days
$116.67
Details

ASPM Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , ,


Mouse (Murine)


Top referenced anti-ASPM Antibodies

  1. Human Polyclonal ASPM Primary Antibody for ICC, IF - ABIN250665 : Griffith, Walker, Martin, Vagnarelli, Stiff, Vernay, Al Sanna, Saggar, Hamel, Earnshaw, Jeggo, Jackson, ODriscoll: Mutations in pericentrin cause Seckel syndrome with defective ATR-dependent DNA damage signaling. in Nature genetics 2008 (PubMed)
    Show all 3 references for 250665

More Antibodies against ASPM Interaction Partners

Human Asp (Abnormal Spindle) Homolog, Microcephaly Associated (Drosophila) (ASPM) interaction partners

  1. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.

  2. Through co-expression analysis, ASPM was identified and validated in association with the progression of Hepatitis C virus cirrhosis probably by regulating tumor-related phosphorylation.

  3. The results confirm that mutations in ASPM or WDR62 (show WDR62 Antibodies) are the major cause of autosomal recessive primary microcephaly in the Pakistani population.

  4. A novel homozygous splice-site variant in the ASPM gene was identified. The variant is predicted to have an effect on splicing. Human Splice Finder, an in silico tool, predicted skipping of exon 16 due to this variant. Skipping of exon 16 may change the order and number of IQ motifs in the ASPM protein leading to typical autosomal recessive primary microcephaly phenotype.

  5. contrary to current opinion, the cortical volume and surface area of patients with ASPM mutations is reduced depending on a regionally specific fashion and their cognitive profile reflects this heterogeneity.

  6. Suberoylanilide hydroxamic acid enhanced the expression of malignant genes such as ASPM in lung cancer cells remaining after treatment, creating a more drug-resistant state.

  7. Gene-level tests showed that DRD2 (show DRD2 Antibodies) was associated with vocabulary, ASPM with vocabulary and reading decoding, and AVPR1A (show AVPR1A Antibodies) with all three endophenotypes.

  8. ASPM mutations in primary autosomal recessive microcephaly patients in ethnically diverse patients

  9. microcephalin (show MCPH1 Antibodies) and ASPM expression are deregulated in epithelial ovarian cancer progression

  10. ASPM promotes aggressiveness of pancreatic ductal adenocarcinoma (PDAC) by maintaining Wnt (show WNT2 Antibodies)-beta-catenin (show CTNNB1 Antibodies) signaling and stem cell features of PDAC cells.

Mouse (Murine) Asp (Abnormal Spindle) Homolog, Microcephaly Associated (Drosophila) (ASPM) interaction partners

  1. in this study we have provided evidence that ASPM controls spindle orientation by regulating the dynamics of astral MT and that CITK is a critical downstream partner of ASPM for this activity.

  2. Aspm and Wdr62 (show WDR62 Antibodies) interact genetically to control brain size, with mice lacking Wdr62 (show WDR62 Antibodies), Aspm, or both showing gene dose-related centriole duplication defects that parallel the severity of the microcephaly and increased ectopic basal progenitors, suggesting premature delamination from the ventricular zone.

  3. Interaction between ASPM and the Cdk2 (show CDK2 Antibodies)/Cyclin E (show CCNE1 Antibodies) complex regulated the Cyclin (show PCNA Antibodies) activity by modulating its ubiquitination and localization into the nucleus.

  4. Aspm, a gene that is mutated in familial microcephaly, regulates postnatal neurogenesis in the cerebellum and supports the growth of medulloblastoma, the most common malignant pediatric brain tumor.

  5. Aspm is essential to the proliferation and differentiation of neural stem/progenitor cells. The Aspm gene loss model provided a novel pathogenetic insight into acquired microcephaly, which can be caused by in utero exposure teratogens.

  6. ASPM plays a critical role in meiotic spindle assembly and meiotic progression in mouse oocytes.

  7. AspM is expressed by proliferating cells of the adult mouse SVZ that can generate neuroblasts fated to become olfactory bulb neurons

  8. knockdown of Aspm results in decreased Wnt (show WNT2 Antibodies)-mediated transcription

  9. truncated Aspm proteins cause a massive loss of germ cells, resulting in a severe reduction in testis and ovary size accompanied by reduced fertility

  10. tissue distribution of Calmbp1 in fetal and adult mice

ASPM Antigen Profile

Protein Summary

This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ASPM

  • asp (abnormal spindle) homolog, microcephaly associated (Drosophila) (Aspm) antibody
  • asp (abnormal spindle) homolog, microcephaly associated (Drosophila) (ASPM) antibody
  • asp (abnormal spindle) homolog, microcephaly associated (Drosophila) (LOC100232605) antibody
  • asp (abnormal spindle) homolog, microcephaly associated (aspm) antibody
  • asp (abnormal spindle)-like, microcephaly associated (Drosophila) (Aspm) antibody
  • ASP antibody
  • ASPM antibody
  • Calmbp1 antibody
  • D330028K02Rik antibody
  • MCPH5 antibody
  • Sha1 antibody

Protein level used designations for ASPM

asp (abnormal spindle) homolog, microcephaly associated , calmodulin binding protein 1 , asp (abnormal spindle)-like, microcephaly associated , asp (abnormal spindle) homolog, microcephaly associated (Drosophila) , Abnormal spindle-like microcephaly-associated protein homolog , abnormal spindle-like microcephaly-associated protein , abnormal spindle-like microcephaly-associated protein homolog , abnormal spindle-like microcephaly protein , calmodulin-binding protein 1 , calmodulin-binding protein Sha1 , spindle and hydroxyurea checkpoint abnormal protein

GENE ID SPECIES
289054 Rattus norvegicus
424354 Gallus gallus
449566 Pan troglodytes
100232605 Taeniopygia guttata
100379990 Xenopus (Silurana) tropicalis
259266 Homo sapiens
534849 Bos taurus
493695 Felis catus
443284 Ovis aries
480009 Canis lupus familiaris
711153 Macaca mulatta
12316 Mus musculus
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